Effect of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: Insights from a multicenter retrospective cohort study
•The effects of soybean, medium-chain triacylglycerides, olive oil, and fish oil (SMOF) versus medium-chain triacylglycerides /long-chain triacylglycerides (MCT/LCT) on physical growth and extrauterine growth retardation in very preterm infants have not been reported.•Compared with MCT/LCT, SMOF can...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-12, Vol.116, p.112221, Article 112221 |
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| creator | Zhang, Zhu-Xin Yang, Qing Shen, Wei Song, Si-Yu Yang, Dong Song, Shi-Rong Zhang, Yi-Jia Xie, Jiang-Biao Tang, Li-Xia Kong, Juan Bai, Rui-Miao Yu, Wen-Ting Zhang, Juan Tong, Xiao-Mei Wu, Fan Li, Zhan-Kui Mao, Jian Lin, Xin-Zhu |
| description | •The effects of soybean, medium-chain triacylglycerides, olive oil, and fish oil (SMOF) versus medium-chain triacylglycerides /long-chain triacylglycerides (MCT/LCT) on physical growth and extrauterine growth retardation in very preterm infants have not been reported.•Compared with MCT/LCT, SMOF can reduce the risk for parenteral nutrition-associated cholestasis and metabolic bone disease of prematurity.•SMOF was an independent risk factor for lower weight growth velocity in very preterm infants but had no effect on the incidence of extrauterine growth retardation.
The aim of this study was to investigate the effects of soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, and extrauterine growth retardation (EUGR) in very preterm infants.
This was a multicenter retrospective cohort study of very preterm infants hospitalized in neonatal intensive care units at five tertiary hospitals in China between January 2021 and December 2021. According to the type of fat emulsion used in parenteral nutrition (PN), eligible very preterm infants were divided into the MCTs/long-chain triacylglycerol (MCT/LCT) group and SMOF group. Change in weight z-score (weight Δz) between measurements at birth and at 36 wk of postmenstrual age or at discharge, the incidence of EUGR, and short-term clinical outcomes between the two groups were compared and analyzed.
We enrolled 409 very preterm infants, including 205 in the MCT/LCT group and 204 in the SMOF group. Univariate analysis showed that infants in the SMOF group had significantly longer duration of invasive mechanical ventilation and PN, longer days to reach total enteral nutrition, and a higher proportion of maximum weight loss than those in MCT/LCT group (all P < 0.05). After adjusting for the confounding variables, multifactorial logistic regression analysis of short-term clinical outcomes showed that SMOF had protective effects on PN-associated cholestasis (odds ratio [OR], 0.470; 95% confidence interval [CI], 0.266–0.831) and metabolic bone disease of prematurity (OR, 0.263; 95% CI, 0.078–0.880). Additionally, SMOF was an independent risk factor for lower weight growth velocity (β = –0.733; 95% CI, –1.452 to –0.015) but had no effect on the incidence of EUGR (OR, 1.567; 95% CI, 0.912 to –2.693).
Compared with MCT/LCT, SMOF can reduce the risk for PN-associated cholestasis and metabolic bone disease of prematurity in very preterm infants and has a n |
| doi_str_mv | 10.1016/j.nut.2023.112221 |
| format | Article |
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The aim of this study was to investigate the effects of soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, and extrauterine growth retardation (EUGR) in very preterm infants.
This was a multicenter retrospective cohort study of very preterm infants hospitalized in neonatal intensive care units at five tertiary hospitals in China between January 2021 and December 2021. According to the type of fat emulsion used in parenteral nutrition (PN), eligible very preterm infants were divided into the MCTs/long-chain triacylglycerol (MCT/LCT) group and SMOF group. Change in weight z-score (weight Δz) between measurements at birth and at 36 wk of postmenstrual age or at discharge, the incidence of EUGR, and short-term clinical outcomes between the two groups were compared and analyzed.
We enrolled 409 very preterm infants, including 205 in the MCT/LCT group and 204 in the SMOF group. Univariate analysis showed that infants in the SMOF group had significantly longer duration of invasive mechanical ventilation and PN, longer days to reach total enteral nutrition, and a higher proportion of maximum weight loss than those in MCT/LCT group (all P < 0.05). After adjusting for the confounding variables, multifactorial logistic regression analysis of short-term clinical outcomes showed that SMOF had protective effects on PN-associated cholestasis (odds ratio [OR], 0.470; 95% confidence interval [CI], 0.266–0.831) and metabolic bone disease of prematurity (OR, 0.263; 95% CI, 0.078–0.880). Additionally, SMOF was an independent risk factor for lower weight growth velocity (β = –0.733; 95% CI, –1.452 to –0.015) but had no effect on the incidence of EUGR (OR, 1.567; 95% CI, 0.912 to –2.693).
Compared with MCT/LCT, SMOF can reduce the risk for PN-associated cholestasis and metabolic bone disease of prematurity in very preterm infants and has a negative effect on growth velocity but has no effect on the incidence of EUGR.</description><identifier>ISSN: 0899-9007</identifier><identifier>ISSN: 1873-1244</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2023.112221</identifier><identifier>PMID: 37832169</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Birth weight ; Bone diseases ; Bone Diseases, Metabolic ; Cholestasis ; Clinical outcomes ; Cohort analysis ; Confidence intervals ; Congenital diseases ; Disease ; Emulsions ; Enteral nutrition ; Extrauterine growth retardation ; Fat Emulsions, Intravenous - adverse effects ; Fatty acids ; Female ; Fetal Growth Retardation ; Fish Oils ; Gestational age ; Growth rate ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - epidemiology ; Infant, Premature, Diseases - prevention & control ; Infants ; Intensive care units ; Lipids ; Mechanical ventilation ; Metabolism ; Multiple oil-fat emulsions ; Neonates ; Newborn babies ; Nutrition ; Olive oil ; Parenteral nutrition ; Physical growth ; Premature babies ; Regression analysis ; Respiratory distress syndrome ; Retrospective Studies ; Risk factors ; Sepsis ; Soybean Oil ; Soybeans ; Standard scores ; Statistical analysis ; Traumatic brain injury ; Triglycerides ; Velocity ; Ventilators ; Very preterm infants ; Vitamin E ; Weight ; Weight loss</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2023-12, Vol.116, p.112221, Article 112221</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.</rights><rights>2023. The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-21e887cb654060fa93b21d6e2c717a119b8007959f3616ba5d126b25ee6a501c3</citedby><cites>FETCH-LOGICAL-c424t-21e887cb654060fa93b21d6e2c717a119b8007959f3616ba5d126b25ee6a501c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2889067337?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37832169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhu-Xin</creatorcontrib><creatorcontrib>Yang, Qing</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Song, Si-Yu</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Song, Shi-Rong</creatorcontrib><creatorcontrib>Zhang, Yi-Jia</creatorcontrib><creatorcontrib>Xie, Jiang-Biao</creatorcontrib><creatorcontrib>Tang, Li-Xia</creatorcontrib><creatorcontrib>Kong, Juan</creatorcontrib><creatorcontrib>Bai, Rui-Miao</creatorcontrib><creatorcontrib>Yu, Wen-Ting</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Tong, Xiao-Mei</creatorcontrib><creatorcontrib>Wu, Fan</creatorcontrib><creatorcontrib>Li, Zhan-Kui</creatorcontrib><creatorcontrib>Mao, Jian</creatorcontrib><creatorcontrib>Lin, Xin-Zhu</creatorcontrib><title>Effect of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: Insights from a multicenter retrospective cohort study</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>•The effects of soybean, medium-chain triacylglycerides, olive oil, and fish oil (SMOF) versus medium-chain triacylglycerides /long-chain triacylglycerides (MCT/LCT) on physical growth and extrauterine growth retardation in very preterm infants have not been reported.•Compared with MCT/LCT, SMOF can reduce the risk for parenteral nutrition-associated cholestasis and metabolic bone disease of prematurity.•SMOF was an independent risk factor for lower weight growth velocity in very preterm infants but had no effect on the incidence of extrauterine growth retardation.
The aim of this study was to investigate the effects of soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, and extrauterine growth retardation (EUGR) in very preterm infants.
This was a multicenter retrospective cohort study of very preterm infants hospitalized in neonatal intensive care units at five tertiary hospitals in China between January 2021 and December 2021. According to the type of fat emulsion used in parenteral nutrition (PN), eligible very preterm infants were divided into the MCTs/long-chain triacylglycerol (MCT/LCT) group and SMOF group. Change in weight z-score (weight Δz) between measurements at birth and at 36 wk of postmenstrual age or at discharge, the incidence of EUGR, and short-term clinical outcomes between the two groups were compared and analyzed.
We enrolled 409 very preterm infants, including 205 in the MCT/LCT group and 204 in the SMOF group. Univariate analysis showed that infants in the SMOF group had significantly longer duration of invasive mechanical ventilation and PN, longer days to reach total enteral nutrition, and a higher proportion of maximum weight loss than those in MCT/LCT group (all P < 0.05). After adjusting for the confounding variables, multifactorial logistic regression analysis of short-term clinical outcomes showed that SMOF had protective effects on PN-associated cholestasis (odds ratio [OR], 0.470; 95% confidence interval [CI], 0.266–0.831) and metabolic bone disease of prematurity (OR, 0.263; 95% CI, 0.078–0.880). Additionally, SMOF was an independent risk factor for lower weight growth velocity (β = –0.733; 95% CI, –1.452 to –0.015) but had no effect on the incidence of EUGR (OR, 1.567; 95% CI, 0.912 to –2.693).
Compared with MCT/LCT, SMOF can reduce the risk for PN-associated cholestasis and metabolic bone disease of prematurity in very preterm infants and has a negative effect on growth velocity but has no effect on the incidence of EUGR.</description><subject>Birth weight</subject><subject>Bone diseases</subject><subject>Bone Diseases, Metabolic</subject><subject>Cholestasis</subject><subject>Clinical outcomes</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Congenital diseases</subject><subject>Disease</subject><subject>Emulsions</subject><subject>Enteral nutrition</subject><subject>Extrauterine growth retardation</subject><subject>Fat Emulsions, Intravenous - adverse effects</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Fetal Growth Retardation</subject><subject>Fish Oils</subject><subject>Gestational age</subject><subject>Growth rate</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infant, Premature, Diseases - prevention & control</subject><subject>Infants</subject><subject>Intensive care units</subject><subject>Lipids</subject><subject>Mechanical ventilation</subject><subject>Metabolism</subject><subject>Multiple oil-fat emulsions</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Nutrition</subject><subject>Olive oil</subject><subject>Parenteral nutrition</subject><subject>Physical growth</subject><subject>Premature babies</subject><subject>Regression analysis</subject><subject>Respiratory distress syndrome</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Sepsis</subject><subject>Soybean Oil</subject><subject>Soybeans</subject><subject>Standard scores</subject><subject>Statistical analysis</subject><subject>Traumatic brain injury</subject><subject>Triglycerides</subject><subject>Velocity</subject><subject>Ventilators</subject><subject>Very preterm infants</subject><subject>Vitamin E</subject><subject>Weight</subject><subject>Weight 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of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: Insights from a multicenter retrospective cohort study</title><author>Zhang, Zhu-Xin ; Yang, Qing ; Shen, Wei ; Song, Si-Yu ; Yang, Dong ; Song, Shi-Rong ; Zhang, Yi-Jia ; Xie, Jiang-Biao ; Tang, Li-Xia ; Kong, Juan ; Bai, Rui-Miao ; Yu, Wen-Ting ; Zhang, Juan ; Tong, Xiao-Mei ; Wu, Fan ; Li, Zhan-Kui ; Mao, Jian ; Lin, Xin-Zhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-21e887cb654060fa93b21d6e2c717a119b8007959f3616ba5d126b25ee6a501c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Birth weight</topic><topic>Bone diseases</topic><topic>Bone Diseases, Metabolic</topic><topic>Cholestasis</topic><topic>Clinical outcomes</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Congenital 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Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhu-Xin</au><au>Yang, Qing</au><au>Shen, Wei</au><au>Song, Si-Yu</au><au>Yang, Dong</au><au>Song, Shi-Rong</au><au>Zhang, Yi-Jia</au><au>Xie, Jiang-Biao</au><au>Tang, Li-Xia</au><au>Kong, Juan</au><au>Bai, Rui-Miao</au><au>Yu, Wen-Ting</au><au>Zhang, Juan</au><au>Tong, Xiao-Mei</au><au>Wu, Fan</au><au>Li, Zhan-Kui</au><au>Mao, Jian</au><au>Lin, Xin-Zhu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: Insights from a multicenter retrospective cohort study</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2023-12</date><risdate>2023</risdate><volume>116</volume><spage>112221</spage><pages>112221-</pages><artnum>112221</artnum><issn>0899-9007</issn><issn>1873-1244</issn><eissn>1873-1244</eissn><abstract>•The effects of soybean, medium-chain triacylglycerides, olive oil, and fish oil (SMOF) versus medium-chain triacylglycerides /long-chain triacylglycerides (MCT/LCT) on physical growth and extrauterine growth retardation in very preterm infants have not been reported.•Compared with MCT/LCT, SMOF can reduce the risk for parenteral nutrition-associated cholestasis and metabolic bone disease of prematurity.•SMOF was an independent risk factor for lower weight growth velocity in very preterm infants but had no effect on the incidence of extrauterine growth retardation.
The aim of this study was to investigate the effects of soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, and extrauterine growth retardation (EUGR) in very preterm infants.
This was a multicenter retrospective cohort study of very preterm infants hospitalized in neonatal intensive care units at five tertiary hospitals in China between January 2021 and December 2021. According to the type of fat emulsion used in parenteral nutrition (PN), eligible very preterm infants were divided into the MCTs/long-chain triacylglycerol (MCT/LCT) group and SMOF group. Change in weight z-score (weight Δz) between measurements at birth and at 36 wk of postmenstrual age or at discharge, the incidence of EUGR, and short-term clinical outcomes between the two groups were compared and analyzed.
We enrolled 409 very preterm infants, including 205 in the MCT/LCT group and 204 in the SMOF group. Univariate analysis showed that infants in the SMOF group had significantly longer duration of invasive mechanical ventilation and PN, longer days to reach total enteral nutrition, and a higher proportion of maximum weight loss than those in MCT/LCT group (all P < 0.05). After adjusting for the confounding variables, multifactorial logistic regression analysis of short-term clinical outcomes showed that SMOF had protective effects on PN-associated cholestasis (odds ratio [OR], 0.470; 95% confidence interval [CI], 0.266–0.831) and metabolic bone disease of prematurity (OR, 0.263; 95% CI, 0.078–0.880). Additionally, SMOF was an independent risk factor for lower weight growth velocity (β = –0.733; 95% CI, –1.452 to –0.015) but had no effect on the incidence of EUGR (OR, 1.567; 95% CI, 0.912 to –2.693).
Compared with MCT/LCT, SMOF can reduce the risk for PN-associated cholestasis and metabolic bone disease of prematurity in very preterm infants and has a negative effect on growth velocity but has no effect on the incidence of EUGR.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37832169</pmid><doi>10.1016/j.nut.2023.112221</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2023-12, Vol.116, p.112221, Article 112221 |
| issn | 0899-9007 1873-1244 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2877383527 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Birth weight Bone diseases Bone Diseases, Metabolic Cholestasis Clinical outcomes Cohort analysis Confidence intervals Congenital diseases Disease Emulsions Enteral nutrition Extrauterine growth retardation Fat Emulsions, Intravenous - adverse effects Fatty acids Female Fetal Growth Retardation Fish Oils Gestational age Growth rate Hospitals Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - epidemiology Infant, Premature, Diseases - prevention & control Infants Intensive care units Lipids Mechanical ventilation Metabolism Multiple oil-fat emulsions Neonates Newborn babies Nutrition Olive oil Parenteral nutrition Physical growth Premature babies Regression analysis Respiratory distress syndrome Retrospective Studies Risk factors Sepsis Soybean Oil Soybeans Standard scores Statistical analysis Traumatic brain injury Triglycerides Velocity Ventilators Very preterm infants Vitamin E Weight Weight loss |
| title | Effect of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: Insights from a multicenter retrospective cohort study |
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