Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study
Patients with head and neck cancer (HNC) experience psychoneurological symptoms (PNS, i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity-modulated radiotherapy (IMRT) that negatively impact their functional status, quality of life, and overall survival. T...
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| Veröffentlicht in: | Journal of psychosomatic research 2023-12, Vol.175, p.111518-111518, Article 111518 |
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| container_title | Journal of psychosomatic research |
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| creator | Lin, Yufen Peng, Gang Bruner, Deborah W. Miller, Andrew H. Saba, Nabil F. Higgins, Kristin A. Shin, Dong M. Claussen, Henry Johnston, H. Richard Houser, Madelyn C. Wommack, Evanthia C. Xiao, Canhua |
| description | Patients with head and neck cancer (HNC) experience psychoneurological symptoms (PNS, i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity-modulated radiotherapy (IMRT) that negatively impact their functional status, quality of life, and overall survival. The underlying mechanisms for PNS are still not fully understood. This study aimed to examine differentially expressed genes and pathways related to PNS for patients undergoing IMRT (i.e., before, end of, 6 months, and 12 months after IMRT).
Participants included 142 patients with HNC (mean age 58.9 ± 10.3 years, 72.5% male, 83.1% White). Total RNA extracted from blood leukocytes were used for genome-wide gene expression assays. Linear mixed effects model was used to examine the association between PNS and gene expression across time. Gene Ontology (GO) enrichment analysis was employed to identify pathways related to PNS.
A total of 1352 genes (162 upregulated, 1190 downregulated) were significantly associated with PNS across time (false discovery rate (FDR) |
| doi_str_mv | 10.1016/j.jpsychores.2023.111518 |
| format | Article |
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Participants included 142 patients with HNC (mean age 58.9 ± 10.3 years, 72.5% male, 83.1% White). Total RNA extracted from blood leukocytes were used for genome-wide gene expression assays. Linear mixed effects model was used to examine the association between PNS and gene expression across time. Gene Ontology (GO) enrichment analysis was employed to identify pathways related to PNS.
A total of 1352 genes (162 upregulated, 1190 downregulated) were significantly associated with PNS across time (false discovery rate (FDR) < 0.05). Among these genes, 112 GO terms were identified (FDR < 0.05). The top 20 GO terms among the significant upregulated genes were related to immune and inflammatory responses, while the top 20 GO terms among the significant downregulated genes were associated with telomere maintenance.
This study is the first to identify genes and pathways linked to immune and inflammatory responses and telomere maintenance that are associated with PNS in patients with HNC receiving IMRT. Inflammation and aging markers may be candidate biomarkers for PNS. Understanding biological markers may produce targets for novel interventions.
•1352 genes (162 upregulated, 1190 downregulated) are identified•Two pathways are mainly involved: inflammatory responses and telomere maintenance•Inflammation and aging markers may be candidate biomarkers•Understanding biological markers may produce targets for novel interventions</description><identifier>ISSN: 0022-3999</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/j.jpsychores.2023.111518</identifier><identifier>PMID: 37832274</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Female ; Gene expression ; Head and neck cancer ; Head and Neck Neoplasms - genetics ; Humans ; Inflammation - genetics ; Longitudinal Studies ; Male ; Middle Aged ; Pathways ; Quality of Life ; Radiotherapy ; Radiotherapy, Intensity-Modulated ; Symptoms</subject><ispartof>Journal of psychosomatic research, 2023-12, Vol.175, p.111518-111518, Article 111518</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-1eaea8cdad4b47451420946a1e576a935e756d14fb7c2b24fdededc553e1be3f3</citedby><cites>FETCH-LOGICAL-c374t-1eaea8cdad4b47451420946a1e576a935e756d14fb7c2b24fdededc553e1be3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022399923003756$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37832274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yufen</creatorcontrib><creatorcontrib>Peng, Gang</creatorcontrib><creatorcontrib>Bruner, Deborah W.</creatorcontrib><creatorcontrib>Miller, Andrew H.</creatorcontrib><creatorcontrib>Saba, Nabil F.</creatorcontrib><creatorcontrib>Higgins, Kristin A.</creatorcontrib><creatorcontrib>Shin, Dong M.</creatorcontrib><creatorcontrib>Claussen, Henry</creatorcontrib><creatorcontrib>Johnston, H. Richard</creatorcontrib><creatorcontrib>Houser, Madelyn C.</creatorcontrib><creatorcontrib>Wommack, Evanthia C.</creatorcontrib><creatorcontrib>Xiao, Canhua</creatorcontrib><title>Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study</title><title>Journal of psychosomatic research</title><addtitle>J Psychosom Res</addtitle><description>Patients with head and neck cancer (HNC) experience psychoneurological symptoms (PNS, i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity-modulated radiotherapy (IMRT) that negatively impact their functional status, quality of life, and overall survival. The underlying mechanisms for PNS are still not fully understood. This study aimed to examine differentially expressed genes and pathways related to PNS for patients undergoing IMRT (i.e., before, end of, 6 months, and 12 months after IMRT).
Participants included 142 patients with HNC (mean age 58.9 ± 10.3 years, 72.5% male, 83.1% White). Total RNA extracted from blood leukocytes were used for genome-wide gene expression assays. Linear mixed effects model was used to examine the association between PNS and gene expression across time. Gene Ontology (GO) enrichment analysis was employed to identify pathways related to PNS.
A total of 1352 genes (162 upregulated, 1190 downregulated) were significantly associated with PNS across time (false discovery rate (FDR) < 0.05). Among these genes, 112 GO terms were identified (FDR < 0.05). The top 20 GO terms among the significant upregulated genes were related to immune and inflammatory responses, while the top 20 GO terms among the significant downregulated genes were associated with telomere maintenance.
This study is the first to identify genes and pathways linked to immune and inflammatory responses and telomere maintenance that are associated with PNS in patients with HNC receiving IMRT. Inflammation and aging markers may be candidate biomarkers for PNS. Understanding biological markers may produce targets for novel interventions.
•1352 genes (162 upregulated, 1190 downregulated) are identified•Two pathways are mainly involved: inflammatory responses and telomere maintenance•Inflammation and aging markers may be candidate biomarkers•Understanding biological markers may produce targets for novel interventions</description><subject>Aged</subject><subject>Female</subject><subject>Gene expression</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Humans</subject><subject>Inflammation - genetics</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathways</subject><subject>Quality of Life</subject><subject>Radiotherapy</subject><subject>Radiotherapy, Intensity-Modulated</subject><subject>Symptoms</subject><issn>0022-3999</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O1DAQhC0EYoeFV0A-csngnyROuA2r5UdaiQucLcfuzHhI7OBOgDwDL41HGeCI-uA-fFUldxFCOdtzxuvX5_15wtWeYgLcCybknnNe8eYR2fFGtQWXNXtMdowJUci2bW_IM8QzY6xuRfWU3EjVSCFUuSO_DojRejP7GJDGnjrf95AgzN4Mw0rh55QzEBw9QgCkP_x8olt2gCXFIR69NQPFdZzmOCL1gU7ZLRtc4RMYR01wNID9Sq0JFtIbeqBDDEc_L86Hizwv63PypDcDwovre0u-vLv_fPehePj0_uPd4aGwUpVzwcGAaawzruxKVVa8FKwta8OhUrVpZQWqqh0v-05Z0Ymyd5DHVpUE3oHs5S15tflOKX5bAGc9erQwDCZAXFCLRinZSMVZRpsNtSkiJuj1lPxo0qo505cq9Fn_q0JfqtBbFVn68pqydCO4v8I_t8_A2w2A_NfvHpJGm-9mwfkEdtYu-v-n_AYVEKSX</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Lin, Yufen</creator><creator>Peng, Gang</creator><creator>Bruner, Deborah W.</creator><creator>Miller, Andrew H.</creator><creator>Saba, Nabil F.</creator><creator>Higgins, Kristin A.</creator><creator>Shin, Dong M.</creator><creator>Claussen, Henry</creator><creator>Johnston, H. Richard</creator><creator>Houser, Madelyn C.</creator><creator>Wommack, Evanthia C.</creator><creator>Xiao, Canhua</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202312</creationdate><title>Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study</title><author>Lin, Yufen ; Peng, Gang ; Bruner, Deborah W. ; Miller, Andrew H. ; Saba, Nabil F. ; Higgins, Kristin A. ; Shin, Dong M. ; Claussen, Henry ; Johnston, H. Richard ; Houser, Madelyn C. ; Wommack, Evanthia C. ; Xiao, Canhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-1eaea8cdad4b47451420946a1e576a935e756d14fb7c2b24fdededc553e1be3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Female</topic><topic>Gene expression</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Humans</topic><topic>Inflammation - genetics</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathways</topic><topic>Quality of Life</topic><topic>Radiotherapy</topic><topic>Radiotherapy, Intensity-Modulated</topic><topic>Symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yufen</creatorcontrib><creatorcontrib>Peng, Gang</creatorcontrib><creatorcontrib>Bruner, Deborah W.</creatorcontrib><creatorcontrib>Miller, Andrew H.</creatorcontrib><creatorcontrib>Saba, Nabil F.</creatorcontrib><creatorcontrib>Higgins, Kristin A.</creatorcontrib><creatorcontrib>Shin, Dong M.</creatorcontrib><creatorcontrib>Claussen, Henry</creatorcontrib><creatorcontrib>Johnston, H. Richard</creatorcontrib><creatorcontrib>Houser, Madelyn C.</creatorcontrib><creatorcontrib>Wommack, Evanthia C.</creatorcontrib><creatorcontrib>Xiao, Canhua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychosomatic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yufen</au><au>Peng, Gang</au><au>Bruner, Deborah W.</au><au>Miller, Andrew H.</au><au>Saba, Nabil F.</au><au>Higgins, Kristin A.</au><au>Shin, Dong M.</au><au>Claussen, Henry</au><au>Johnston, H. Richard</au><au>Houser, Madelyn C.</au><au>Wommack, Evanthia C.</au><au>Xiao, Canhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study</atitle><jtitle>Journal of psychosomatic research</jtitle><addtitle>J Psychosom Res</addtitle><date>2023-12</date><risdate>2023</risdate><volume>175</volume><spage>111518</spage><epage>111518</epage><pages>111518-111518</pages><artnum>111518</artnum><issn>0022-3999</issn><eissn>1879-1360</eissn><abstract>Patients with head and neck cancer (HNC) experience psychoneurological symptoms (PNS, i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity-modulated radiotherapy (IMRT) that negatively impact their functional status, quality of life, and overall survival. The underlying mechanisms for PNS are still not fully understood. This study aimed to examine differentially expressed genes and pathways related to PNS for patients undergoing IMRT (i.e., before, end of, 6 months, and 12 months after IMRT).
Participants included 142 patients with HNC (mean age 58.9 ± 10.3 years, 72.5% male, 83.1% White). Total RNA extracted from blood leukocytes were used for genome-wide gene expression assays. Linear mixed effects model was used to examine the association between PNS and gene expression across time. Gene Ontology (GO) enrichment analysis was employed to identify pathways related to PNS.
A total of 1352 genes (162 upregulated, 1190 downregulated) were significantly associated with PNS across time (false discovery rate (FDR) < 0.05). Among these genes, 112 GO terms were identified (FDR < 0.05). The top 20 GO terms among the significant upregulated genes were related to immune and inflammatory responses, while the top 20 GO terms among the significant downregulated genes were associated with telomere maintenance.
This study is the first to identify genes and pathways linked to immune and inflammatory responses and telomere maintenance that are associated with PNS in patients with HNC receiving IMRT. Inflammation and aging markers may be candidate biomarkers for PNS. Understanding biological markers may produce targets for novel interventions.
•1352 genes (162 upregulated, 1190 downregulated) are identified•Two pathways are mainly involved: inflammatory responses and telomere maintenance•Inflammation and aging markers may be candidate biomarkers•Understanding biological markers may produce targets for novel interventions</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>37832274</pmid><doi>10.1016/j.jpsychores.2023.111518</doi><tpages>1</tpages></addata></record> |
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| ispartof | Journal of psychosomatic research, 2023-12, Vol.175, p.111518-111518, Article 111518 |
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| subjects | Aged Female Gene expression Head and neck cancer Head and Neck Neoplasms - genetics Humans Inflammation - genetics Longitudinal Studies Male Middle Aged Pathways Quality of Life Radiotherapy Radiotherapy, Intensity-Modulated Symptoms |
| title | Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study |
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