Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023

Background The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care were updated. Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first‐line treatment options for antiretroviral treatment (ART)‐...

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Veröffentlicht in:HIV medicine 2023-11, Vol.24 (11), p.1126-1136
Hauptverfasser: Ambrosioni, Juan, Levi, Laura, Alagaratnam, Jasmini, Van Bremen, Kathrin, Mastrangelo, Andrea, Waalewijn, Hylke, Molina, Jean‐Michel, Guaraldi, Giovanni, Winston, Alan, Boesecke, Christoph, Cinque, Paola, Bamford, Alasdair, Calmy, Alexandra, Marzolini, Catia, Martínez, Esteban, Oprea, Cristiana, Welch, Steven, Koval, Anna, Mendao, Luis, Rockstroh, Jürgen K.
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container_end_page 1136
container_issue 11
container_start_page 1126
container_title HIV medicine
container_volume 24
creator Ambrosioni, Juan
Levi, Laura
Alagaratnam, Jasmini
Van Bremen, Kathrin
Mastrangelo, Andrea
Waalewijn, Hylke
Molina, Jean‐Michel
Guaraldi, Giovanni
Winston, Alan
Boesecke, Christoph
Cinque, Paola
Bamford, Alasdair
Calmy, Alexandra
Marzolini, Catia
Martínez, Esteban
Oprea, Cristiana
Welch, Steven
Koval, Anna
Mendao, Luis
Rockstroh, Jürgen K.
description Background The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care were updated. Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first‐line treatment options for antiretroviral treatment (ART)‐naïve adults as versions 11.0 and 11.1: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long‐acting section has been expanded in the ART and drug–drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti‐infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient‐reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir‐free two‐drug regimens in people with isolated anti‐hepatitis B core antibodies are provided. In the opportunistic infections and COVID‐19 panel, guidance on the management of COVID‐19 in people with HIV has been updated according to the most up‐to‐date evidence, and a new section on monkeypox has been added. Conclusions In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.
doi_str_mv 10.1111/hiv.13542
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Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first‐line treatment options for antiretroviral treatment (ART)‐naïve adults as versions 11.0 and 11.1: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long‐acting section has been expanded in the ART and drug–drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti‐infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient‐reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir‐free two‐drug regimens in people with isolated anti‐hepatitis B core antibodies are provided. In the opportunistic infections and COVID‐19 panel, guidance on the management of COVID‐19 in people with HIV has been updated according to the most up‐to‐date evidence, and a new section on monkeypox has been added. Conclusions In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.</description><identifier>ISSN: 1464-2662</identifier><identifier>ISSN: 1468-1293</identifier><identifier>EISSN: 1468-1293</identifier><identifier>DOI: 10.1111/hiv.13542</identifier><identifier>PMID: 37849432</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Abacavir ; Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - drug therapy ; Adolescent ; Adolescents ; Adult ; AIDS ; AIDS-Related Opportunistic Infections - drug therapy ; Algorithms ; Anti-HIV Agents - therapeutic use ; Anti-Retroviral Agents - therapeutic use ; Antibodies ; Antiretroviral agents ; Antiretroviral therapy ; Breast feeding ; Cancer screening ; Child ; Cognitive ability ; Comorbidity ; COVID-19 ; Diabetes mellitus ; Disease transmission ; Drug interaction ; Drug interactions ; EACS ; Emtricitabine ; European AIDS Clinical Society ; Guidelines ; Hepatitis ; Hepatitis B ; Hepatitis C ; Hepatitis C - drug therapy ; HIV ; HIV Infections - diagnosis ; HIV Infections - drug therapy ; Human immunodeficiency virus ; Humans ; Infections ; Integrase ; Lamivudine ; Lamivudine - therapeutic use ; major updates ; Medical screening ; Monkeypox ; Mpox ; Mpox (monkeypox) ; Practice Guidelines as Topic ; Sexual health ; Sexually transmitted diseases ; STD ; Tenofovir ; Tenofovir - therapeutic use ; V12.0 ; Vaccination ; Vaccines ; Viral diseases ; Viruses</subject><ispartof>HIV medicine, 2023-11, Vol.24 (11), p.1126-1136</ispartof><rights>2023 The Authors. published by John Wiley &amp; Sons Ltd on behalf of British HIV Association.</rights><rights>2023 The Authors. HIV Medicine published by John Wiley &amp; Sons Ltd on behalf of British HIV Association.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). 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Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first‐line treatment options for antiretroviral treatment (ART)‐naïve adults as versions 11.0 and 11.1: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long‐acting section has been expanded in the ART and drug–drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti‐infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient‐reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir‐free two‐drug regimens in people with isolated anti‐hepatitis B core antibodies are provided. In the opportunistic infections and COVID‐19 panel, guidance on the management of COVID‐19 in people with HIV has been updated according to the most up‐to‐date evidence, and a new section on monkeypox has been added. Conclusions In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.</description><subject>Abacavir</subject><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>Algorithms</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antibodies</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral therapy</subject><subject>Breast feeding</subject><subject>Cancer screening</subject><subject>Child</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>COVID-19</subject><subject>Diabetes mellitus</subject><subject>Disease transmission</subject><subject>Drug interaction</subject><subject>Drug interactions</subject><subject>EACS</subject><subject>Emtricitabine</subject><subject>European AIDS Clinical Society</subject><subject>Guidelines</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>Hepatitis C - drug therapy</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Integrase</subject><subject>Lamivudine</subject><subject>Lamivudine - therapeutic use</subject><subject>major updates</subject><subject>Medical screening</subject><subject>Monkeypox</subject><subject>Mpox</subject><subject>Mpox (monkeypox)</subject><subject>Practice Guidelines as Topic</subject><subject>Sexual health</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Tenofovir</subject><subject>Tenofovir - therapeutic use</subject><subject>V12.0</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>1464-2662</issn><issn>1468-1293</issn><issn>1468-1293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp10MtKAzEUBuAgiveFLyABN7qYNrdOkqXUqgVFpOp2yGTOaMp0UpNOpW9vbNWFYDYnHD5-Dj9CJ5T0aHr9N7fsUT4QbAvtU5GrjDLNt9d_kbE8Z3voIMYpIVRyTXbRHpdKaMHZPnq8N1MfcICli863eAlhPSnrEexrvHgDPOqCn4Np8eX4aoKHjWudNQ2eeOtgscKvnasgLSFiRhg_Qju1aSIcf89D9Hw9ehreZncPN-Ph5V1muVIsg0FupOa5JBZKo6mqrJG20qSsrZCMCWkqzcuBLjWnNSiV61wYXgIheVkSzg_R-SZ3Hvx7B3FRzFy00DSmBd_FgimpJOV8QBM9-0Onvgttui4ppaUQSrOkLjbKBh9jgLqYBzczYVVQUnz1XKSei3XPyZ5-J3blDKpf-VNsAv0N-HANrP5PKm7HL5vIT05wg_0</recordid><startdate>202311</startdate><enddate>202311</enddate><creator>Ambrosioni, Juan</creator><creator>Levi, Laura</creator><creator>Alagaratnam, Jasmini</creator><creator>Van Bremen, Kathrin</creator><creator>Mastrangelo, Andrea</creator><creator>Waalewijn, Hylke</creator><creator>Molina, Jean‐Michel</creator><creator>Guaraldi, Giovanni</creator><creator>Winston, Alan</creator><creator>Boesecke, Christoph</creator><creator>Cinque, Paola</creator><creator>Bamford, Alasdair</creator><creator>Calmy, Alexandra</creator><creator>Marzolini, Catia</creator><creator>Martínez, Esteban</creator><creator>Oprea, Cristiana</creator><creator>Welch, Steven</creator><creator>Koval, Anna</creator><creator>Mendao, Luis</creator><creator>Rockstroh, Jürgen K.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5847-8416</orcidid><orcidid>https://orcid.org/0000-0003-2448-5957</orcidid><orcidid>https://orcid.org/0000-0002-5135-8729</orcidid><orcidid>https://orcid.org/0000-0001-9931-6686</orcidid><orcidid>https://orcid.org/0000-0003-2256-423X</orcidid><orcidid>https://orcid.org/0000-0002-5724-3914</orcidid><orcidid>https://orcid.org/0000-0003-4764-229X</orcidid><orcidid>https://orcid.org/0000-0001-9581-2527</orcidid></search><sort><creationdate>202311</creationdate><title>Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023</title><author>Ambrosioni, Juan ; Levi, Laura ; Alagaratnam, Jasmini ; Van Bremen, Kathrin ; Mastrangelo, Andrea ; Waalewijn, Hylke ; Molina, Jean‐Michel ; Guaraldi, Giovanni ; Winston, Alan ; Boesecke, Christoph ; Cinque, Paola ; Bamford, Alasdair ; Calmy, Alexandra ; Marzolini, Catia ; Martínez, Esteban ; Oprea, Cristiana ; Welch, Steven ; Koval, Anna ; Mendao, Luis ; Rockstroh, Jürgen K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-e56a793670ceba918dca7cd90bfc472247ad93b59b931fe886964a3be006bb033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abacavir</topic><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - drug therapy</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>Algorithms</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Anti-Retroviral Agents - therapeutic use</topic><topic>Antibodies</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral therapy</topic><topic>Breast feeding</topic><topic>Cancer screening</topic><topic>Child</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>COVID-19</topic><topic>Diabetes mellitus</topic><topic>Disease transmission</topic><topic>Drug interaction</topic><topic>Drug interactions</topic><topic>EACS</topic><topic>Emtricitabine</topic><topic>European AIDS Clinical Society</topic><topic>Guidelines</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Hepatitis C - drug therapy</topic><topic>HIV</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - drug therapy</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Integrase</topic><topic>Lamivudine</topic><topic>Lamivudine - therapeutic use</topic><topic>major updates</topic><topic>Medical screening</topic><topic>Monkeypox</topic><topic>Mpox</topic><topic>Mpox (monkeypox)</topic><topic>Practice Guidelines as Topic</topic><topic>Sexual health</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Tenofovir</topic><topic>Tenofovir - therapeutic use</topic><topic>V12.0</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ambrosioni, Juan</creatorcontrib><creatorcontrib>Levi, Laura</creatorcontrib><creatorcontrib>Alagaratnam, Jasmini</creatorcontrib><creatorcontrib>Van Bremen, Kathrin</creatorcontrib><creatorcontrib>Mastrangelo, Andrea</creatorcontrib><creatorcontrib>Waalewijn, Hylke</creatorcontrib><creatorcontrib>Molina, Jean‐Michel</creatorcontrib><creatorcontrib>Guaraldi, Giovanni</creatorcontrib><creatorcontrib>Winston, Alan</creatorcontrib><creatorcontrib>Boesecke, Christoph</creatorcontrib><creatorcontrib>Cinque, Paola</creatorcontrib><creatorcontrib>Bamford, Alasdair</creatorcontrib><creatorcontrib>Calmy, Alexandra</creatorcontrib><creatorcontrib>Marzolini, Catia</creatorcontrib><creatorcontrib>Martínez, Esteban</creatorcontrib><creatorcontrib>Oprea, Cristiana</creatorcontrib><creatorcontrib>Welch, Steven</creatorcontrib><creatorcontrib>Koval, Anna</creatorcontrib><creatorcontrib>Mendao, Luis</creatorcontrib><creatorcontrib>Rockstroh, Jürgen K.</creatorcontrib><creatorcontrib>EACS Governing Board</creatorcontrib><creatorcontrib>The EACS Governing Board</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>HIV medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambrosioni, Juan</au><au>Levi, Laura</au><au>Alagaratnam, Jasmini</au><au>Van Bremen, Kathrin</au><au>Mastrangelo, Andrea</au><au>Waalewijn, Hylke</au><au>Molina, Jean‐Michel</au><au>Guaraldi, Giovanni</au><au>Winston, Alan</au><au>Boesecke, Christoph</au><au>Cinque, Paola</au><au>Bamford, Alasdair</au><au>Calmy, Alexandra</au><au>Marzolini, Catia</au><au>Martínez, Esteban</au><au>Oprea, Cristiana</au><au>Welch, Steven</au><au>Koval, Anna</au><au>Mendao, Luis</au><au>Rockstroh, Jürgen K.</au><aucorp>EACS Governing Board</aucorp><aucorp>The EACS Governing Board</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023</atitle><jtitle>HIV medicine</jtitle><addtitle>HIV Med</addtitle><date>2023-11</date><risdate>2023</risdate><volume>24</volume><issue>11</issue><spage>1126</spage><epage>1136</epage><pages>1126-1136</pages><issn>1464-2662</issn><issn>1468-1293</issn><eissn>1468-1293</eissn><abstract>Background The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care were updated. Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first‐line treatment options for antiretroviral treatment (ART)‐naïve adults as versions 11.0 and 11.1: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long‐acting section has been expanded in the ART and drug–drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti‐infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient‐reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir‐free two‐drug regimens in people with isolated anti‐hepatitis B core antibodies are provided. In the opportunistic infections and COVID‐19 panel, guidance on the management of COVID‐19 in people with HIV has been updated according to the most up‐to‐date evidence, and a new section on monkeypox has been added. Conclusions In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37849432</pmid><doi>10.1111/hiv.13542</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5847-8416</orcidid><orcidid>https://orcid.org/0000-0003-2448-5957</orcidid><orcidid>https://orcid.org/0000-0002-5135-8729</orcidid><orcidid>https://orcid.org/0000-0001-9931-6686</orcidid><orcidid>https://orcid.org/0000-0003-2256-423X</orcidid><orcidid>https://orcid.org/0000-0002-5724-3914</orcidid><orcidid>https://orcid.org/0000-0003-4764-229X</orcidid><orcidid>https://orcid.org/0000-0001-9581-2527</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1464-2662
ispartof HIV medicine, 2023-11, Vol.24 (11), p.1126-1136
issn 1464-2662
1468-1293
1468-1293
language eng
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source Access via Wiley Online Library; MEDLINE
subjects Abacavir
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - drug therapy
Adolescent
Adolescents
Adult
AIDS
AIDS-Related Opportunistic Infections - drug therapy
Algorithms
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
Antibodies
Antiretroviral agents
Antiretroviral therapy
Breast feeding
Cancer screening
Child
Cognitive ability
Comorbidity
COVID-19
Diabetes mellitus
Disease transmission
Drug interaction
Drug interactions
EACS
Emtricitabine
European AIDS Clinical Society
Guidelines
Hepatitis
Hepatitis B
Hepatitis C
Hepatitis C - drug therapy
HIV
HIV Infections - diagnosis
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Infections
Integrase
Lamivudine
Lamivudine - therapeutic use
major updates
Medical screening
Monkeypox
Mpox
Mpox (monkeypox)
Practice Guidelines as Topic
Sexual health
Sexually transmitted diseases
STD
Tenofovir
Tenofovir - therapeutic use
V12.0
Vaccination
Vaccines
Viral diseases
Viruses
title Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023
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