Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation

Light chain amyloidosis (AL) is a systemic disease where fibrillar deposition of misfolded immunoglobulin light chains (LCs) severely affects organ function and results in poor prognosis for patients, especially when heart involvement is severe. Particularly relevant in this context is the cardiotox...

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Veröffentlicht in:	Journal of molecular biology 2023-12, Vol.435 (24), p.168320-168320, Article 168320
Hauptverfasser:	Broggini, Luca, Barzago, Maria Monica, Speranzini, Valentina, Schulte, Tim, Sonzini, Federica, Giono, Matteo, Romeo, Margherita, Milani, Paolo, Caminito, Serena, Mazzini, Giulia, Rognoni, Paola, Merlini, Giampaolo, Pappone, Carlo, Anastasia, Luigi, Nuvolone, Mario, Palladini, Giovanni, Diomede, Luisa, Ricagno, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - immunology Animals Caenorhabditis elegans Humans Immunoglobulin Light Chains - chemistry Immunoglobulin Light Chains - immunology Immunoglobulin Light Chains - therapeutic use Immunoglobulin Light-chain Amyloidosis - immunology Immunoglobulin Light-chain Amyloidosis - therapy Myocytes, Cardiac - metabolism Single-Domain Antibodies - chemistry Single-Domain Antibodies - immunology Single-Domain Antibodies - therapeutic use
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