Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study
Identifying the predictors of acute kidney injury (AKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains important. We aimed to investigate the predictive value of d -dimer levels for the incidence of AKI i...
Gespeichert in:
| Veröffentlicht in: | Internal and emergency medicine 2024, Vol.19 (1), p.91-98 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 98 |
|---|---|
| container_issue | 1 |
| container_start_page | 91 |
| container_title | Internal and emergency medicine |
| container_volume | 19 |
| creator | Zhou, Xi Wang, Dingzhou Jin, Youkai Gong, Mengge Lin, Qingcheng He, Yanlei Huang, Weijian Shan, Peiren Liang, Dongjie |
| description | Identifying the predictors of acute kidney injury (AKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains important. We aimed to investigate the predictive value of
d
-dimer levels for the incidence of AKI in such a population, with particular attention paid to sex differences. A total of 2668 patients with STEMI who underwent PPCI were retrospectively included in this study and divided into quartiles according to their plasma
d
-dimer levels upon admission (Q1: 1.17 mg/L). The primary endpoint was the occurrence of AKI during hospitalization. AKI was observed in 503 (18.8%) patients. The mean age of the patients was 63.0 ± 13.2 years, 2155 (80.8%) of whom were men. Multivariate analysis indicated that higher
d
-dimer levels were associated with a significantly increased risk of AKI (Q4 vs. Q1: OR: 1.57; 95% CI 1.11–2.23;
P
= 0.011). However, the prognostic effect of
d
-dimer was only observed in male patients (Q4 vs. Q1: OR: 2.07; 95% CI 1.37–3.13;
P
|
| doi_str_mv | 10.1007/s11739-023-03443-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2877381261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2877381261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-7b5cd0b2c50246f1c8648a8acdc2ccfd8a23954efca12f92c3cc00166dd495983</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EouXCC7BAltiwCfgvscMOVfxJlVi0rCNnPG59uXEuttNyH5D3wrcpILFg47FmvnPG1iHkOWevOWP6TeZcy75hQjZMKlXPB-SU95o1vey6h_VuhGmYUvqEPMl5y1jbdlw_JidSG6mVMafk5wX-oC54jwkjYKYh0nKN1OY8Q7AlzJGOWG4RI3WNCxMmaqO7Y0KE4I4qOntqYSlIvwUX8VAn2yUdC91XC4wlU-umUAo6ehvKNb24bDJeTXVCcYc3657pMINNLthdVXqb4Nh9Sy1NWNKc91gbN3XZmDGtkkrmsrjDU_LI213GZ_d1Q75-eH959qk5__Lx89m78wak6EqjxxYcGwW0TKjOczCdMtZYcCAAvDNWyL5V6MFy4XsBEoAx3nXOqb7tjdyQV6vvPs3fF8xlmEIG3O1sxHnJgzBaS8NFxyv68h90Oy-pvrhSveBCcClVpcRKQf1gTuiHfQqTTYeBs-EY8rCGPNSQh7uQ67khL-6tl3FC90fyO9UKyBXIdRSvMP3d_R_bX8J6t3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2921221334</pqid></control><display><type>article</type><title>Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study</title><source>Springer Nature - Complete Springer Journals</source><creator>Zhou, Xi ; Wang, Dingzhou ; Jin, Youkai ; Gong, Mengge ; Lin, Qingcheng ; He, Yanlei ; Huang, Weijian ; Shan, Peiren ; Liang, Dongjie</creator><creatorcontrib>Zhou, Xi ; Wang, Dingzhou ; Jin, Youkai ; Gong, Mengge ; Lin, Qingcheng ; He, Yanlei ; Huang, Weijian ; Shan, Peiren ; Liang, Dongjie</creatorcontrib><description>Identifying the predictors of acute kidney injury (AKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains important. We aimed to investigate the predictive value of
d
-dimer levels for the incidence of AKI in such a population, with particular attention paid to sex differences. A total of 2668 patients with STEMI who underwent PPCI were retrospectively included in this study and divided into quartiles according to their plasma
d
-dimer levels upon admission (Q1: < 0.36; Q2: 0.36–0.67; Q3: 0.68–1.17; Q4: > 1.17 mg/L). The primary endpoint was the occurrence of AKI during hospitalization. AKI was observed in 503 (18.8%) patients. The mean age of the patients was 63.0 ± 13.2 years, 2155 (80.8%) of whom were men. Multivariate analysis indicated that higher
d
-dimer levels were associated with a significantly increased risk of AKI (Q4 vs. Q1: OR: 1.57; 95% CI 1.11–2.23;
P
= 0.011). However, the prognostic effect of
d
-dimer was only observed in male patients (Q4 vs. Q1: OR: 2.07; 95% CI 1.37–3.13;
P
< 0.001), not in female patients (Q4 vs. Q1: OR: 0.72; 95% CI 0.37–1.41;
P
= 0.342) (
P
for interaction = 0.003). We demonstrated a notable sex difference in the association between
d
-dimer level upon admission and AKI in a large STEMI patient sample. A higher
d
-dimer level was associated with an increased risk of AKI in male patients but not in female patients.</description><identifier>ISSN: 1828-0447</identifier><identifier>EISSN: 1970-9366</identifier><identifier>DOI: 10.1007/s11739-023-03443-0</identifier><identifier>PMID: 37837488</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Gender differences ; Gender Medicine ; Heart attacks ; Im - Original ; Internal Medicine ; Kidneys ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Myocardial infarction ; Sex differences</subject><ispartof>Internal and emergency medicine, 2024, Vol.19 (1), p.91-98</ispartof><rights>The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-7b5cd0b2c50246f1c8648a8acdc2ccfd8a23954efca12f92c3cc00166dd495983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11739-023-03443-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11739-023-03443-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37837488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Xi</creatorcontrib><creatorcontrib>Wang, Dingzhou</creatorcontrib><creatorcontrib>Jin, Youkai</creatorcontrib><creatorcontrib>Gong, Mengge</creatorcontrib><creatorcontrib>Lin, Qingcheng</creatorcontrib><creatorcontrib>He, Yanlei</creatorcontrib><creatorcontrib>Huang, Weijian</creatorcontrib><creatorcontrib>Shan, Peiren</creatorcontrib><creatorcontrib>Liang, Dongjie</creatorcontrib><title>Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study</title><title>Internal and emergency medicine</title><addtitle>Intern Emerg Med</addtitle><addtitle>Intern Emerg Med</addtitle><description>Identifying the predictors of acute kidney injury (AKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains important. We aimed to investigate the predictive value of
d
-dimer levels for the incidence of AKI in such a population, with particular attention paid to sex differences. A total of 2668 patients with STEMI who underwent PPCI were retrospectively included in this study and divided into quartiles according to their plasma
d
-dimer levels upon admission (Q1: < 0.36; Q2: 0.36–0.67; Q3: 0.68–1.17; Q4: > 1.17 mg/L). The primary endpoint was the occurrence of AKI during hospitalization. AKI was observed in 503 (18.8%) patients. The mean age of the patients was 63.0 ± 13.2 years, 2155 (80.8%) of whom were men. Multivariate analysis indicated that higher
d
-dimer levels were associated with a significantly increased risk of AKI (Q4 vs. Q1: OR: 1.57; 95% CI 1.11–2.23;
P
= 0.011). However, the prognostic effect of
d
-dimer was only observed in male patients (Q4 vs. Q1: OR: 2.07; 95% CI 1.37–3.13;
P
< 0.001), not in female patients (Q4 vs. Q1: OR: 0.72; 95% CI 0.37–1.41;
P
= 0.342) (
P
for interaction = 0.003). We demonstrated a notable sex difference in the association between
d
-dimer level upon admission and AKI in a large STEMI patient sample. A higher
d
-dimer level was associated with an increased risk of AKI in male patients but not in female patients.</description><subject>Gender differences</subject><subject>Gender Medicine</subject><subject>Heart attacks</subject><subject>Im - Original</subject><subject>Internal Medicine</subject><subject>Kidneys</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Myocardial infarction</subject><subject>Sex differences</subject><issn>1828-0447</issn><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1TAQhS0EouXCC7BAltiwCfgvscMOVfxJlVi0rCNnPG59uXEuttNyH5D3wrcpILFg47FmvnPG1iHkOWevOWP6TeZcy75hQjZMKlXPB-SU95o1vey6h_VuhGmYUvqEPMl5y1jbdlw_JidSG6mVMafk5wX-oC54jwkjYKYh0nKN1OY8Q7AlzJGOWG4RI3WNCxMmaqO7Y0KE4I4qOntqYSlIvwUX8VAn2yUdC91XC4wlU-umUAo6ehvKNb24bDJeTXVCcYc3657pMINNLthdVXqb4Nh9Sy1NWNKc91gbN3XZmDGtkkrmsrjDU_LI213GZ_d1Q75-eH959qk5__Lx89m78wak6EqjxxYcGwW0TKjOczCdMtZYcCAAvDNWyL5V6MFy4XsBEoAx3nXOqb7tjdyQV6vvPs3fF8xlmEIG3O1sxHnJgzBaS8NFxyv68h90Oy-pvrhSveBCcClVpcRKQf1gTuiHfQqTTYeBs-EY8rCGPNSQh7uQ67khL-6tl3FC90fyO9UKyBXIdRSvMP3d_R_bX8J6t3Q</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Zhou, Xi</creator><creator>Wang, Dingzhou</creator><creator>Jin, Youkai</creator><creator>Gong, Mengge</creator><creator>Lin, Qingcheng</creator><creator>He, Yanlei</creator><creator>Huang, Weijian</creator><creator>Shan, Peiren</creator><creator>Liang, Dongjie</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2024</creationdate><title>Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study</title><author>Zhou, Xi ; Wang, Dingzhou ; Jin, Youkai ; Gong, Mengge ; Lin, Qingcheng ; He, Yanlei ; Huang, Weijian ; Shan, Peiren ; Liang, Dongjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-7b5cd0b2c50246f1c8648a8acdc2ccfd8a23954efca12f92c3cc00166dd495983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Gender differences</topic><topic>Gender Medicine</topic><topic>Heart attacks</topic><topic>Im - Original</topic><topic>Internal Medicine</topic><topic>Kidneys</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Myocardial infarction</topic><topic>Sex differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Xi</creatorcontrib><creatorcontrib>Wang, Dingzhou</creatorcontrib><creatorcontrib>Jin, Youkai</creatorcontrib><creatorcontrib>Gong, Mengge</creatorcontrib><creatorcontrib>Lin, Qingcheng</creatorcontrib><creatorcontrib>He, Yanlei</creatorcontrib><creatorcontrib>Huang, Weijian</creatorcontrib><creatorcontrib>Shan, Peiren</creatorcontrib><creatorcontrib>Liang, Dongjie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Internal and emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xi</au><au>Wang, Dingzhou</au><au>Jin, Youkai</au><au>Gong, Mengge</au><au>Lin, Qingcheng</au><au>He, Yanlei</au><au>Huang, Weijian</au><au>Shan, Peiren</au><au>Liang, Dongjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study</atitle><jtitle>Internal and emergency medicine</jtitle><stitle>Intern Emerg Med</stitle><addtitle>Intern Emerg Med</addtitle><date>2024</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>91</spage><epage>98</epage><pages>91-98</pages><issn>1828-0447</issn><eissn>1970-9366</eissn><abstract>Identifying the predictors of acute kidney injury (AKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains important. We aimed to investigate the predictive value of
d
-dimer levels for the incidence of AKI in such a population, with particular attention paid to sex differences. A total of 2668 patients with STEMI who underwent PPCI were retrospectively included in this study and divided into quartiles according to their plasma
d
-dimer levels upon admission (Q1: < 0.36; Q2: 0.36–0.67; Q3: 0.68–1.17; Q4: > 1.17 mg/L). The primary endpoint was the occurrence of AKI during hospitalization. AKI was observed in 503 (18.8%) patients. The mean age of the patients was 63.0 ± 13.2 years, 2155 (80.8%) of whom were men. Multivariate analysis indicated that higher
d
-dimer levels were associated with a significantly increased risk of AKI (Q4 vs. Q1: OR: 1.57; 95% CI 1.11–2.23;
P
= 0.011). However, the prognostic effect of
d
-dimer was only observed in male patients (Q4 vs. Q1: OR: 2.07; 95% CI 1.37–3.13;
P
< 0.001), not in female patients (Q4 vs. Q1: OR: 0.72; 95% CI 0.37–1.41;
P
= 0.342) (
P
for interaction = 0.003). We demonstrated a notable sex difference in the association between
d
-dimer level upon admission and AKI in a large STEMI patient sample. A higher
d
-dimer level was associated with an increased risk of AKI in male patients but not in female patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37837488</pmid><doi>10.1007/s11739-023-03443-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1828-0447 |
| ispartof | Internal and emergency medicine, 2024, Vol.19 (1), p.91-98 |
| issn | 1828-0447 1970-9366 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2877381261 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Gender differences Gender Medicine Heart attacks Im - Original Internal Medicine Kidneys Medicine Medicine & Public Health Multivariate analysis Myocardial infarction Sex differences |
| title | Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T01%3A00%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20differences%20in%20the%20association%20between%20d-dimer%20and%20the%20incidence%20of%20acute%20kidney%20injury%20in%20patients%20admitted%20with%20ST-segment%20elevation%20myocardial%20infarction:%20a%20retrospective%20observational%20study&rft.jtitle=Internal%20and%20emergency%20medicine&rft.au=Zhou,%20Xi&rft.date=2024&rft.volume=19&rft.issue=1&rft.spage=91&rft.epage=98&rft.pages=91-98&rft.issn=1828-0447&rft.eissn=1970-9366&rft_id=info:doi/10.1007/s11739-023-03443-0&rft_dat=%3Cproquest_cross%3E2877381261%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2921221334&rft_id=info:pmid/37837488&rfr_iscdi=true |