Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty

In this double-blind, randomized trial, vancomycin was added to cefazolin as surgical prophylaxis for arthroplasty. Surgical-site infections occurred in 4.5% of vancomycin recipients and 3.5% of placebo recipients.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-10, Vol.389 (16), p.1488-1498
Hauptverfasser:	Peel, Trisha N., Astbury, Sarah, Cheng, Allen C., Paterson, David L., Buising, Kirsty L., Spelman, Tim, Tran-Duy, An, Adie, Sam, Boyce, Glenn, McDougall, Catherine, Molnar, Robert, Mulford, Jonathan, Rehfisch, Peter, Solomon, Michael, Crawford, Ross, Harris-Brown, Tiffany, Roney, Janine, Wisniewski, Jessica, de Steiger, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis - adverse effects Antibiotic Prophylaxis - methods Antibiotics Antimicrobial agents Arthroplasty (hip) Arthroplasty (knee) Arthroplasty, Replacement - adverse effects Arthroplasty, Replacement - methods Arthroplasty, Replacement - statistics & numerical data Arthroplasty, Replacement, Knee - adverse effects Arthroplasty, Replacement, Knee - methods Australia Bacterial Infections Cefazolin Cefazolin - adverse effects Cefazolin - therapeutic use Clinical trials Colonization Confidence intervals Coronaviruses COVID-19 Disease prevention Double-Blind Method Drug resistance Global Health Hospital costs Humans Infectious Disease Infectious Disease General Joint surgery Medical research Methicillin Methicillin-Resistant Staphylococcus aureus Orthopedics Orthopedics General Patients Placebos Prophylaxis Staphylococcal Infections - drug therapy Staphylococcal Infections - epidemiology Staphylococcal Infections - prevention & control Staphylococcus aureus Staphylococcus infections Statistical analysis Surgery Surgery General Surgical site infections Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Surgical Wound Infection - prevention & control Vancomycin Vancomycin - adverse effects Vancomycin - therapeutic use β-Lactam antibiotics
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Beschreibung
Zusammenfassung:	In this double-blind, randomized trial, vancomycin was added to cefazolin as surgical prophylaxis for arthroplasty. Surgical-site infections occurred in 4.5% of vancomycin recipients and 3.5% of placebo recipients.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2301401