Synthesis and evaluation of biodegradable segmented multiblock poly(ether ester) copolymers for biomaterial applications
Based on 1,4‐succinic acid, 1,4‐butanediol, poly(ethylene glycol)s and dimethyl terephthalate, biodegradable segmented multiblock copolymers of poly[(butylene terephthalate)‐co‐poly(butylene succinate)‐block‐poly(ethylene glycol)] (PTSG) were synthesized with different poly(butylene succinate) (PBS)...
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| Veröffentlicht in: | Polymer international 2004-12, Vol.53 (12), p.2145-2154 |
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| container_title | Polymer international |
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| creator | Wang, Lian-cai Chen, Jin-wu Liu, Hou-li Chen, Zhu-qiong Zhang, Yong Wang, Chang-yong Feng, Zeng-guo |
| description | Based on 1,4‐succinic acid, 1,4‐butanediol, poly(ethylene glycol)s and dimethyl terephthalate, biodegradable segmented multiblock copolymers of poly[(butylene terephthalate)‐co‐poly(butylene succinate)‐block‐poly(ethylene glycol)] (PTSG) were synthesized with different poly(butylene succinate) (PBS) molar fractions and varying the poly(ethylene glycol) (PEG) segment length, and were evaluated as biomedical materials. The copolymer extracts showed no in vitro cytotoxicity. However, sterilization of the copolymers by gamma irradiation had some limited effect on the cytotoxicity and mechanical properties. A copolymer consisting of PEG‐1000 and 20 mol% PBS, assigned as 1000PBS20 after SO2 gas plasma treatment, sustained the adhesion and growth of dog vascular smooth muscle cells. The in vivo biocompatibility of this sample was also measured subcutaneously in rats for 4 weeks. The assessments indicated that these poly(ether ester) copolymers are good candidates for anti‐adhesion barrier and drug controlled‐release applications. Copyright © 2004 Society of Chemical Industry |
| doi_str_mv | 10.1002/pi.1645 |
| format | Article |
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The copolymer extracts showed no in vitro cytotoxicity. However, sterilization of the copolymers by gamma irradiation had some limited effect on the cytotoxicity and mechanical properties. A copolymer consisting of PEG‐1000 and 20 mol% PBS, assigned as 1000PBS20 after SO2 gas plasma treatment, sustained the adhesion and growth of dog vascular smooth muscle cells. The in vivo biocompatibility of this sample was also measured subcutaneously in rats for 4 weeks. The assessments indicated that these poly(ether ester) copolymers are good candidates for anti‐adhesion barrier and drug controlled‐release applications. Copyright © 2004 Society of Chemical Industry</description><identifier>ISSN: 0959-8103</identifier><identifier>EISSN: 1097-0126</identifier><identifier>DOI: 10.1002/pi.1645</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Applied sciences ; biocompatibility ; Biological and medical sciences ; cell adhesion ; cytotoxicity ; degradation ; Exact sciences and technology ; Medical sciences ; Organic polymers ; Physicochemistry of polymers ; poly(ether ester) ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Technology. Biomaterials. Equipments. Material. Instrumentation</subject><ispartof>Polymer international, 2004-12, Vol.53 (12), p.2145-2154</ispartof><rights>2004 Society of Chemical Industry</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-7ae8ee1dfb7ed883a2c3db1db258defbdf4289032e50372c7e39da87137881383</citedby><cites>FETCH-LOGICAL-c3915-7ae8ee1dfb7ed883a2c3db1db258defbdf4289032e50372c7e39da87137881383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpi.1645$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpi.1645$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16262949$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lian-cai</creatorcontrib><creatorcontrib>Chen, Jin-wu</creatorcontrib><creatorcontrib>Liu, Hou-li</creatorcontrib><creatorcontrib>Chen, Zhu-qiong</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Wang, Chang-yong</creatorcontrib><creatorcontrib>Feng, Zeng-guo</creatorcontrib><title>Synthesis and evaluation of biodegradable segmented multiblock poly(ether ester) copolymers for biomaterial applications</title><title>Polymer international</title><addtitle>Polym. Int</addtitle><description>Based on 1,4‐succinic acid, 1,4‐butanediol, poly(ethylene glycol)s and dimethyl terephthalate, biodegradable segmented multiblock copolymers of poly[(butylene terephthalate)‐co‐poly(butylene succinate)‐block‐poly(ethylene glycol)] (PTSG) were synthesized with different poly(butylene succinate) (PBS) molar fractions and varying the poly(ethylene glycol) (PEG) segment length, and were evaluated as biomedical materials. The copolymer extracts showed no in vitro cytotoxicity. However, sterilization of the copolymers by gamma irradiation had some limited effect on the cytotoxicity and mechanical properties. A copolymer consisting of PEG‐1000 and 20 mol% PBS, assigned as 1000PBS20 after SO2 gas plasma treatment, sustained the adhesion and growth of dog vascular smooth muscle cells. The in vivo biocompatibility of this sample was also measured subcutaneously in rats for 4 weeks. The assessments indicated that these poly(ether ester) copolymers are good candidates for anti‐adhesion barrier and drug controlled‐release applications. Copyright © 2004 Society of Chemical Industry</description><subject>Applied sciences</subject><subject>biocompatibility</subject><subject>Biological and medical sciences</subject><subject>cell adhesion</subject><subject>cytotoxicity</subject><subject>degradation</subject><subject>Exact sciences and technology</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>poly(ether ester)</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Technology. Biomaterials. Equipments. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lian-cai</creatorcontrib><creatorcontrib>Chen, Jin-wu</creatorcontrib><creatorcontrib>Liu, Hou-li</creatorcontrib><creatorcontrib>Chen, Zhu-qiong</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Wang, Chang-yong</creatorcontrib><creatorcontrib>Feng, Zeng-guo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lian-cai</au><au>Chen, Jin-wu</au><au>Liu, Hou-li</au><au>Chen, Zhu-qiong</au><au>Zhang, Yong</au><au>Wang, Chang-yong</au><au>Feng, Zeng-guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and evaluation of biodegradable segmented multiblock poly(ether ester) copolymers for biomaterial applications</atitle><jtitle>Polymer international</jtitle><addtitle>Polym. Int</addtitle><date>2004-12</date><risdate>2004</risdate><volume>53</volume><issue>12</issue><spage>2145</spage><epage>2154</epage><pages>2145-2154</pages><issn>0959-8103</issn><eissn>1097-0126</eissn><abstract>Based on 1,4‐succinic acid, 1,4‐butanediol, poly(ethylene glycol)s and dimethyl terephthalate, biodegradable segmented multiblock copolymers of poly[(butylene terephthalate)‐co‐poly(butylene succinate)‐block‐poly(ethylene glycol)] (PTSG) were synthesized with different poly(butylene succinate) (PBS) molar fractions and varying the poly(ethylene glycol) (PEG) segment length, and were evaluated as biomedical materials. The copolymer extracts showed no in vitro cytotoxicity. However, sterilization of the copolymers by gamma irradiation had some limited effect on the cytotoxicity and mechanical properties. A copolymer consisting of PEG‐1000 and 20 mol% PBS, assigned as 1000PBS20 after SO2 gas plasma treatment, sustained the adhesion and growth of dog vascular smooth muscle cells. The in vivo biocompatibility of this sample was also measured subcutaneously in rats for 4 weeks. The assessments indicated that these poly(ether ester) copolymers are good candidates for anti‐adhesion barrier and drug controlled‐release applications. Copyright © 2004 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/pi.1645</doi><tpages>10</tpages></addata></record> |
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| subjects | Applied sciences biocompatibility Biological and medical sciences cell adhesion cytotoxicity degradation Exact sciences and technology Medical sciences Organic polymers Physicochemistry of polymers poly(ether ester) Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Synthesis and evaluation of biodegradable segmented multiblock poly(ether ester) copolymers for biomaterial applications |
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