Molecular engineering of insulin for recombinant expression in yeast

Half of the global insulin supply for pharmaceutical application is produced using recombinant secretory expression by the yeast Saccharomyces cerevisiae.Molecular adaptation of insulin is necessary for secretory expression in S. cerevisiae.The effectiveness of insulin precursor expression by S. cer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2024-04, Vol.42 (4), p.464-478
Hauptverfasser:	Kjeldsen, Thomas, Andersen, Asser Sloth, Hubálek, František, Johansson, Eva, Kreiner, Frederik Flindt, Schluckebier, Gerd, Kurtzhals, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Amino acids Crystal structure Diabetes Diabetes mellitus Engineering Insulin insulin structural engineering molecular adaptation for expression Peptides Pharmaceuticals Protein engineering recombinant production Saccharomyces cerevisiae Structural members thermodynamic folding stability Yeast Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!