Hypoxia ischemia results in blood brain barrier damage via AKT/GSK-3β/CREB pathway in neonatal rats

[Display omitted] •The brain damage after HI can be monitored by MRI in vivo.•The Akt/GSK-3β/CREB pathway participates in damaged BBB after HI.•HI upregulates MMP-9 expression and results in BBB disruption. Previous studies have showed that the permeability of blood brain barrier (BBB) increased aft...

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Veröffentlicht in:	Brain research 2024-01, Vol.1822, p.148640-148640, Article 148640
Hauptverfasser:	Liu, Chenmeng, Wang, Can, Zhang, Haimo, Gao, Xiaotian, Xiao, Peilun, Yu, Miao, Wang, Xin, Wang, Xizhen, Wang, Xiaoli
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT/GSK-3β/CREB pathway Animals Animals, Newborn Blood brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Claudin-5 - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Glycogen Synthase Kinase 3 beta - metabolism Hypoxia-Ischemia, Brain - metabolism Hypoxic-ischemic brain damage Ischemia - complications Ischemia - metabolism Matrix Metalloproteinase 9 - metabolism Neonatal rats Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley
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