Capsaicin indirectly regulates TRPA1 via the arachidonic acid cascade, resulting in TJ opening

ABSTRACT Capsaicin induces the reversible opening of tight junctions (TJs) and enhances the delivery of hydrophilic macromolecules through a paracellular route. We previously revealed that TRPA1 is involved in the capsaicin-induced Ca2+ influx and TJ permeability increase, although there are no repo...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2023-12, Vol.88 (1), p.44-52
Hauptverfasser:	Kanda, Yusuke, Mukaiyama, Minagi, Yamasaki, Yohei, Usui, Takeo, Nagumo, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acid - metabolism Arachidonic Acid - pharmacology Calcium - metabolism Capsaicin - pharmacology Cyclooxygenase 2 - genetics Phospholipases A2
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