A truncated HIV Tat demonstrates potent and specific latency reversal activity

A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent reservoir is capable of producing replication-competent infectious viruses once prolonged suppressive cART is withdrawn. Inducing the reactiv...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2023-11, Vol.67 (11), p.e0041723
Hauptverfasser:	Van Gulck, Ellen, Pardons, Marion, Nijs, Erik, Verheyen, Nick, Dockx, Koen, Van Den Eynde, Christel, Battivelli, Emilie, Vega, Jerel, Florence, Eric, Autran, Brigitte, Archin, Nancie M, Margolis, David M, Katlama, Christine, Hamimi, Chiraz, Van Den Wyngaert, Ilse, Eyassu, Filmon, Vandekerckhove, Linos, Boden, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes HIV Infections Humans Proviruses - genetics Virus Activation Virus Latency Virus Replication
Online-Zugang:	Volltext
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