Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice
There are currently insufficient anthelmintic medications available for the treatment of toxocariasis. For instance, Albendazole (ABZ) is the preferred medication, but its effectiveness against tissue-dwelling parasites is limited. In addition, Metformin (MTF) is a widely used oral antidiabetic medi...
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| Veröffentlicht in: | Parasitology research (1987) 2023-12, Vol.122 (12), p.3213-3231 |
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| container_title | Parasitology research (1987) |
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| creator | Salama, Amina M. Elmahy, Rasha A. Ibrahim, Hoda A. Amer, Alaa Ibrahim Mohamed Eltantawy, Asmaa Fawzy Elgendy, Dina I. |
| description | There are currently insufficient anthelmintic medications available for the treatment of toxocariasis. For instance, Albendazole (ABZ) is the preferred medication, but its effectiveness against tissue-dwelling parasites is limited. In addition, Metformin (MTF) is a widely used oral antidiabetic medication that is considered to be safe for treatment. This study aimed to investigate any potential effects of MTF, alone or in combination with ABZ, on mice infections caused by
Toxocara canis
(
T. canis
). The efficacy of the treatment was assessed in the acute and chronic phases of the infection by larval recovery and histopathological, immunohistochemical, and biochemical studies. The results showed that combined therapy significantly reduced larval counts in the liver, brain, and muscles and ameliorated hepatic and brain pathology. It reduced oxidative stress and TGF-β mRNA expression and increased FGF21 levels in the liver. It decreased TNF-α levels and MMP-9 expression in the brain. In addition, it increased serum levels of IL-12 and IFN-γ and decreased serum levels of IL-4 and IL-10. In the acute and chronic phases of the infection, the combined treatment was more effective than ABZ alone. In conclusion, this study highlights the potential role of MTF as an adjuvant in the treatment of experimental
T. canis
infection when administered with ABZ. |
| doi_str_mv | 10.1007/s00436-023-08011-1 |
| format | Article |
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Toxocara canis
(
T. canis
). The efficacy of the treatment was assessed in the acute and chronic phases of the infection by larval recovery and histopathological, immunohistochemical, and biochemical studies. The results showed that combined therapy significantly reduced larval counts in the liver, brain, and muscles and ameliorated hepatic and brain pathology. It reduced oxidative stress and TGF-β mRNA expression and increased FGF21 levels in the liver. It decreased TNF-α levels and MMP-9 expression in the brain. In addition, it increased serum levels of IL-12 and IFN-γ and decreased serum levels of IL-4 and IL-10. In the acute and chronic phases of the infection, the combined treatment was more effective than ABZ alone. In conclusion, this study highlights the potential role of MTF as an adjuvant in the treatment of experimental
T. canis
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Toxocara canis
(
T. canis
). The efficacy of the treatment was assessed in the acute and chronic phases of the infection by larval recovery and histopathological, immunohistochemical, and biochemical studies. The results showed that combined therapy significantly reduced larval counts in the liver, brain, and muscles and ameliorated hepatic and brain pathology. It reduced oxidative stress and TGF-β mRNA expression and increased FGF21 levels in the liver. It decreased TNF-α levels and MMP-9 expression in the brain. In addition, it increased serum levels of IL-12 and IFN-γ and decreased serum levels of IL-4 and IL-10. In the acute and chronic phases of the infection, the combined treatment was more effective than ABZ alone. In conclusion, this study highlights the potential role of MTF as an adjuvant in the treatment of experimental
T. canis
infection when administered with ABZ.</description><subject>Albendazole</subject><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Chronic infection</subject><subject>Diabetes mellitus</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Hypoglycemic agents</subject><subject>Immunology</subject><subject>Infections</subject><subject>Interleukins</subject><subject>Liver</subject><subject>Medical Microbiology</subject><subject>Metformin</subject><subject>Microbiology</subject><subject>Muscles</subject><subject>Oxidative stress</subject><subject>RNA</subject><subject>Roundworm infections</subject><subject>Serum levels</subject><subject>Toxocariasis</subject><subject>Transforming growth factor-b</subject><subject>Transforming growth factors</subject><subject>Tumor necrosis factor-α</subject><subject>γ-Interferon</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kc9u1DAQxiMEEkvhBThF4sKBlPG_xDlWVYFKlbj0bjn2ZNdVYgfbqeA5eOE6u9AKhJAPHo9_38zYX1W9JXBOALqPCYCztgHKGpBASEOeVTvCGW1IL8Tzagd9icsFe1m9SukOgHQt57vq59U4osmpDmM9Yx5DnJ2vg68XHXVyOUxh74yePpREPvw-1eag_R5TXdh8wHqIukTa23py9xiPkZvn1T8KdFqObewand_X9y4ZjCWfw_dgdHSl17Ha7Ay-rl6Mekr45td-Vt1-urq9_NLcfP18fXlx0xhOeG4GaokVRgokhlphtUBurGUDdkxCK7q-FW2HzDCQBOjQMzt2A0hje1G-hp1V709llxi-rZiymreppkl7DGtSVEpCuRBcFvTdX-hdWKMvwxWqp70EIfsnaq8nVM6PIUdttqLqous4MMFho87_QZVlsTw-eBxdyf8hoCeBiSGliKNaopt1_KEIqM19dXJfFffV0X1FioidRGnZPhzj08T_UT0Aw3yy-A</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Salama, Amina M.</creator><creator>Elmahy, Rasha A.</creator><creator>Ibrahim, Hoda A.</creator><creator>Amer, Alaa Ibrahim Mohamed</creator><creator>Eltantawy, Asmaa Fawzy</creator><creator>Elgendy, Dina I.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8230-6761</orcidid><orcidid>https://orcid.org/0000-0002-0070-6113</orcidid><orcidid>https://orcid.org/0000-0003-0487-5659</orcidid><orcidid>https://orcid.org/0000-0001-7707-1796</orcidid><orcidid>https://orcid.org/0000-0002-6754-6214</orcidid></search><sort><creationdate>20231201</creationdate><title>Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice</title><author>Salama, Amina M. ; Elmahy, Rasha A. ; Ibrahim, Hoda A. ; Amer, Alaa Ibrahim Mohamed ; Eltantawy, Asmaa Fawzy ; Elgendy, Dina I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-b2d1d5c85e1c2d5da5e4cdd3be738065796567e3c308102b93df7b08cd951433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Albendazole</topic><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Chronic infection</topic><topic>Diabetes mellitus</topic><topic>Gelatinase B</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Hypoglycemic agents</topic><topic>Immunology</topic><topic>Infections</topic><topic>Interleukins</topic><topic>Liver</topic><topic>Medical Microbiology</topic><topic>Metformin</topic><topic>Microbiology</topic><topic>Muscles</topic><topic>Oxidative stress</topic><topic>RNA</topic><topic>Roundworm infections</topic><topic>Serum levels</topic><topic>Toxocariasis</topic><topic>Transforming growth factor-b</topic><topic>Transforming growth factors</topic><topic>Tumor necrosis factor-α</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salama, Amina M.</creatorcontrib><creatorcontrib>Elmahy, Rasha A.</creatorcontrib><creatorcontrib>Ibrahim, Hoda A.</creatorcontrib><creatorcontrib>Amer, Alaa Ibrahim Mohamed</creatorcontrib><creatorcontrib>Eltantawy, Asmaa Fawzy</creatorcontrib><creatorcontrib>Elgendy, Dina I.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salama, Amina M.</au><au>Elmahy, Rasha A.</au><au>Ibrahim, Hoda A.</au><au>Amer, Alaa Ibrahim Mohamed</au><au>Eltantawy, Asmaa Fawzy</au><au>Elgendy, Dina I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>122</volume><issue>12</issue><spage>3213</spage><epage>3231</epage><pages>3213-3231</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>There are currently insufficient anthelmintic medications available for the treatment of toxocariasis. 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Toxocara canis
(
T. canis
). The efficacy of the treatment was assessed in the acute and chronic phases of the infection by larval recovery and histopathological, immunohistochemical, and biochemical studies. The results showed that combined therapy significantly reduced larval counts in the liver, brain, and muscles and ameliorated hepatic and brain pathology. It reduced oxidative stress and TGF-β mRNA expression and increased FGF21 levels in the liver. It decreased TNF-α levels and MMP-9 expression in the brain. In addition, it increased serum levels of IL-12 and IFN-γ and decreased serum levels of IL-4 and IL-10. In the acute and chronic phases of the infection, the combined treatment was more effective than ABZ alone. In conclusion, this study highlights the potential role of MTF as an adjuvant in the treatment of experimental
T. canis
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| fulltext | fulltext |
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| ispartof | Parasitology research (1987), 2023-12, Vol.122 (12), p.3213-3231 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2881245548 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Albendazole Analysis Biomedical and Life Sciences Biomedicine Brain Chronic infection Diabetes mellitus Gelatinase B Gene expression Health aspects Hypoglycemic agents Immunology Infections Interleukins Liver Medical Microbiology Metformin Microbiology Muscles Oxidative stress RNA Roundworm infections Serum levels Toxocariasis Transforming growth factor-b Transforming growth factors Tumor necrosis factor-α γ-Interferon |
| title | Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice |
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