Low anterior resection syndrome and its impact on quality of life of ovarian carcinoma patients: A prospective longitudinal study
Bowel dysfunction is frequently reported in patients with ovarian carcinoma (OC). Our aim was to evaluate the incidence of low anterior resection syndrome (LARS) like symptoms in patients with primary OC and its impact on quality of life (QoL). A prospective longitudinal observational cohort study w...
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| Veröffentlicht in: | Gynecologic oncology 2023-11, Vol.178, p.96-101 |
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| container_title | Gynecologic oncology |
| container_volume | 178 |
| creator | Imterat, Majdi Gebers, Gudrun Heitz, Florian Schneider, Stephanie Ehmann, Sarah Welz, Julia du Bois, Andreas Traut, Alexander Walz, Martin K Concin, Nicole Harter, Philipp Ataseven, Beyhan |
| description | Bowel dysfunction is frequently reported in patients with ovarian carcinoma (OC). Our aim was to evaluate the incidence of low anterior resection syndrome (LARS) like symptoms in patients with primary OC and its impact on quality of life (QoL).
A prospective longitudinal observational cohort study was performed, including patients with newly diagnosed OC treated by primary or interval surgery with residual tumor |
| doi_str_mv | 10.1016/j.ygyno.2023.10.002 |
| format | Article |
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A prospective longitudinal observational cohort study was performed, including patients with newly diagnosed OC treated by primary or interval surgery with residual tumor <1 cm, from 2018 until 2021. Patients with a stoma or recurrence of disease were excluded. Intestinal dysfunction was assessed using the validated LARS score questionnaire pre- and postoperatively. There are 3 subgroups based on the results: no, minor, or major LARS. The impact on QoL was evaluated by an additional question to demonstrate the severity of patient's life impairment.
The questionnaire was answered by 78 patients pre- and post-operatively. LARS like symptoms were reported preoperatively in 34.6% (24.4% minor/10.2% major) and significantly increased postoperatively to 47.4% (28.2% minor/19.2% major; p = 0.011). Moderate to severe impairment of QoL correlated with LARS scores pre- (80%) and post-operatively (90%). Patients with two bowel anastomoses (mean score 18.6 pre- and 24.9 post-operatively, p = 0.041) showed a significant increase of the questionnaire score.
Major LARS like symptoms appear in 10% of OC patients preoperatively and significantly increase to almost two-fold postoperatively. Multiple bowel anastomoses had a significant risk for higher postoperative LARS score. QoL impairment correlates linearly with LARS positive scoring, independent on the timing of the complaints.</description><identifier>ISSN: 0090-8258</identifier><identifier>ISSN: 1095-6859</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2023.10.002</identifier><identifier>PMID: 37839314</identifier><language>eng</language><publisher>United States</publisher><subject>Carcinoma, Ovarian Epithelial - surgery ; Female ; Humans ; Intestinal Diseases - etiology ; Longitudinal Studies ; Low Anterior Resection Syndrome ; Ovarian Neoplasms - complications ; Ovarian Neoplasms - surgery ; Postoperative Complications - etiology ; Prospective Studies ; Quality of Life ; Rectal Neoplasms - surgery</subject><ispartof>Gynecologic oncology, 2023-11, Vol.178, p.96-101</ispartof><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-b700e8c08397348704ec6cf779a321bbfcccdb9900b17b62dbeed420104e77003</citedby><cites>FETCH-LOGICAL-c305t-b700e8c08397348704ec6cf779a321bbfcccdb9900b17b62dbeed420104e77003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37839314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imterat, Majdi</creatorcontrib><creatorcontrib>Gebers, Gudrun</creatorcontrib><creatorcontrib>Heitz, Florian</creatorcontrib><creatorcontrib>Schneider, Stephanie</creatorcontrib><creatorcontrib>Ehmann, Sarah</creatorcontrib><creatorcontrib>Welz, Julia</creatorcontrib><creatorcontrib>du Bois, Andreas</creatorcontrib><creatorcontrib>Traut, Alexander</creatorcontrib><creatorcontrib>Walz, Martin K</creatorcontrib><creatorcontrib>Concin, Nicole</creatorcontrib><creatorcontrib>Harter, Philipp</creatorcontrib><creatorcontrib>Ataseven, Beyhan</creatorcontrib><title>Low anterior resection syndrome and its impact on quality of life of ovarian carcinoma patients: A prospective longitudinal study</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Bowel dysfunction is frequently reported in patients with ovarian carcinoma (OC). Our aim was to evaluate the incidence of low anterior resection syndrome (LARS) like symptoms in patients with primary OC and its impact on quality of life (QoL).
A prospective longitudinal observational cohort study was performed, including patients with newly diagnosed OC treated by primary or interval surgery with residual tumor <1 cm, from 2018 until 2021. Patients with a stoma or recurrence of disease were excluded. Intestinal dysfunction was assessed using the validated LARS score questionnaire pre- and postoperatively. There are 3 subgroups based on the results: no, minor, or major LARS. The impact on QoL was evaluated by an additional question to demonstrate the severity of patient's life impairment.
The questionnaire was answered by 78 patients pre- and post-operatively. LARS like symptoms were reported preoperatively in 34.6% (24.4% minor/10.2% major) and significantly increased postoperatively to 47.4% (28.2% minor/19.2% major; p = 0.011). Moderate to severe impairment of QoL correlated with LARS scores pre- (80%) and post-operatively (90%). Patients with two bowel anastomoses (mean score 18.6 pre- and 24.9 post-operatively, p = 0.041) showed a significant increase of the questionnaire score.
Major LARS like symptoms appear in 10% of OC patients preoperatively and significantly increase to almost two-fold postoperatively. Multiple bowel anastomoses had a significant risk for higher postoperative LARS score. QoL impairment correlates linearly with LARS positive scoring, independent on the timing of the complaints.</description><subject>Carcinoma, Ovarian Epithelial - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Diseases - etiology</subject><subject>Longitudinal Studies</subject><subject>Low Anterior Resection Syndrome</subject><subject>Ovarian Neoplasms - complications</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Postoperative Complications - etiology</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Rectal Neoplasms - surgery</subject><issn>0090-8258</issn><issn>1095-6859</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMouq7-AkFy9NJ1kuw2rTcRv2DBi55Lmk4lS5vUJFV69J-b-nWaYeZ9Z14eQs4YrBiw_HK3ml4n61YcuEiTFQDfIwsG5SbLi025TxYAJWQF3xRH5DiEHQAIYPyQHAlZiFKw9YJ8bt0HVTaiN85TjwF1NM7SMNnGux7TrqEmBmr6QelI0-ptVJ2JE3Ut7UyLc3XvyhtlqVZeG-t6RQcVDdoYrug1HbwLw3z3HWnn7KuJY2Os6mhIzXRCDlrVBTz9rUvycnf7fPOQbZ_uH2-ut5kWsIlZLQGw0JCCS7EuJKxR57qVslSCs7putdZNXZYANZN1zpsasVlzYEkok1csycXP3RTnbcQQq94EjV2nLLoxVLyQBXDIS5Gk4keqU_Lgsa0Gb3rlp4pBNbOvdtU3-2pmPw8T--Q6_30w1j02_54_2OILYB6EQw</recordid><startdate>202311</startdate><enddate>202311</enddate><creator>Imterat, Majdi</creator><creator>Gebers, Gudrun</creator><creator>Heitz, Florian</creator><creator>Schneider, Stephanie</creator><creator>Ehmann, Sarah</creator><creator>Welz, Julia</creator><creator>du Bois, Andreas</creator><creator>Traut, Alexander</creator><creator>Walz, Martin K</creator><creator>Concin, Nicole</creator><creator>Harter, Philipp</creator><creator>Ataseven, Beyhan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202311</creationdate><title>Low anterior resection syndrome and its impact on quality of life of ovarian carcinoma patients: A prospective longitudinal study</title><author>Imterat, Majdi ; Gebers, Gudrun ; Heitz, Florian ; Schneider, Stephanie ; Ehmann, Sarah ; Welz, Julia ; du Bois, Andreas ; Traut, Alexander ; Walz, Martin K ; Concin, Nicole ; Harter, Philipp ; Ataseven, Beyhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-b700e8c08397348704ec6cf779a321bbfcccdb9900b17b62dbeed420104e77003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma, Ovarian Epithelial - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Diseases - etiology</topic><topic>Longitudinal Studies</topic><topic>Low Anterior Resection Syndrome</topic><topic>Ovarian Neoplasms - complications</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Postoperative Complications - etiology</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Rectal Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imterat, Majdi</creatorcontrib><creatorcontrib>Gebers, Gudrun</creatorcontrib><creatorcontrib>Heitz, Florian</creatorcontrib><creatorcontrib>Schneider, Stephanie</creatorcontrib><creatorcontrib>Ehmann, Sarah</creatorcontrib><creatorcontrib>Welz, Julia</creatorcontrib><creatorcontrib>du Bois, Andreas</creatorcontrib><creatorcontrib>Traut, Alexander</creatorcontrib><creatorcontrib>Walz, Martin K</creatorcontrib><creatorcontrib>Concin, Nicole</creatorcontrib><creatorcontrib>Harter, Philipp</creatorcontrib><creatorcontrib>Ataseven, Beyhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imterat, Majdi</au><au>Gebers, Gudrun</au><au>Heitz, Florian</au><au>Schneider, Stephanie</au><au>Ehmann, Sarah</au><au>Welz, Julia</au><au>du Bois, Andreas</au><au>Traut, Alexander</au><au>Walz, Martin K</au><au>Concin, Nicole</au><au>Harter, Philipp</au><au>Ataseven, Beyhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low anterior resection syndrome and its impact on quality of life of ovarian carcinoma patients: A prospective longitudinal study</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2023-11</date><risdate>2023</risdate><volume>178</volume><spage>96</spage><epage>101</epage><pages>96-101</pages><issn>0090-8258</issn><issn>1095-6859</issn><eissn>1095-6859</eissn><abstract>Bowel dysfunction is frequently reported in patients with ovarian carcinoma (OC). Our aim was to evaluate the incidence of low anterior resection syndrome (LARS) like symptoms in patients with primary OC and its impact on quality of life (QoL).
A prospective longitudinal observational cohort study was performed, including patients with newly diagnosed OC treated by primary or interval surgery with residual tumor <1 cm, from 2018 until 2021. Patients with a stoma or recurrence of disease were excluded. Intestinal dysfunction was assessed using the validated LARS score questionnaire pre- and postoperatively. There are 3 subgroups based on the results: no, minor, or major LARS. The impact on QoL was evaluated by an additional question to demonstrate the severity of patient's life impairment.
The questionnaire was answered by 78 patients pre- and post-operatively. LARS like symptoms were reported preoperatively in 34.6% (24.4% minor/10.2% major) and significantly increased postoperatively to 47.4% (28.2% minor/19.2% major; p = 0.011). Moderate to severe impairment of QoL correlated with LARS scores pre- (80%) and post-operatively (90%). Patients with two bowel anastomoses (mean score 18.6 pre- and 24.9 post-operatively, p = 0.041) showed a significant increase of the questionnaire score.
Major LARS like symptoms appear in 10% of OC patients preoperatively and significantly increase to almost two-fold postoperatively. Multiple bowel anastomoses had a significant risk for higher postoperative LARS score. QoL impairment correlates linearly with LARS positive scoring, independent on the timing of the complaints.</abstract><cop>United States</cop><pmid>37839314</pmid><doi>10.1016/j.ygyno.2023.10.002</doi><tpages>6</tpages></addata></record> |
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| ispartof | Gynecologic oncology, 2023-11, Vol.178, p.96-101 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Carcinoma, Ovarian Epithelial - surgery Female Humans Intestinal Diseases - etiology Longitudinal Studies Low Anterior Resection Syndrome Ovarian Neoplasms - complications Ovarian Neoplasms - surgery Postoperative Complications - etiology Prospective Studies Quality of Life Rectal Neoplasms - surgery |
| title | Low anterior resection syndrome and its impact on quality of life of ovarian carcinoma patients: A prospective longitudinal study |
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