Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance

Nociceptor cell bodies generate "spontaneous" discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent and human dorsal root ganglia have shown that previo...

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Veröffentlicht in:	Pain (Amsterdam) 2024-04, Vol.165 (4), p.893-907
Hauptverfasser:	Tian, Jinbin, Bavencoffe, Alexis G, Zhu, Michael X, Walters, Edgar T
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Cell Body Ganglia, Spinal - metabolism Humans Ion Channels - metabolism Mice Nociceptors Pain - metabolism Rats Rats, Sprague-Dawley TRPM Cation Channels - metabolism
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