NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma

NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma

NOTCH1 and PIK3CA are members of important cell signalling pathways that are deregulated in squamous cell carcinomas of various organs. Vulvar squamous cell carcinomas (vulvSCC) are classically divided into two pathways, HPV-associated or HPV-independent, but the effect of NOTCH1 and PIK3CA mutation...

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Veröffentlicht in:Pathology, research and practice research and practice, 2023-11, Vol.251, p.154877-154877, Article 154877
Hauptverfasser: Choschzick, M., Stergiou, C., Gut, A., Zoche, M., Ross, JS, Moch, H.
Format: Artikel
Sprache:eng
Schlagworte:
Mutation
NOTCH1
PIK3CA
Vulvar cancer
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Zusammenfassung:NOTCH1 and PIK3CA are members of important cell signalling pathways that are deregulated in squamous cell carcinomas of various organs. Vulvar squamous cell carcinomas (vulvSCC) are classically divided into two pathways, HPV-associated or HPV-independent, but the effect of NOTCH1 and PIK3CA mutations in both groups is unclear. We analysed two different cohorts of vulvSCC using Hybrid Capture-based Comprehensive Genomic Profiling and identified NOTCH1 and PIK3CA mutations in 35% and 31% of 48 primary vulvSCC. In this first cohort, PIK3CA and NOTCH1 mutations were significantly correlated with HPV infection (p 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154877