Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis

Abnormal accumulation of senescent cells in tissues has been shown to facilitate the onset and progression of various diseases. As an important protein involving in the regulation of cellular senescence process, researches suggested GRSF1 as a potential senolytic target to improve multiple physiolog...

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Veröffentlicht in:	Molecular neurobiology 2024-04, Vol.61 (4), p.2151-2164
Hauptverfasser:	Li, Yanan, Shen, Qianni, Huang, Lidan, Li, Bingyu, Zhang, Yuxi, Wang, Wei, Zhao, Bo, Gao, Wenwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Apoptosis Biomedical and Life Sciences Biomedicine Cell Biology Ferroptosis Ischemia Neurobiology Neurology Neurosciences Oxidative metabolism Oxidative stress Phenotypes Reperfusion Senescence Therapeutic targets Tumor necrosis factor-α
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