Synergy between Interleukin-1 β , Interferon- γ , and Glucocorticoids to Induce TLR2 Expression Involves NF- κ B, STAT1, and the Glucocorticoid Receptor

Glucocorticoids act via the glucocorticoid receptor (GR; NR3C1) to downregulate inflammatory gene expression and are effective treatments for mild to moderate asthma. However, in severe asthma and virus-induced exacerbations, glucocorticoid therapies are less efficacious, possibly due to reduced rep...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular pharmacology 2023-12, Vol.105 (1), p.23-38
Hauptverfasser:	Bansal, Akanksha, Kooi, Cora, Kalyanaraman, Keerthana, Gill, Sachman, Thorne, Andrew, Chandramohan, Priyanka, Necker-Brown, Amandah, Mostafa, Mahmoud M, Milani, Arya, Leigh, Richard, Newton, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Cytokines - metabolism Dexamethasone - pharmacology Glucocorticoids - pharmacology Humans Interferon-gamma - metabolism Interferon-gamma - pharmacology Interleukin-1beta - metabolism NF-kappa B - metabolism Receptors, Glucocorticoid - metabolism STAT1 Transcription Factor - metabolism Toll-Like Receptor 2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!