Characterization of the responses of brain macrophages to focused ultrasound-mediated blood–brain barrier opening

The opening of the blood–brain barrier (BBB) by focused ultrasound (FUS) coupled with intravenously injected microbubbles can be leveraged as a form of immunotherapy for the treatment of neurodegenerative disorders. However, how FUS BBB opening affects brain macrophages is not well understood. Here...

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Veröffentlicht in:	Nature biomedical engineering 2024-05, Vol.8 (5), p.650-663
Hauptverfasser:	Kline-Schoder, Alina R., Chintamen, Sana, Willner, Moshe J., DiBenedetto, Melody R., Noel, Rebecca L., Batts, Alec J., Kwon, Nancy, Zacharoulis, Stergios, Wu, Cheng-Chia, Menon, Vilas, Kernie, Steven G., Konofagou, Elisa E.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 59 59/57 631/378/1341 631/61/514/1949 64 64/60 82 Animals Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Blood-brain barrier Blood-Brain Barrier - metabolism Brain Cell Proliferation Central nervous system Female Gliogenesis Immunotherapy Macrophages Macrophages - metabolism Male Mice Mice, Inbred C57BL Microbubbles Microglia Microglia - metabolism Nervous system Neurodegenerative diseases Phagocytosis Sequences Single-Cell Analysis - methods Ultrasonic imaging Ultrasonic Waves Ultrasound
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