Dynamics and recognition of homeodomain containing protein-DNA complex of IRX4

Iroquois Homeobox 4 (IRX4) belongs to a family of homeobox TFs having roles in embryogenesis, cell specification, and organ development. Recently, large scale genome-wide association studies and epigenetic studies have highlighted the role of IRX4 and its associated variants in prostate cancer. No s...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2024-02, Vol.92 (2), p.282-301
Hauptverfasser:	Malik, Adil, Jayarathna, Dulari K, Fisher, Mark, Barbhuiya, Tabassum Khair, Gandhi, Neha S, Batra, Jyotsna
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Ascitic fluid Binding Conserved sequence Deoxyribonucleic acid DNA DNA structure Dynamic structural analysis Embryogenesis Embryonic growth stage Epigenetics Gene expression Genomes Homeobox Homogeneity Homology Hydrogen bonding Iroquois protein Lymphocytes B Modularity Molecular dynamics Mutation Native North Americans Nucleotide sequence Peptides Prostate Prostate cancer Protein structure Proteins Recognition Residues Secondary structure Sequence analysis Tumor cell lines
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