Inducing and monitoring mitochondrial pH changes with an iridium( iii ) complex via two-photon lifetime imaging
Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium( iii ) complex MitoIr-NH has been explored as a novel anticancer agent. Mit...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2023-11, Vol.52 (43), p.15859-15865 |
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| container_issue | 43 |
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| container_title | Dalton transactions : an international journal of inorganic chemistry |
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| creator | Hu, Meng Zhou, Xin-Lan Xiao, Tian-Xin Hao, Liang Li, Yi |
| description | Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium(
iii
) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner. |
| doi_str_mv | 10.1039/d3dt02541a |
| format | Article |
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iii
) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/d3dt02541a</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Iridium compounds ; Mitochondria ; Monitoring ; Phosphorescence ; Photons ; Real time</subject><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2023-11, Vol.52 (43), p.15859-15865</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c251t-a6230935f27f441d2465ec65ee397d353e8c1f1681aa00744b4f9191ecdbc8113</cites><orcidid>0000-0002-4543-684X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Hu, Meng</creatorcontrib><creatorcontrib>Zhou, Xin-Lan</creatorcontrib><creatorcontrib>Xiao, Tian-Xin</creatorcontrib><creatorcontrib>Hao, Liang</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><title>Inducing and monitoring mitochondrial pH changes with an iridium( iii ) complex via two-photon lifetime imaging</title><title>Dalton transactions : an international journal of inorganic chemistry</title><description>Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium(
iii
) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner.</description><subject>Anticancer properties</subject><subject>Iridium compounds</subject><subject>Mitochondria</subject><subject>Monitoring</subject><subject>Phosphorescence</subject><subject>Photons</subject><subject>Real time</subject><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLAzEUhYMoWKsbf0HATRVG85qZzLK0PgoFN3U9pEmmTZlJxiRj9d-bWnHh4nLPhY_DPQeAa4zuMaLVg6IqIpIzLE7ACLOyzCpC2emfJsU5uAhhhxAhKCcj4BZWDdLYDRRWwc5ZE50_nF0Scuus8ka0sH-BcivsRge4N3GbYGi8UWboJtAYA2-hdF3f6k_4YQSMe5f1Wxedha1pdDSdhqYTm-R7Cc4a0QZ99bvH4O3pcTV7yZavz4vZdJlJkuOYiYJQVNG8IWXDGFaEFbmWaTStSkVzqrnEDS44FgKhkrE1aypcYS3VWnKM6RhMjr69d--DDrHuTJC6bYXVbgg14WVJOcfogN78Q3du8DZ9lyhe5LTkmCXq7khJ70Lwuql7nzL5rxqj-tB9Pafz1U_3U_oND1p2Yw</recordid><startdate>20231107</startdate><enddate>20231107</enddate><creator>Hu, Meng</creator><creator>Zhou, Xin-Lan</creator><creator>Xiao, Tian-Xin</creator><creator>Hao, Liang</creator><creator>Li, Yi</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4543-684X</orcidid></search><sort><creationdate>20231107</creationdate><title>Inducing and monitoring mitochondrial pH changes with an iridium( iii ) complex via two-photon lifetime imaging</title><author>Hu, Meng ; Zhou, Xin-Lan ; Xiao, Tian-Xin ; Hao, Liang ; Li, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c251t-a6230935f27f441d2465ec65ee397d353e8c1f1681aa00744b4f9191ecdbc8113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticancer properties</topic><topic>Iridium compounds</topic><topic>Mitochondria</topic><topic>Monitoring</topic><topic>Phosphorescence</topic><topic>Photons</topic><topic>Real time</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Meng</creatorcontrib><creatorcontrib>Zhou, Xin-Lan</creatorcontrib><creatorcontrib>Xiao, Tian-Xin</creatorcontrib><creatorcontrib>Hao, Liang</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Meng</au><au>Zhou, Xin-Lan</au><au>Xiao, Tian-Xin</au><au>Hao, Liang</au><au>Li, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inducing and monitoring mitochondrial pH changes with an iridium( iii ) complex via two-photon lifetime imaging</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><date>2023-11-07</date><risdate>2023</risdate><volume>52</volume><issue>43</issue><spage>15859</spage><epage>15865</epage><pages>15859-15865</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium(
iii
) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d3dt02541a</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4543-684X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2023-11, Vol.52 (43), p.15859-15865 |
| issn | 1477-9226 1477-9234 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2877388101 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Anticancer properties Iridium compounds Mitochondria Monitoring Phosphorescence Photons Real time |
| title | Inducing and monitoring mitochondrial pH changes with an iridium( iii ) complex via two-photon lifetime imaging |
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