Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation

The with-no-lysine kinase 4 (WNK4)-sterile 20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway mediates activating phosphorylation of the furosemide-sensitive Na -K -2Cl cotransporter (NKCC2) and the thiazide-sensitive NaCl cotransporter (NCC). The...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 2024-01, Vol.326 (1), p.F39-F56
Hauptverfasser:	Maeoka, Yujiro, Nguyen, Luan T, Sharma, Avika, Cornelius, Ryan J, Su, Xiao-Tong, Gutierrez, Marissa R, Carbajal-Contreras, Héctor, Castañeda-Bueno, María, Gamba, Gerardo, McCormick, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Amino acids Animal models Animals Furosemide Mice Mice, Inbred C57BL Oxidative stress Phosphorylation Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Pseudohypoaldosteronism - genetics Pseudohypoaldosteronism - metabolism Sodium chloride Solute Carrier Family 12, Member 3 - genetics Solute Carrier Family 12, Member 3 - metabolism Thiazides Ubiquitin-protein ligase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!