Acid hydrolysis conditions for quantification of meningococcal X polysaccharide in a pentavalent vaccine using HPAEC-PAD/ESI-MS

A selective and sensitive method was evaluated for quantitation of meningococcal X (Men X) polysaccharide in pentavalent meningococcal A, C, W, Y and X conjugate vaccine using different acid hydrolysis conditions like HCl, TFA, HF, HF-TFA, and HF–HCl. High-performance anion exchange chromatography w...

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Veröffentlicht in:	Analytical biochemistry 2023-12, Vol.683, p.115363-115363, Article 115363
Hauptverfasser:	Ghosh, Saurav, Pawar, Rakesh, Kangralkar, Vivek, Mallya, Asha D., Dhere, Rajeev M., Bolgiano, Barbara, Ravenscroft, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Hydrolysis Carbohydrate-based vaccine Chromatography, Ion Exchange - methods Electrospray mass spectroscopy Glucosamine HPAEC-PAD Humans Hydrolysis Meningococcal A, C, W, Y, and X polysaccharides Meningococcal Vaccines - analysis Meningococcal Vaccines - chemistry Neisseria meningitidis Polysaccharides, Bacterial - analysis Polysaccharides, Bacterial - chemistry Tandem Mass Spectrometry Vaccines, Combined
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