Synthesis and preclinical evaluation of a selective MET kinase positron emission tomography tracer

The tyrosine kinase MET (hepatocyte growth factor receptor) is activated or mutated in a wide range of cancers and is often correlated with a poor prognosis. Precision medicine with positron emission tomography (PET) can potentially aid in the assessment of tumor biochemistry and heterogeneity, whic...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2023-12, Vol.66 (14), p.452-460
Hauptverfasser:	Lien, Vegard Torp, Hauge, Emily, Nuruddin, Syed, Klaveness, Jo, Olberg, Dag Erlend
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography c-Met protein Emission analysis Fluorine isotopes Fluorine Radioisotopes fluoroethyl tosylate Growth factors Hepatocyte growth factor Heterogeneity in vivo evaluation Kinases MET kinase Mice Neoplasms PET imaging Positron emission Positron emission tomography Positron-Emission Tomography - methods Precision medicine Protein-tyrosine kinase Proto-Oncogene Proteins c-met Radioactive tracers Radiochemistry Tissue Distribution Tomography Tumors Tyrosine
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