HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice

In an effort to improve HLA-"humanized" mouse models for type 1 diabetes (T1D) therapy development, we previously generated directly in the NOD strain CRISPR/Cas9-mediated deletions of various combinations of murine MHC genes. These new models improved upon previously available platforms b...

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Veröffentlicht in:	The Journal of immunology (1950) 2023-12, Vol.211 (12), p.1792-1805
Hauptverfasser:	Racine, Jeremy J, Misherghi, Adel, Dwyer, Jennifer R, Maser, Richard, Forte, Elvira, Bedard, Olivia, Sattler, Susanne, Pugliese, Alberto, Landry, Laurie, Elso, Colleen, Nakayama, Maki, Mannering, Stuart, Rosenthal, Nadia, Serreze, David V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Experimental Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - therapy HLA-DQ Antigens Humans Insulin Mice Mice, Inbred NOD Mice, Knockout Mice, Transgenic Receptors, Antigen, T-Cell - genetics
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