Targeted Delivery of Sucrose‐Coated Nanocarriers with Chemical Cargoes to the Plant Vasculature Enhances Long‐Distance Translocation
Current practices for delivering agrochemicals are inefficient, with only a fraction reaching the intended targets in plants. The surfaces of nanocarriers are functionalized with sucrose, enabling rapid and efficient foliar delivery into the plant phloem, a vascular tissue that transports sugars, si...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-02, Vol.20 (7), p.e2304588-n/a |
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| creator | Jeon, Su‐Ji Zhang, Yilin Castillo, Christopher Nava, Valeria Ristroph, Kurt Therrien, Benjamin Meza, Leticia Lowry, Gregory V. Giraldo, Juan Pablo |
| description | Current practices for delivering agrochemicals are inefficient, with only a fraction reaching the intended targets in plants. The surfaces of nanocarriers are functionalized with sucrose, enabling rapid and efficient foliar delivery into the plant phloem, a vascular tissue that transports sugars, signaling molecules, and agrochemicals through the whole plant. The chemical affinity of sucrose molecules to sugar membrane transporters on the phloem cells enhances the uptake of sucrose‐coated quantum dots (sucQD) and biocompatible carbon dots with β‐cyclodextrin molecular baskets (suc‐β‐CD) that can carry a wide range of agrochemicals. The QD and CD fluorescence emission properties allowed detection and monitoring of rapid translocation ( |
| doi_str_mv | 10.1002/smll.202304588 |
| format | Article |
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Nanocarriers coated in sucrose are guided with their chemical cargoes to the leaf vasculature via binding with sucrose transporters located in the phloem. The nanoparticles bypass leaf cell barriers and penetrate phloem cells through their membranes. Targeted sucrose‐coated nanoparticles enhance the delivery of chemical cargoes to the plant vasculature and their long‐distance translocation to roots.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.202304588</identifier><identifier>PMID: 37840413</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>active ingredients ; Agrochemicals ; Baskets ; Biocompatibility ; Biological Transport ; Cyclodextrins ; environmental nanotechnology ; Inductively coupled plasma ; Inductively coupled plasma mass spectrometry ; Mass spectrometry ; Membrane Transport Proteins - metabolism ; Nanoparticles ; nano‐enabled agriculture ; phloem ; Plant Leaves ; Plants - metabolism ; Quantum dots ; Roots ; Sucrose ; Sugar ; sugars ; Vascular tissue</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2024-02, Vol.20 (7), p.e2304588-n/a</ispartof><rights>2023 Wiley‐VCH GmbH</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3738-eff48cbf9c8fc5fb736cf554548dae72017b03d0d0ea366b94baa930aa5b36533</citedby><cites>FETCH-LOGICAL-c3738-eff48cbf9c8fc5fb736cf554548dae72017b03d0d0ea366b94baa930aa5b36533</cites><orcidid>0000-0002-5917-8837 ; 0000-0002-8400-8944</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsmll.202304588$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsmll.202304588$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37840413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Su‐Ji</creatorcontrib><creatorcontrib>Zhang, Yilin</creatorcontrib><creatorcontrib>Castillo, Christopher</creatorcontrib><creatorcontrib>Nava, Valeria</creatorcontrib><creatorcontrib>Ristroph, Kurt</creatorcontrib><creatorcontrib>Therrien, Benjamin</creatorcontrib><creatorcontrib>Meza, Leticia</creatorcontrib><creatorcontrib>Lowry, Gregory V.</creatorcontrib><creatorcontrib>Giraldo, Juan Pablo</creatorcontrib><title>Targeted Delivery of Sucrose‐Coated Nanocarriers with Chemical Cargoes to the Plant Vasculature Enhances Long‐Distance Translocation</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>Current practices for delivering agrochemicals are inefficient, with only a fraction reaching the intended targets in plants. The surfaces of nanocarriers are functionalized with sucrose, enabling rapid and efficient foliar delivery into the plant phloem, a vascular tissue that transports sugars, signaling molecules, and agrochemicals through the whole plant. The chemical affinity of sucrose molecules to sugar membrane transporters on the phloem cells enhances the uptake of sucrose‐coated quantum dots (sucQD) and biocompatible carbon dots with β‐cyclodextrin molecular baskets (suc‐β‐CD) that can carry a wide range of agrochemicals. The QD and CD fluorescence emission properties allowed detection and monitoring of rapid translocation (<40 min) in the vasculature of wheat leaves by confocal and epifluorescence microscopy. The suc‐β‐CDs more than doubled the delivery of chemical cargoes into the leaf vascular tissue. Inductively coupled plasma mass spectrometry (ICP‐MS) analysis showed that the fraction of sucQDs loaded into the phloem and transported to roots is over 6.8 times higher than unmodified QDs. The sucrose coating of nanoparticles approach enables unprecedented targeted delivery to roots with ≈70% of phloem‐loaded nanoparticles delivered to roots. The use of plant biorecognition molecules mediated delivery provides an efficient approach for guiding nanocarriers containing agrochemicals to the plant vasculature and whole plants.
Nanocarriers coated in sucrose are guided with their chemical cargoes to the leaf vasculature via binding with sucrose transporters located in the phloem. The nanoparticles bypass leaf cell barriers and penetrate phloem cells through their membranes. Targeted sucrose‐coated nanoparticles enhance the delivery of chemical cargoes to the plant vasculature and their long‐distance translocation to roots.</description><subject>active ingredients</subject><subject>Agrochemicals</subject><subject>Baskets</subject><subject>Biocompatibility</subject><subject>Biological Transport</subject><subject>Cyclodextrins</subject><subject>environmental nanotechnology</subject><subject>Inductively coupled plasma</subject><subject>Inductively coupled plasma mass spectrometry</subject><subject>Mass spectrometry</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Nanoparticles</subject><subject>nano‐enabled agriculture</subject><subject>phloem</subject><subject>Plant Leaves</subject><subject>Plants - metabolism</subject><subject>Quantum dots</subject><subject>Roots</subject><subject>Sucrose</subject><subject>Sugar</subject><subject>sugars</subject><subject>Vascular tissue</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT9v1DAYhyNERUthZUSWWFju8L_EzojSApVCQerBGjnO654rJy62Q3UbIyOfkU9SR1cOiYXptV4_fvSTf0XxguA1wZi-iaNza4opw7yU8lFxQirCVpWk9ePDmeDj4mmMNxgzQrl4UhwzITnmhJ0UPzcqXEOCAZ2Bs98h7JA36GrWwUf4_eNX49Vyeakmr1UIFkJEdzZtUbOF0WrlUJMFHiJKHqUtoM9OTQl9VVHPTqU5ADqftmrSmWj9dJ2VZzamZYE2QU3RZW-yfnpWHBnlIjx_mKfFl3fnm-bDqv30_qJ52640E0yuwBgudW9qLY0uTS9YpU1Z8pLLQYGgmIgeswEPGBSrqr7mvVI1w0qVPatKxk6L13vvbfDfZoipG23U4HJs8HPsqBQyS0TNM_rqH_TGz2HK6Tpa04qVglCSqfWeWr4sBjDdbbCjCruO4G7pqFs66g4d5QcvH7RzP8JwwP-UkoF6D9xZB7v_6Lqrj237V34PIaiiIw</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Jeon, Su‐Ji</creator><creator>Zhang, Yilin</creator><creator>Castillo, Christopher</creator><creator>Nava, Valeria</creator><creator>Ristroph, Kurt</creator><creator>Therrien, Benjamin</creator><creator>Meza, Leticia</creator><creator>Lowry, Gregory V.</creator><creator>Giraldo, Juan Pablo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5917-8837</orcidid><orcidid>https://orcid.org/0000-0002-8400-8944</orcidid></search><sort><creationdate>20240201</creationdate><title>Targeted Delivery of Sucrose‐Coated Nanocarriers with Chemical Cargoes to the Plant Vasculature Enhances Long‐Distance Translocation</title><author>Jeon, Su‐Ji ; Zhang, Yilin ; Castillo, Christopher ; Nava, Valeria ; Ristroph, Kurt ; Therrien, Benjamin ; Meza, Leticia ; Lowry, Gregory V. ; Giraldo, Juan Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3738-eff48cbf9c8fc5fb736cf554548dae72017b03d0d0ea366b94baa930aa5b36533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>active ingredients</topic><topic>Agrochemicals</topic><topic>Baskets</topic><topic>Biocompatibility</topic><topic>Biological Transport</topic><topic>Cyclodextrins</topic><topic>environmental nanotechnology</topic><topic>Inductively coupled plasma</topic><topic>Inductively coupled plasma mass spectrometry</topic><topic>Mass spectrometry</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Nanoparticles</topic><topic>nano‐enabled agriculture</topic><topic>phloem</topic><topic>Plant Leaves</topic><topic>Plants - metabolism</topic><topic>Quantum dots</topic><topic>Roots</topic><topic>Sucrose</topic><topic>Sugar</topic><topic>sugars</topic><topic>Vascular tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Su‐Ji</creatorcontrib><creatorcontrib>Zhang, Yilin</creatorcontrib><creatorcontrib>Castillo, Christopher</creatorcontrib><creatorcontrib>Nava, Valeria</creatorcontrib><creatorcontrib>Ristroph, Kurt</creatorcontrib><creatorcontrib>Therrien, Benjamin</creatorcontrib><creatorcontrib>Meza, Leticia</creatorcontrib><creatorcontrib>Lowry, Gregory V.</creatorcontrib><creatorcontrib>Giraldo, Juan Pablo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Su‐Ji</au><au>Zhang, Yilin</au><au>Castillo, Christopher</au><au>Nava, Valeria</au><au>Ristroph, Kurt</au><au>Therrien, Benjamin</au><au>Meza, Leticia</au><au>Lowry, Gregory V.</au><au>Giraldo, Juan Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted Delivery of Sucrose‐Coated Nanocarriers with Chemical Cargoes to the Plant Vasculature Enhances Long‐Distance Translocation</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>20</volume><issue>7</issue><spage>e2304588</spage><epage>n/a</epage><pages>e2304588-n/a</pages><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>Current practices for delivering agrochemicals are inefficient, with only a fraction reaching the intended targets in plants. The surfaces of nanocarriers are functionalized with sucrose, enabling rapid and efficient foliar delivery into the plant phloem, a vascular tissue that transports sugars, signaling molecules, and agrochemicals through the whole plant. The chemical affinity of sucrose molecules to sugar membrane transporters on the phloem cells enhances the uptake of sucrose‐coated quantum dots (sucQD) and biocompatible carbon dots with β‐cyclodextrin molecular baskets (suc‐β‐CD) that can carry a wide range of agrochemicals. The QD and CD fluorescence emission properties allowed detection and monitoring of rapid translocation (<40 min) in the vasculature of wheat leaves by confocal and epifluorescence microscopy. The suc‐β‐CDs more than doubled the delivery of chemical cargoes into the leaf vascular tissue. Inductively coupled plasma mass spectrometry (ICP‐MS) analysis showed that the fraction of sucQDs loaded into the phloem and transported to roots is over 6.8 times higher than unmodified QDs. The sucrose coating of nanoparticles approach enables unprecedented targeted delivery to roots with ≈70% of phloem‐loaded nanoparticles delivered to roots. The use of plant biorecognition molecules mediated delivery provides an efficient approach for guiding nanocarriers containing agrochemicals to the plant vasculature and whole plants.
Nanocarriers coated in sucrose are guided with their chemical cargoes to the leaf vasculature via binding with sucrose transporters located in the phloem. The nanoparticles bypass leaf cell barriers and penetrate phloem cells through their membranes. Targeted sucrose‐coated nanoparticles enhance the delivery of chemical cargoes to the plant vasculature and their long‐distance translocation to roots.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37840413</pmid><doi>10.1002/smll.202304588</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-5917-8837</orcidid><orcidid>https://orcid.org/0000-0002-8400-8944</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1613-6810 |
| ispartof | Small (Weinheim an der Bergstrasse, Germany), 2024-02, Vol.20 (7), p.e2304588-n/a |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | active ingredients Agrochemicals Baskets Biocompatibility Biological Transport Cyclodextrins environmental nanotechnology Inductively coupled plasma Inductively coupled plasma mass spectrometry Mass spectrometry Membrane Transport Proteins - metabolism Nanoparticles nano‐enabled agriculture phloem Plant Leaves Plants - metabolism Quantum dots Roots Sucrose Sugar sugars Vascular tissue |
| title | Targeted Delivery of Sucrose‐Coated Nanocarriers with Chemical Cargoes to the Plant Vasculature Enhances Long‐Distance Translocation |
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