The prognostic contribution of CBL, NRAS, KRAS, RUNX1, and TP53 mutations to mutation‐enhanced international prognostic score systems (MIPSS70/plus/plus v2.0) for primary myelofibrosis

Contemporary risk models in primary myelofibrosis (PMF) include the mutation (MIPSS70) and mutation/karyotype enhanced (MIPSS70 plus/v2.0) international prognostic scoring systems. High molecular risk (HMR) mutations incorporated in one or both of these models include ASXL1, SRSF2, EZH2, IDH1/2, and...

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Veröffentlicht in:	American journal of hematology 2024-01, Vol.99 (1), p.68-78
Hauptverfasser:	Loscocco, Giuseppe G., Rotunno, Giada, Mannelli, Francesco, Coltro, Giacomo, Gesullo, Francesca, Pancani, Fabiana, Signori, Leonardo, Maccari, Chiara, Esposito, Maria, Paoli, Chiara, Vannucchi, Alessandro M., Guglielmelli, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Core Binding Factor Alpha 2 Subunit - genetics Female GTP Phosphohydrolases - genetics Hematology Humans Janus kinase 2 Karyotypes Leukemia Male Membrane Proteins - genetics Middle Aged Multivariate analysis Mutation Myelofibrosis p53 Protein Primary Myelofibrosis - diagnosis Primary Myelofibrosis - genetics Prognosis Proto-Oncogene Proteins p21(ras) - genetics Runx1 protein Statistical analysis Tumor Suppressor Protein p53 - genetics
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