Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain

The most conserved fusion loop (FL) domain present in the flavivirus envelope protein has been reported as a dominant epitope for cross-reactive antibodies to mosquito-borne flaviviruses (MBFVs). As a result, establishing accurate serodiagnosis for MBFV infections has been difficult as anti-FL antib...

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Veröffentlicht in:	Applied microbiology and biotechnology 2023-12, Vol.107 (24), p.7515-7529
Hauptverfasser:	Tabata, Koshiro, Itakura, Yukari, Ariizumi, Takuma, Igarashi, Manabu, Kobayashi, Hiroko, Intaruck, Kittiya, Kishimoto, Mai, Kobayashi, Shintaro, Hall, William W., Sasaki, Michihito, Sawa, Hirofumi, Orba, Yasuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Antibodies Antigen-antibody reactions Antigenicity Antigens Applied Genetics and Molecular Biotechnology Binding Biomedical and Life Sciences Biotechnology Cross-reactivity Dengue fever Encephalitis Env protein Enzyme-linked immunosorbent assay Epitopes Gene mutations Immunization Immunoassays Immunoglobulin G Inoculation Insects Life Sciences Microbial Genetics and Genomics Microbiology Mutants Mutation Vaccination Vaccines Vector-borne diseases Viral envelope proteins Viruses West Nile virus Zika virus
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