Timosaponin AIII Induces Lipid Peroxidation and Ferroptosis by Enhancing Rab7-Mediated Lipophagy in Colorectal Cancer Cells

•Colorectal cancer cells treated with TA-III exhibit Rab7-Mediated ferroptosis, as demonstrated for the first time by our study.•The process of lipophagy triggers the breakdown of lipid droplets, leading to the induction of lipid peroxidation and subsequent ferroptotic cell death.•The accumulation o...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-01, Vol.122, p.155079-155079, Article 155079
Hauptverfasser:	Shen, Chenjie, Liu, Jinging, Liu, Huan, Li, Guifang, Wang, Hanyu, Tian, Haixia, Mao, Yong, Hua, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal cancer Ferroptosis Lipophagy Rab7
Online-Zugang:	Volltext
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