Validation of Modaplex POLE mutation assay in endometrial carcinoma

The TCGA-based molecular classification of endometrial cancer has emerged as an important tool to stratify patients according to prognosis. A simplified scheme has been proposed, by using immunohistochemistry for p53, MSH6, and PMS2 and a molecular test for POLE mutations (NGS or Sanger sequencing,...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2023-12, Vol.483 (6), p.787-794
Hauptverfasser:	Dorca, Eduard, Velasco, Ana, Varela, Mar, Gatius, Sonia, Villatoro, Sergio, Fullana, Neus, Cuevas, Dolors, Vaquero, Marta, Birnbaum, Astrid, Neumann, Karsten, Matias-Guiu, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Capillary electrophoresis Carcinoma Electrophoresis Endometrial cancer Endometrial Neoplasms - diagnosis Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Endometrium Female Humans Immunohistochemistry Medicine Medicine & Public Health MSH6 protein Mutation Original Article Pathology Poly-ADP-Ribose Binding Proteins - genetics Polymerase chain reaction Predictive Value of Tests Retrospective Studies Sensitivity analysis Sensitivity and Specificity Subgroups Tumors Uterine cancer
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