Association between persistent organic pollutants in human milk and the infant growth and development throughout the first year postpartum in a cohort from Rio de Janeiro, Brazil
Persistent organic pollutants (POPs) are compounds that are recalcitrant and ubiquitous that bioaccumulate in human milk (HM) and can impact infant growth and development. We explore the association between POP concentration in HM at 2–50 days postpartum and infant growth and development trajectory...
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| Veröffentlicht in: | Environmental science and pollution research international 2023-11, Vol.30 (54), p.115050-115063 |
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| description | Persistent organic pollutants (POPs) are compounds that are recalcitrant and ubiquitous that bioaccumulate in human milk (HM) and can impact infant growth and development. We explore the association between POP concentration in HM at 2–50 days postpartum and infant growth and development trajectory throughout the first year of life. A cohort of 68 healthy adult Brazilian women and their infants were followed from 28 to 35 gestational weeks to 12 months postpartum. HM samples were collected between 2 and 50 days postpartum, and POP concentrations were analyzed using gas chromatography with mass spectrometry. Concentrations of POPs >limit of quantification (LOQ) were defined as presence, and concentrations ≤LOQ as an absence. Growth
z
-scores were analyzed according to WHO growth charts and infant development scores according to Age & Stages Questionnaires at 1 (
n
= 66), 6 (
n
= 50), and 12 months (
n
= 45). Linear mixed effects (LME) models were used to investigate the association of POPs in HM with infant growth and development. Benjamini-Hochberg (BH) correction for multiple testing was performed to reduce the false discovery ratio.
P
< 0.1 was considered for models with the interaction between POPs and time/sex. After BH correction, adjusted LME models with time interaction showed (1) a positive association between the presence of β hexachlorocyclohexane and an increase in head circumference-for-age
z
-score (
β
= 0.003,
P
= 0.095); (2) negative associations between total POPs (
β
= −0.000002,
P
= 0.10), total organochlorine pesticides (
β
= −0.000002,
P
= 0.10), and dichlorodiphenyldichloroethylene concentrations in HM (
β
= −0.000002,
P
= 0.10) and fine motor scores. No statistical difference between the sexes was observed. Postnatal exposure to organochlorine pesticides in HM shows a positive association with the trajectory of head circumference-for-age
z
-score and a negative association with the trajectories of fine motor skills scores. Future studies on POP variation in HM at different postpartum times and their effect on infant growth and development should be encouraged. |
| doi_str_mv | 10.1007/s11356-023-30316-y |
| format | Article |
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z
-scores were analyzed according to WHO growth charts and infant development scores according to Age & Stages Questionnaires at 1 (
n
= 66), 6 (
n
= 50), and 12 months (
n
= 45). Linear mixed effects (LME) models were used to investigate the association of POPs in HM with infant growth and development. Benjamini-Hochberg (BH) correction for multiple testing was performed to reduce the false discovery ratio.
P
< 0.1 was considered for models with the interaction between POPs and time/sex. After BH correction, adjusted LME models with time interaction showed (1) a positive association between the presence of β hexachlorocyclohexane and an increase in head circumference-for-age
z
-score (
β
= 0.003,
P
= 0.095); (2) negative associations between total POPs (
β
= −0.000002,
P
= 0.10), total organochlorine pesticides (
β
= −0.000002,
P
= 0.10), and dichlorodiphenyldichloroethylene concentrations in HM (
β
= −0.000002,
P
= 0.10) and fine motor scores. No statistical difference between the sexes was observed. Postnatal exposure to organochlorine pesticides in HM shows a positive association with the trajectory of head circumference-for-age
z
-score and a negative association with the trajectories of fine motor skills scores. Future studies on POP variation in HM at different postpartum times and their effect on infant growth and development should be encouraged.</description><identifier>ISSN: 1614-7499</identifier><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-023-30316-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>adults ; Age ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bioaccumulation ; Body measurements ; Brazil ; Breast milk ; Circumferences ; DDE (pesticide) ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Gas chromatography ; HCH (pesticide) ; head ; Hexachlorocyclohexane ; infant development ; infant growth ; Infants ; Mass spectrometry ; Mass spectroscopy ; Motor skill ; Organic compounds ; Organochlorine compounds ; Organochlorine pesticides ; Persistent organic pollutants ; Pesticides ; Pollutants ; Postpartum ; Postpartum period ; Research Article ; Standard scores ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2023-11, Vol.30 (54), p.115050-115063</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-a50662e80c52ac66259e84f249318f22ded84748c3743cf2cab77d22cc2dcadc3</citedby><cites>FETCH-LOGICAL-c385t-a50662e80c52ac66259e84f249318f22ded84748c3743cf2cab77d22cc2dcadc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-023-30316-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-023-30316-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Ferreira, Ana Lorena Lima</creatorcontrib><creatorcontrib>Freitas-Costa, Nathalia</creatorcontrib><creatorcontrib>da Silva Rosa Freire, Samary</creatorcontrib><creatorcontrib>Figueiredo, Amanda Caroline Cunha</creatorcontrib><creatorcontrib>Padilha, Marina</creatorcontrib><creatorcontrib>Alves-Santos, Nadya Helena</creatorcontrib><creatorcontrib>Kac, Gilberto</creatorcontrib><title>Association between persistent organic pollutants in human milk and the infant growth and development throughout the first year postpartum in a cohort from Rio de Janeiro, Brazil</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><description>Persistent organic pollutants (POPs) are compounds that are recalcitrant and ubiquitous that bioaccumulate in human milk (HM) and can impact infant growth and development. We explore the association between POP concentration in HM at 2–50 days postpartum and infant growth and development trajectory throughout the first year of life. A cohort of 68 healthy adult Brazilian women and their infants were followed from 28 to 35 gestational weeks to 12 months postpartum. HM samples were collected between 2 and 50 days postpartum, and POP concentrations were analyzed using gas chromatography with mass spectrometry. Concentrations of POPs >limit of quantification (LOQ) were defined as presence, and concentrations ≤LOQ as an absence. Growth
z
-scores were analyzed according to WHO growth charts and infant development scores according to Age & Stages Questionnaires at 1 (
n
= 66), 6 (
n
= 50), and 12 months (
n
= 45). Linear mixed effects (LME) models were used to investigate the association of POPs in HM with infant growth and development. Benjamini-Hochberg (BH) correction for multiple testing was performed to reduce the false discovery ratio.
P
< 0.1 was considered for models with the interaction between POPs and time/sex. After BH correction, adjusted LME models with time interaction showed (1) a positive association between the presence of β hexachlorocyclohexane and an increase in head circumference-for-age
z
-score (
β
= 0.003,
P
= 0.095); (2) negative associations between total POPs (
β
= −0.000002,
P
= 0.10), total organochlorine pesticides (
β
= −0.000002,
P
= 0.10), and dichlorodiphenyldichloroethylene concentrations in HM (
β
= −0.000002,
P
= 0.10) and fine motor scores. No statistical difference between the sexes was observed. Postnatal exposure to organochlorine pesticides in HM shows a positive association with the trajectory of head circumference-for-age
z
-score and a negative association with the trajectories of fine motor skills scores. Future studies on POP variation in HM at different postpartum times and their effect on infant growth and development should be encouraged.</description><subject>adults</subject><subject>Age</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bioaccumulation</subject><subject>Body measurements</subject><subject>Brazil</subject><subject>Breast milk</subject><subject>Circumferences</subject><subject>DDE (pesticide)</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Gas chromatography</subject><subject>HCH (pesticide)</subject><subject>head</subject><subject>Hexachlorocyclohexane</subject><subject>infant development</subject><subject>infant growth</subject><subject>Infants</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Motor skill</subject><subject>Organic compounds</subject><subject>Organochlorine compounds</subject><subject>Organochlorine pesticides</subject><subject>Persistent organic pollutants</subject><subject>Pesticides</subject><subject>Pollutants</subject><subject>Postpartum</subject><subject>Postpartum period</subject><subject>Research Article</subject><subject>Standard scores</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution 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between persistent organic pollutants in human milk and the infant growth and development throughout the first year postpartum in a cohort from Rio de Janeiro, Brazil</title><author>Ferreira, Ana Lorena Lima ; Freitas-Costa, Nathalia ; da Silva Rosa Freire, Samary ; Figueiredo, Amanda Caroline Cunha ; Padilha, Marina ; Alves-Santos, Nadya Helena ; Kac, Gilberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-a50662e80c52ac66259e84f249318f22ded84748c3743cf2cab77d22cc2dcadc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>adults</topic><topic>Age</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bioaccumulation</topic><topic>Body measurements</topic><topic>Brazil</topic><topic>Breast milk</topic><topic>Circumferences</topic><topic>DDE (pesticide)</topic><topic>Earth and Environmental 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Lima</au><au>Freitas-Costa, Nathalia</au><au>da Silva Rosa Freire, Samary</au><au>Figueiredo, Amanda Caroline Cunha</au><au>Padilha, Marina</au><au>Alves-Santos, Nadya Helena</au><au>Kac, Gilberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between persistent organic pollutants in human milk and the infant growth and development throughout the first year postpartum in a cohort from Rio de Janeiro, Brazil</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><date>2023-11-01</date><risdate>2023</risdate><volume>30</volume><issue>54</issue><spage>115050</spage><epage>115063</epage><pages>115050-115063</pages><issn>1614-7499</issn><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Persistent organic pollutants (POPs) are compounds that are recalcitrant and ubiquitous that bioaccumulate in human milk (HM) and can impact infant growth and development. We explore the association between POP concentration in HM at 2–50 days postpartum and infant growth and development trajectory throughout the first year of life. A cohort of 68 healthy adult Brazilian women and their infants were followed from 28 to 35 gestational weeks to 12 months postpartum. HM samples were collected between 2 and 50 days postpartum, and POP concentrations were analyzed using gas chromatography with mass spectrometry. Concentrations of POPs >limit of quantification (LOQ) were defined as presence, and concentrations ≤LOQ as an absence. Growth
z
-scores were analyzed according to WHO growth charts and infant development scores according to Age & Stages Questionnaires at 1 (
n
= 66), 6 (
n
= 50), and 12 months (
n
= 45). Linear mixed effects (LME) models were used to investigate the association of POPs in HM with infant growth and development. Benjamini-Hochberg (BH) correction for multiple testing was performed to reduce the false discovery ratio.
P
< 0.1 was considered for models with the interaction between POPs and time/sex. After BH correction, adjusted LME models with time interaction showed (1) a positive association between the presence of β hexachlorocyclohexane and an increase in head circumference-for-age
z
-score (
β
= 0.003,
P
= 0.095); (2) negative associations between total POPs (
β
= −0.000002,
P
= 0.10), total organochlorine pesticides (
β
= −0.000002,
P
= 0.10), and dichlorodiphenyldichloroethylene concentrations in HM (
β
= −0.000002,
P
= 0.10) and fine motor scores. No statistical difference between the sexes was observed. Postnatal exposure to organochlorine pesticides in HM shows a positive association with the trajectory of head circumference-for-age
z
-score and a negative association with the trajectories of fine motor skills scores. Future studies on POP variation in HM at different postpartum times and their effect on infant growth and development should be encouraged.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s11356-023-30316-y</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1614-7499 |
| ispartof | Environmental science and pollution research international, 2023-11, Vol.30 (54), p.115050-115063 |
| issn | 1614-7499 0944-1344 1614-7499 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | adults Age Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bioaccumulation Body measurements Brazil Breast milk Circumferences DDE (pesticide) Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Gas chromatography HCH (pesticide) head Hexachlorocyclohexane infant development infant growth Infants Mass spectrometry Mass spectroscopy Motor skill Organic compounds Organochlorine compounds Organochlorine pesticides Persistent organic pollutants Pesticides Pollutants Postpartum Postpartum period Research Article Standard scores Waste Water Technology Water Management Water Pollution Control |
| title | Association between persistent organic pollutants in human milk and the infant growth and development throughout the first year postpartum in a cohort from Rio de Janeiro, Brazil |
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