Berbamine targets cancer stem cells and reverses cabazitaxel resistance via inhibiting IGF2BP1 and p-STAT3 in prostate cancer

Cancer stem cells (CSCs) are a small subpopulation of tumor cells with the capability of self-renewal and drug resistance, leading to tumor progression and disease relapse. Our study aimed to investigate the antitumor effect of berbamine, extracted from berberis amurensis, on prostate CSCs. Sphere f...

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Veröffentlicht in:	The Prostate 2024-02, Vol.84 (2), p.131-147
Hauptverfasser:	Wang, Lili, Lyu, Chen, Stadlbauer, Birgit, Buchner, Alexander, Nößner, Elfriede, Pohla, Heike
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Apoptosis Cell Line, Tumor Cell Proliferation CXCR4 protein Drug resistance Exosomes Exosomes - metabolism Flow cytometry Humans Male MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Neoplasm Recurrence, Local - pathology Neoplastic Stem Cells - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Sequence analysis Stat3 protein STAT3 Transcription Factor - metabolism Stem cells Tumor cells Tumors
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