Co-expression of IL-4/IL-15-based inverted cytokine receptor in CAR-T cells overcomes IL-4 signaling in immunosuppressive pancreatic tumor microenvironment

The efficacy of CAR-T cell therapy has been hindered by several factors that are intrinsic to the tumor microenvironment. Many strategies are being employed to overcome these barriers and improve immunotherapies efficacy. Interleukin (IL)− 4 is a cytokine released by tumor cells inside the tumor mic...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-12, Vol.168, p.115740-115740, Article 115740
Hauptverfasser:	Zhou, Ying, Farooq, Muhammad Asad, Ajmal, Iqra, He, Cong, Gao, Yaoxin, Guo, Dandan, Duan, Yixin, Jiang, Wenzheng
Format:	Artikel
Sprache:	eng
Schlagworte:	CAR-T therapy Inverted cytokine receptor (ICR) NKG2D-CAR-T Pancreatic cancer Tumor microenvironment
Online-Zugang:	Volltext
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