Utility of palliative prognostic index and neutrophil‐to‐lymphocyte ratio in predicting prognosis of end‐stage squamous cell carcinoma of head and neck
Background The purpose of this study was to examine the factors influencing the prognosis of end‐stage head and neck squamous cell carcinoma (HNSCC) and to develop a more useful prognostic index. Patients and methods This retrospective observational study included 79 patients with end‐stage HNSCC. P...
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| Veröffentlicht in: | Head & neck 2024-01, Vol.46 (1), p.23-28 |
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| creator | Higashino, Masaaki Sugimoto, Kosuke Onishi, Shuji Okabe, Kohei Yasuda, Chika Tadokoro, Hiroshi Kawata, Ryo |
| description | Background
The purpose of this study was to examine the factors influencing the prognosis of end‐stage head and neck squamous cell carcinoma (HNSCC) and to develop a more useful prognostic index.
Patients and methods
This retrospective observational study included 79 patients with end‐stage HNSCC. Patients were grouped by patient factors and prognostic indicators, and overall survival from the start of Best Supportive Care was compared for each group. In addition, overall survival was compared between patients with palliative prognostic index (PPI) ≥6 and neutrophil‐to‐lymphocyte ratio (NLR) ≥10 and patients with PPI |
| doi_str_mv | 10.1002/hed.27549 |
| format | Article |
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The purpose of this study was to examine the factors influencing the prognosis of end‐stage head and neck squamous cell carcinoma (HNSCC) and to develop a more useful prognostic index.
Patients and methods
This retrospective observational study included 79 patients with end‐stage HNSCC. Patients were grouped by patient factors and prognostic indicators, and overall survival from the start of Best Supportive Care was compared for each group. In addition, overall survival was compared between patients with palliative prognostic index (PPI) ≥6 and neutrophil‐to‐lymphocyte ratio (NLR) ≥10 and patients with PPI <6 or NLR <10.
Results
PPI ≥6 and NLR ≥10 were associated with significantly more frequent poor prognoses (p = 0.01 and p = 0.002, respectively). The median survival was 32 days in cases with PPI ≥6 and NLR ≥10, and 64 days for PPI <6 or NLR <10 (p < 0.001).
Conclusion
The combination of PPI and NLR is a useful indicator for predicting the prognosis of patients with end‐stage HNSCC.</description><identifier>ISSN: 1043-3074</identifier><identifier>ISSN: 1097-0347</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27549</identifier><identifier>PMID: 37850401</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Carcinoma, Squamous Cell - pathology ; Head & neck cancer ; Head and neck carcinoma ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; head and neck squamous cell carcinoma ; Humans ; Leukocytes (neutrophilic) ; Lymphocyte Count ; Lymphocytes ; Lymphocytes - pathology ; Medical prognosis ; Neutrophils ; Neutrophils - pathology ; neutrophil‐lymphocyte ratio ; Palliation ; palliative ; palliative care ; Prognosis ; prognostic index ; Retrospective Studies ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - pathology ; Squamous Cell Carcinoma of Head and Neck - therapy</subject><ispartof>Head & neck, 2024-01, Vol.46 (1), p.23-28</ispartof><rights>2023 Wiley Periodicals LLC.</rights><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3139-21ddb442a50931b82ceef826bfc1ee151b3aec7aecfbcd4f345ff61467df1f293</cites><orcidid>0000-0003-2427-8122 ; 0000-0002-9905-5102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27549$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27549$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37850401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higashino, Masaaki</creatorcontrib><creatorcontrib>Sugimoto, Kosuke</creatorcontrib><creatorcontrib>Onishi, Shuji</creatorcontrib><creatorcontrib>Okabe, Kohei</creatorcontrib><creatorcontrib>Yasuda, Chika</creatorcontrib><creatorcontrib>Tadokoro, Hiroshi</creatorcontrib><creatorcontrib>Kawata, Ryo</creatorcontrib><title>Utility of palliative prognostic index and neutrophil‐to‐lymphocyte ratio in predicting prognosis of end‐stage squamous cell carcinoma of head and neck</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The purpose of this study was to examine the factors influencing the prognosis of end‐stage head and neck squamous cell carcinoma (HNSCC) and to develop a more useful prognostic index.
Patients and methods
This retrospective observational study included 79 patients with end‐stage HNSCC. Patients were grouped by patient factors and prognostic indicators, and overall survival from the start of Best Supportive Care was compared for each group. In addition, overall survival was compared between patients with palliative prognostic index (PPI) ≥6 and neutrophil‐to‐lymphocyte ratio (NLR) ≥10 and patients with PPI <6 or NLR <10.
Results
PPI ≥6 and NLR ≥10 were associated with significantly more frequent poor prognoses (p = 0.01 and p = 0.002, respectively). The median survival was 32 days in cases with PPI ≥6 and NLR ≥10, and 64 days for PPI <6 or NLR <10 (p < 0.001).
Conclusion
The combination of PPI and NLR is a useful indicator for predicting the prognosis of patients with end‐stage HNSCC.</description><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Head & neck cancer</subject><subject>Head and neck carcinoma</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>head and neck squamous cell carcinoma</subject><subject>Humans</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes - pathology</subject><subject>Medical prognosis</subject><subject>Neutrophils</subject><subject>Neutrophils - pathology</subject><subject>neutrophil‐lymphocyte ratio</subject><subject>Palliation</subject><subject>palliative</subject><subject>palliative care</subject><subject>Prognosis</subject><subject>prognostic index</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>Squamous Cell Carcinoma of Head and Neck - therapy</subject><issn>1043-3074</issn><issn>1097-0347</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1u1DAYhi0EoqWw4ALIEhtYpPVfxskSlUKRKrGh68ixP8-4OHFqO4XsOAIX4HKcBIeZ2SCx8I-s53v8Si9CLyk5p4Swix2YcyZr0T5Cp5S0siJcyMfrXfCKEylO0LOU7gghfCPYU3TCZVMTQegp-nWbnXd5wcHiSXnvVHYPgKcYtmNI2WnsRgPfsRoNHmHOMUw753__-JlD2fwyTLuglww4lsFQ4DIKxunsxu3R4tJqh9GUiZTVFnC6n9UQ5oQ1eI-1itqNYVArtgNlDr_pr8_RE6t8gheH8wzdfrj6cnld3Xz--Ony3U2lOeVtxagxvRBM1aTltG-YBrAN2_RWUwBa054r0LIs22sjLBe1tRsqNtJYalnLz9Cbvbckvp8h5W5wac2mRigxO9bIRlJKiSzo63_QuzDHsaTrWEuKk9eUF-rtntIxpBTBdlN0g4pLR0m3dtaVzrq_nRX21cE490N5PZLHkgpwsQe-OQ_L_03d9dX7vfIPDBGnSg</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Higashino, Masaaki</creator><creator>Sugimoto, Kosuke</creator><creator>Onishi, Shuji</creator><creator>Okabe, Kohei</creator><creator>Yasuda, Chika</creator><creator>Tadokoro, Hiroshi</creator><creator>Kawata, Ryo</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2427-8122</orcidid><orcidid>https://orcid.org/0000-0002-9905-5102</orcidid></search><sort><creationdate>202401</creationdate><title>Utility of palliative prognostic index and neutrophil‐to‐lymphocyte ratio in predicting prognosis of end‐stage squamous cell carcinoma of head and neck</title><author>Higashino, Masaaki ; Sugimoto, Kosuke ; Onishi, Shuji ; Okabe, Kohei ; Yasuda, Chika ; Tadokoro, Hiroshi ; Kawata, Ryo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3139-21ddb442a50931b82ceef826bfc1ee151b3aec7aecfbcd4f345ff61467df1f293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Head & neck cancer</topic><topic>Head and neck carcinoma</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>head and neck squamous cell carcinoma</topic><topic>Humans</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes - pathology</topic><topic>Medical prognosis</topic><topic>Neutrophils</topic><topic>Neutrophils - pathology</topic><topic>neutrophil‐lymphocyte ratio</topic><topic>Palliation</topic><topic>palliative</topic><topic>palliative care</topic><topic>Prognosis</topic><topic>prognostic index</topic><topic>Retrospective Studies</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>Squamous Cell Carcinoma of Head and Neck - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higashino, Masaaki</creatorcontrib><creatorcontrib>Sugimoto, Kosuke</creatorcontrib><creatorcontrib>Onishi, Shuji</creatorcontrib><creatorcontrib>Okabe, Kohei</creatorcontrib><creatorcontrib>Yasuda, Chika</creatorcontrib><creatorcontrib>Tadokoro, Hiroshi</creatorcontrib><creatorcontrib>Kawata, Ryo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higashino, Masaaki</au><au>Sugimoto, Kosuke</au><au>Onishi, Shuji</au><au>Okabe, Kohei</au><au>Yasuda, Chika</au><au>Tadokoro, Hiroshi</au><au>Kawata, Ryo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of palliative prognostic index and neutrophil‐to‐lymphocyte ratio in predicting prognosis of end‐stage squamous cell carcinoma of head and neck</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2024-01</date><risdate>2024</risdate><volume>46</volume><issue>1</issue><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>1043-3074</issn><issn>1097-0347</issn><eissn>1097-0347</eissn><abstract>Background
The purpose of this study was to examine the factors influencing the prognosis of end‐stage head and neck squamous cell carcinoma (HNSCC) and to develop a more useful prognostic index.
Patients and methods
This retrospective observational study included 79 patients with end‐stage HNSCC. Patients were grouped by patient factors and prognostic indicators, and overall survival from the start of Best Supportive Care was compared for each group. In addition, overall survival was compared between patients with palliative prognostic index (PPI) ≥6 and neutrophil‐to‐lymphocyte ratio (NLR) ≥10 and patients with PPI <6 or NLR <10.
Results
PPI ≥6 and NLR ≥10 were associated with significantly more frequent poor prognoses (p = 0.01 and p = 0.002, respectively). The median survival was 32 days in cases with PPI ≥6 and NLR ≥10, and 64 days for PPI <6 or NLR <10 (p < 0.001).
Conclusion
The combination of PPI and NLR is a useful indicator for predicting the prognosis of patients with end‐stage HNSCC.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>37850401</pmid><doi>10.1002/hed.27549</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2427-8122</orcidid><orcidid>https://orcid.org/0000-0002-9905-5102</orcidid></addata></record> |
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| subjects | Carcinoma, Squamous Cell - pathology Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy head and neck squamous cell carcinoma Humans Leukocytes (neutrophilic) Lymphocyte Count Lymphocytes Lymphocytes - pathology Medical prognosis Neutrophils Neutrophils - pathology neutrophil‐lymphocyte ratio Palliation palliative palliative care Prognosis prognostic index Retrospective Studies Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - therapy |
| title | Utility of palliative prognostic index and neutrophil‐to‐lymphocyte ratio in predicting prognosis of end‐stage squamous cell carcinoma of head and neck |
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