The Current Mismatch Between COVID-19 Clinical Trial Design and the Evolving Profile of Hospitalized Patients: A Retrospective Cohort Analysis

The Current Mismatch Between COVID-19 Clinical Trial Design and the Evolving Profile of Hospitalized Patients: A Retrospective Cohort Analysis

Abstract Evaluating 100 adult coronavirus disease 2019 (COVID-19) patients at a Madrid hospital, we identified a mismatch between current clinical trial designs and the evolving profile of hospitalized patients. Most patients were ineligible due to design constraints, suggesting a need to rethink tr...

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Veröffentlicht in:Clinical infectious diseases 2024-04, Vol.78 (4), p.918-921
Hauptverfasser: Montejano, Rocio, Soler-Carracedo, Alfredo, Borobia, Alberto M, Martin-Quiros, Alejandro, Grandioso, David, Cañada, Carlos, Roman, Alicia, Arribas, Jose R
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Sprache:eng
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Zusammenfassung:Abstract Evaluating 100 adult coronavirus disease 2019 (COVID-19) patients at a Madrid hospital, we identified a mismatch between current clinical trial designs and the evolving profile of hospitalized patients. Most patients were ineligible due to design constraints, suggesting a need to rethink trial criteria for a more accurate representation of the hospitalized COVID-19 cohort.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciad655