Tumor cells‐derived exosomal noncoding RNAs in cancer angiogenesis: Molecular mechanisms and prospective

Exosomes, heterogeneous, membrane‐bound nanoparticles that originated from eukaryotic cells, contribute to intracellular communication by transferring various biomolecules both on their surface and as internal cargo. One of the most significant current discussions on cancer progression is noncoding RNAs cargo of exosomes, which can regulate angiogenesis in tumor. A growing body of evidence shows that exosomes from tumor cells contain various microRNAs, long noncoding RNAs, and circular RNAs that can promote tumor progression by inducing angiogenesis. However, some noncoding RNAs may inhibit cancer angiogenesis. Targeting angiogenic noncoding RNA of exosomes may serve as a hopeful implement for cancer therapy. In this review, we discuss the latest knowledge of the roles of exosomal noncoding RNAs in tumor angiogenesis Understanding the biology of exosomal noncoding RNAs can help scientists plan exosomes‐based innovations for the treatment of cancer angiogenesis and cancer biomarkers. Significance statement Angiogenesis is a key factor for cancer development. Exosomes from tumor cells carry various noncoding RNAs including microRNAs, long noncoding RNAs, and circular RNAs that promote tumor angiogenesis. Some exosomal noncoding RNAs may inhibit cancer angiogenesis. Targeting proangiogenic exosomal noncoding RNA may serve as a promising tool for cancer therapy.