Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway

•Butyrate levels exhibited a decreasing trend with the progression of CKD.•Butyrate alleviated renal fibrosis in CKD mice.•Butyrate suppressed NLRP3-mediated pyroptosis.•Butyrate inhibited NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway. Chronic kidney disease (CKD) is a serious and irreve...

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Veröffentlicht in:	International immunopharmacology 2023-11, Vol.124, p.111010-111010, Article 111010
Hauptverfasser:	Tian, Xiaofang, Zeng, Yizhou, Tu, Qingxian, Jiao, Yang, Yao, Song, Chen, Ying, Sun, Li, Xia, Qianhang, Luo, Yadan, Yuan, Liying, Jiang, Qianfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	NF-κB/p65 NLRP3 inflammasome Pyroptosis Renal fibrosis Short-chain fatty acids
Online-Zugang:	Volltext
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