Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)‐3‐(4‐(dimethylamino)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐one: An in vivo and in silico approach

Background Anxiety disorders represent the complex interaction between biological, psychological, temperamental, and environmental factors; drugs available to treat anxiety such as benzodiazepines (BZDs) are associated with several unwanted side effects. Although there are useful treatments, there i...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2024-04, Vol.38 (2), p.290-306
Hauptverfasser:	Santos Oliveira, Larissa, Kueirislene Amâncio Ferreira, Maria, Wagner de Queiroz Almeida‐Neto, Francisco, Wlisses da Silva, Antonio, Ivo Lima Pinto Filho, José, Nunes da Rocha, Matheus, Machado Marinho, Emanuelle, Henrique Ferreira Ribeiro, Walber, Machado Marinho, Márcia, Silva Marinho, Emmanuel, Eire Silva Alencar de Menezes, Jane, Santos, Hélcio Silva
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Antagonists Anxiety Anxiety disorders Anxiolytics Benzodiazepines Biocompatibility Central nervous system chalcone Chemical synthesis Danio rerio Environmental factors Freshwater fishes In vivo methods and tests Locomotion Locomotor activity Molecular docking Pharmacokinetics Pharmacology Psychotropic drugs Receptors Serotonin receptors Side effects Toxicity Toxicity testing Zebrafish γ-Aminobutyric acid A receptors
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