Heteromultivalency enables enhanced detection of nucleic acid mutations

Detecting genetic mutations such as single nucleotide polymorphisms (SNPs) is necessary to prescribe effective cancer therapies, perform genetic analyses and distinguish similar viral strains. Traditionally, SNP sensing uses short oligonucleotide probes that differentially bind the SNP and wild-type...

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Veröffentlicht in:	Nature chemistry 2024-02, Vol.16 (2), p.229-238
Hauptverfasser:	Deal, Brendan R., Ma, Rong, Narum, Steven, Ogasawara, Hiroaki, Duan, Yuxin, Kindt, James T., Salaita, Khalid
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1513/2192 631/1647/1888/1890 639/638/11/872 Affinity Analytical Chemistry Binding Biochemistry Cancer therapies Chemistry Chemistry and Materials Science Chemistry/Food Science Deoxyribonucleic acid DNA DNA probes Genetic analysis Hybridization Inorganic Chemistry Mutation Nucleic acids Nucleotides Oligonucleotides Organic Chemistry Physical Chemistry Severe acute respiratory syndrome coronavirus 2 Single-nucleotide polymorphism Strains (organisms) Viral diseases
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