Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine

Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has been linked to depression pathology, changes in myelination may be a pivotal mechanism underlying ketamine’s long-lasting antidepressant effects. Although ketamine has a long-lasting facilitating effect on mye...

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Veröffentlicht in:	Molecular psychiatry 2024-06, Vol.29 (6), p.1741-1753
Hauptverfasser:	Huang, Chaoli, Wu, Zifeng, Wang, Di, Qu, Youge, Zhang, Jichun, Jiang, Riyue, Xu, Xiangqing, Xu, Xiangyang, Wang, Yuanyuan, Liu, Hanyu, He, Teng, Liu, Cunming, Chen, Guiquan, Yang, Jian-jun, Hashimoto, Kenji, Yang, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 38/47 631/378 692/699/476/1414 96/1 Animals Antidepressants Antidepressive Agents - pharmacology Behavioral Sciences Biological Psychology Cell differentiation Cell Differentiation - drug effects Depression - drug therapy Depression - metabolism Glial stem cells Hippocampus - drug effects Hippocampus - metabolism Ketamine Ketamine - pharmacology Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Myelin Basic Protein - metabolism Myelin Sheath - drug effects Myelin Sheath - metabolism Myelination Neurosciences Oligodendrocyte Precursor Cells - drug effects Oligodendrocyte Precursor Cells - metabolism Oligodendrocyte-myelin glycoprotein Oligodendrocytes Oligodendroglia - drug effects Oligodendroglia - metabolism Pharmacotherapy Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Psychiatry Social interactions Stereoisomers Stress, Psychological - drug therapy Stress, Psychological - metabolism Transcriptomics α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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