Activating mutations drive human MEK1 kinase using a gear-shifting mechanism

There is an unmet need to classify cancer-promoting kinase mutations in a mechanistically cognizant way. The challenge is to understand how mutations stabilize different kinase configurations to alter function, and how this influences pathogenic potential of the kinase and its responses to therapeut...

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Veröffentlicht in:	Biochemical journal 2023-11, Vol.480 (21), p.1733-1751
Hauptverfasser:	Patil, Keshav, Wang, Yiming, Chen, Zhangtao, Suresh, Krishna, Radhakrishnan, Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Gain of Function Mutation Humans Mutation Neoplasms - metabolism
Online-Zugang:	Volltext
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