Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression

Smoking is an independent risk factor for atherosclerosis, the primary pathogenesis of which is inflammation. We recently reported that cigarette smoke extract (CSE) causes cytosolic and extracellular accumulation of both nuclear (n) and mitochondrial (mt) DNA, which leads to inflammation in human u...

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Veröffentlicht in:	Hypertension research 2024-01, Vol.47 (1), p.88-101
Hauptverfasser:	Kobayashi, Yusuke, Sakai, Chiemi, Ishida, Takafumi, Nagata, Minako, Nakano, Yukiko, Ishida, Mari
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - metabolism Acrolein - pharmacology Cigarette Smoking - adverse effects DNA, Mitochondrial - metabolism Endothelial Cells - metabolism Humans Inflammation - metabolism Interleukin-6 - metabolism Mitochondria - metabolism Tobacco Products
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