Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes
Estimates of glucose concentrations vary among types of blood samples, which impact on the assessment of diabetes prevalence. Guidelines recommend a conversion factor to calculate plasma glucose from measurements of glucose in whole blood. The American Diabetes Association recommends the use of bloo...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2024-03, Vol.62 (4), p.762-769 |
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| creator | Heilmann, Geronimo Trenkamp, Sandra Möser, Clara Bombrich, Maria Schön, Martin Yurchenko, Iryna Strassburger, Klaus Rodríguez, Marcos Matabuena Zaharia, Oana-Patricia Burkart, Volker Wagner, Robert Roden, Michael |
| description | Estimates of glucose concentrations vary among types of blood samples, which impact on the assessment of diabetes prevalence. Guidelines recommend a conversion factor to calculate plasma glucose from measurements of glucose in whole blood. The American Diabetes Association recommends the use of blood drawing tubes containing sodium fluoride (NaF) and citrate, which have not yet been evaluated regarding possible differences in glucose concentration and conversion factors. Thus, we compared glucose measurements in NaF-citrate plasma and venous whole blood and estimated the impact of differences on diabetes and prediabetes prevalence.
Glucose differences were calculated by Bland-Altman analysis with pairwise comparison of glucose measurements from whole blood and NaF-citrate plasma (n=578) in clinical studies of the German Diabetes Center. Subsequently, we computed the impact of the glucose difference on diabetes and prediabetes prevalence in the population-based National Health and Nutrition Examination Survey (NHANES).
Even upon conversion of whole blood to plasma glucose concentrations using the recommended conversion factor, mean glucose concentration difference remained 4.72 % higher in NaF-citrate plasma. Applying the higher glucose estimates, increases the population-based diabetes and prediabetes prevalence by 13.67 and 33.97 % or more than 7.2 and 13 million people in NHANES, respectively. Additional economic burden could be about 20 $ billion per year due to undiagnosed diabetes.
The recommended conversion factor is not valid for NaF-citrate plasma. Systematic bias of glucose measurements due to sampling type leads to clinically relevant higher estimates of diabetes and prediabetes prevalence. |
| doi_str_mv | 10.1515/cclm-2023-0770 |
| format | Article |
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Glucose differences were calculated by Bland-Altman analysis with pairwise comparison of glucose measurements from whole blood and NaF-citrate plasma (n=578) in clinical studies of the German Diabetes Center. Subsequently, we computed the impact of the glucose difference on diabetes and prediabetes prevalence in the population-based National Health and Nutrition Examination Survey (NHANES).
Even upon conversion of whole blood to plasma glucose concentrations using the recommended conversion factor, mean glucose concentration difference remained 4.72 % higher in NaF-citrate plasma. Applying the higher glucose estimates, increases the population-based diabetes and prediabetes prevalence by 13.67 and 33.97 % or more than 7.2 and 13 million people in NHANES, respectively. Additional economic burden could be about 20 $ billion per year due to undiagnosed diabetes.
The recommended conversion factor is not valid for NaF-citrate plasma. Systematic bias of glucose measurements due to sampling type leads to clinically relevant higher estimates of diabetes and prediabetes prevalence.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2023-0770</identifier><identifier>PMID: 37870928</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Blood ; blood glucose ; Blood Glucose - analysis ; Citrates ; Citric Acid ; Cross-sectional studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; diabetes prevalence ; Diagnostic tests ; diagnostic thresholds ; Estimates ; Fluorides ; Glucose ; glucose metabolism ; Glycolysis ; Humans ; Mathematical analysis ; Metabolism ; Nutrition Surveys ; Plasma ; Prediabetic State - diagnosis ; Prediabetic State - epidemiology ; Prevalence ; Sodium ; Sodium Citrate ; Sodium Fluoride ; Tubes</subject><ispartof>Clinical chemistry and laboratory medicine, 2024-03, Vol.62 (4), p.762-769</ispartof><rights>2023 the author(s), published by De Gruyter, Berlin/Boston.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c331t-152197c806eb431636b632629b4425cb1a475ef6676ee7b9cb8d87f0bc3d45943</cites><orcidid>0000-0001-8200-6382</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2023-0770/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2023-0770/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,66497,68281</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37870928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heilmann, Geronimo</creatorcontrib><creatorcontrib>Trenkamp, Sandra</creatorcontrib><creatorcontrib>Möser, Clara</creatorcontrib><creatorcontrib>Bombrich, Maria</creatorcontrib><creatorcontrib>Schön, Martin</creatorcontrib><creatorcontrib>Yurchenko, Iryna</creatorcontrib><creatorcontrib>Strassburger, Klaus</creatorcontrib><creatorcontrib>Rodríguez, Marcos Matabuena</creatorcontrib><creatorcontrib>Zaharia, Oana-Patricia</creatorcontrib><creatorcontrib>Burkart, Volker</creatorcontrib><creatorcontrib>Wagner, Robert</creatorcontrib><creatorcontrib>Roden, Michael</creatorcontrib><title>Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>Estimates of glucose concentrations vary among types of blood samples, which impact on the assessment of diabetes prevalence. Guidelines recommend a conversion factor to calculate plasma glucose from measurements of glucose in whole blood. The American Diabetes Association recommends the use of blood drawing tubes containing sodium fluoride (NaF) and citrate, which have not yet been evaluated regarding possible differences in glucose concentration and conversion factors. Thus, we compared glucose measurements in NaF-citrate plasma and venous whole blood and estimated the impact of differences on diabetes and prediabetes prevalence.
Glucose differences were calculated by Bland-Altman analysis with pairwise comparison of glucose measurements from whole blood and NaF-citrate plasma (n=578) in clinical studies of the German Diabetes Center. Subsequently, we computed the impact of the glucose difference on diabetes and prediabetes prevalence in the population-based National Health and Nutrition Examination Survey (NHANES).
Even upon conversion of whole blood to plasma glucose concentrations using the recommended conversion factor, mean glucose concentration difference remained 4.72 % higher in NaF-citrate plasma. Applying the higher glucose estimates, increases the population-based diabetes and prediabetes prevalence by 13.67 and 33.97 % or more than 7.2 and 13 million people in NHANES, respectively. Additional economic burden could be about 20 $ billion per year due to undiagnosed diabetes.
The recommended conversion factor is not valid for NaF-citrate plasma. 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Guidelines recommend a conversion factor to calculate plasma glucose from measurements of glucose in whole blood. The American Diabetes Association recommends the use of blood drawing tubes containing sodium fluoride (NaF) and citrate, which have not yet been evaluated regarding possible differences in glucose concentration and conversion factors. Thus, we compared glucose measurements in NaF-citrate plasma and venous whole blood and estimated the impact of differences on diabetes and prediabetes prevalence.
Glucose differences were calculated by Bland-Altman analysis with pairwise comparison of glucose measurements from whole blood and NaF-citrate plasma (n=578) in clinical studies of the German Diabetes Center. Subsequently, we computed the impact of the glucose difference on diabetes and prediabetes prevalence in the population-based National Health and Nutrition Examination Survey (NHANES).
Even upon conversion of whole blood to plasma glucose concentrations using the recommended conversion factor, mean glucose concentration difference remained 4.72 % higher in NaF-citrate plasma. Applying the higher glucose estimates, increases the population-based diabetes and prediabetes prevalence by 13.67 and 33.97 % or more than 7.2 and 13 million people in NHANES, respectively. Additional economic burden could be about 20 $ billion per year due to undiagnosed diabetes.
The recommended conversion factor is not valid for NaF-citrate plasma. Systematic bias of glucose measurements due to sampling type leads to clinically relevant higher estimates of diabetes and prediabetes prevalence.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>37870928</pmid><doi>10.1515/cclm-2023-0770</doi><tpages>08</tpages><orcidid>https://orcid.org/0000-0001-8200-6382</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood blood glucose Blood Glucose - analysis Citrates Citric Acid Cross-sectional studies Diabetes Diabetes mellitus Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology diabetes prevalence Diagnostic tests diagnostic thresholds Estimates Fluorides Glucose glucose metabolism Glycolysis Humans Mathematical analysis Metabolism Nutrition Surveys Plasma Prediabetic State - diagnosis Prediabetic State - epidemiology Prevalence Sodium Sodium Citrate Sodium Fluoride Tubes |
| title | Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes |
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