Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc)

Efmarodocokin alfa (IL-22Fc) is a fusion protein of human IL-22 linked to the crystallizable fragment (Fc) of human IgG4. It has been tested in multiple indications including inflammatory bowel disease (IBD). The purposes of the present analyses were to describe the population pharmacokinetics (PK)...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2024-04, Vol.51 (2), p.141-153
Hauptverfasser:	Yu, Yanke, Rothenberg, Michael E., Ding, Han Ting, Brekkan, Ari, Sperinde, Gizette, Harder, Brandon, Zhang, Rong, Owen, Ryan, Kassir, Nastya, Lekkerkerker, Annemarie N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Body Weight C-Reactive Protein Fusion protein Humans Immunoglobulin G Inflammatory bowel disease Inflammatory Bowel Diseases Models, Biological Original Paper Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacy Population studies Veterinary Medicine/Veterinary Science
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