CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection

Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme. By performing a targeted loss‐of‐function screen in primary human fibroblasts, we...

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Veröffentlicht in:	EMBO reports 2023-12, Vol.24 (12), p.e56327-n/a
Hauptverfasser:	Burgess, Hannah M, Grande, Rebecca, Riccio, Sofia, Dinesh, Ikshitaa, Winkler, Gerlof Sebastiaan, Depledge, Daniel P, Mohr, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral activity CCR4‐NOT Cytomegalovirus deadenylation Decay Disruption DNA viruses Gene expression Gene sequencing Genomes HCMV Herpes viruses Herpesviridae Infections Hosts Humans Infections mRNA turnover Nuclease Polyadenine Receptors, CCR4 - genetics Receptors, CCR4 - metabolism Replication Ribonucleic acid RNA RNA decay RNA viruses RNA, Messenger - genetics RNA, Messenger - metabolism Therapeutic targets Transcription Factors - genetics Transcription Factors - metabolism Virology virus:host interaction
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