Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA?

Epilepsy is a chronic neurological disease with recurrent seizures. Increasing evidence suggests that endoplasmic reticulum (ER) stress may play a role in the pathogenesis of epilepsy. We aimed to investigate the effects of Tauroursodeoxycholic acid (TUDCA) and 4-phenyl-butyric acid (4-PBA), which a...

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Veröffentlicht in:	European journal of pharmacology 2023-12, Vol.960, p.176072-176072, Article 176072
Hauptverfasser:	Doğanyiğit, Züleyha, Okan, Aslı, Akyüz, Enes, Yılmaz, Seher, Ateş, Şükrü, Taheri, Serpil, Yılmaz, Zeynep, Shaikh, Mohd. Farooq
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Oxidative stress Seizure TUDCA Unfolded protein response
Online-Zugang:	Volltext
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