Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy
Abstract Background With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant indi...
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creator | Kenmoe, Sebastien Chu, Helen Y Dawood, Fatimah S Milucky, Jennifer Kittikraisak, Wanitchaya Matthewson, Hamish Kulkarni, Durga Suntarattiwong, Piyarat Frivold, Collrane Mohanty, Sarita Havers, Fiona Li, You Nair, Harish |
description | Abstract
Background
With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant individuals the proportion of ARI testing positive for RSV and the RSV incidence rate, RSV-associated hospitalizations, deaths, and perinatal outcomes.
Methods
We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase, Global Health, Web of Science, and Global Index Medicus), and including additional unpublished data. Pregnant individuals with ARI who had respiratory samples tested for RSV were included. We used a random-effects meta-analysis to generate overall proportions and rate estimates across studies.
Results
Eleven studies with pregnant individuals recruited between 2010 and 2022 were identified, most of which recruited pregnant individuals in community, inpatient and outpatient settings. Among 8126 pregnant individuals, the proportion with ARI that tested positive for RSV ranged from 0.9% to 10.7%, with a meta-estimate of 3.4% (95% confidence interval [CI], 1.9%–54%). The pooled incidence rate of RSV among pregnant individuals was 26.0 (95% CI, 15.8–36.2) per 1000 person-years. RSV hospitalization rates reported in 2 studies were 2.4 and 3.0 per 1000 person-years. In 5 studies that ascertained RSV-associated deaths among 4708 pregnant individuals, no deaths were reported. Three studies comparing RSV-positive and RSV-negative pregnant individuals found no difference in the odds of miscarriage, stillbirth, low birth weight, and small size for gestational age. RSV-positive pregnant individuals had higher odds of preterm delivery (odds ratio, 3.6 [95% CI, 1.3–10.3]).
Conclusions
Data on RSV-associated hospitalization rates are limited, but available estimates are lower than those reported in older adults and young children. As countries debate whether to include RSV vaccines in maternal vaccination programs, which are primarily intended to protect infants, this information could be useful in shaping vaccine policy decisions. |
doi_str_mv | 10.1093/infdis/jiad449 |
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Background
With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant individuals the proportion of ARI testing positive for RSV and the RSV incidence rate, RSV-associated hospitalizations, deaths, and perinatal outcomes.
Methods
We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase, Global Health, Web of Science, and Global Index Medicus), and including additional unpublished data. Pregnant individuals with ARI who had respiratory samples tested for RSV were included. We used a random-effects meta-analysis to generate overall proportions and rate estimates across studies.
Results
Eleven studies with pregnant individuals recruited between 2010 and 2022 were identified, most of which recruited pregnant individuals in community, inpatient and outpatient settings. Among 8126 pregnant individuals, the proportion with ARI that tested positive for RSV ranged from 0.9% to 10.7%, with a meta-estimate of 3.4% (95% confidence interval [CI], 1.9%–54%). The pooled incidence rate of RSV among pregnant individuals was 26.0 (95% CI, 15.8–36.2) per 1000 person-years. RSV hospitalization rates reported in 2 studies were 2.4 and 3.0 per 1000 person-years. In 5 studies that ascertained RSV-associated deaths among 4708 pregnant individuals, no deaths were reported. Three studies comparing RSV-positive and RSV-negative pregnant individuals found no difference in the odds of miscarriage, stillbirth, low birth weight, and small size for gestational age. RSV-positive pregnant individuals had higher odds of preterm delivery (odds ratio, 3.6 [95% CI, 1.3–10.3]).
Conclusions
Data on RSV-associated hospitalization rates are limited, but available estimates are lower than those reported in older adults and young children. As countries debate whether to include RSV vaccines in maternal vaccination programs, which are primarily intended to protect infants, this information could be useful in shaping vaccine policy decisions.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiad449</identifier><identifier>PMID: 37824420</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Abortion, Spontaneous ; Aged ; Child ; Child, Preschool ; Databases, Factual ; Europe ; Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections - epidemiology</subject><ispartof>The Journal of infectious diseases, 2024-03, Vol.229 (Supplement_1), p.S51-S60</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-e43fd938431b2be94d9ada6ef6c8406ec830723057e25bfe84353a6ce8b8a1183</citedby><cites>FETCH-LOGICAL-c369t-e43fd938431b2be94d9ada6ef6c8406ec830723057e25bfe84353a6ce8b8a1183</cites><orcidid>0000-0002-8506-8439 ; 0000-0002-5536-080X ; 0000-0002-9432-9100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37824420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenmoe, Sebastien</creatorcontrib><creatorcontrib>Chu, Helen Y</creatorcontrib><creatorcontrib>Dawood, Fatimah S</creatorcontrib><creatorcontrib>Milucky, Jennifer</creatorcontrib><creatorcontrib>Kittikraisak, Wanitchaya</creatorcontrib><creatorcontrib>Matthewson, Hamish</creatorcontrib><creatorcontrib>Kulkarni, Durga</creatorcontrib><creatorcontrib>Suntarattiwong, Piyarat</creatorcontrib><creatorcontrib>Frivold, Collrane</creatorcontrib><creatorcontrib>Mohanty, Sarita</creatorcontrib><creatorcontrib>Havers, Fiona</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Nair, Harish</creatorcontrib><creatorcontrib>PROMISE Investigators</creatorcontrib><creatorcontrib>PROMISE Investigators</creatorcontrib><title>Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant individuals the proportion of ARI testing positive for RSV and the RSV incidence rate, RSV-associated hospitalizations, deaths, and perinatal outcomes.
Methods
We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase, Global Health, Web of Science, and Global Index Medicus), and including additional unpublished data. Pregnant individuals with ARI who had respiratory samples tested for RSV were included. We used a random-effects meta-analysis to generate overall proportions and rate estimates across studies.
Results
Eleven studies with pregnant individuals recruited between 2010 and 2022 were identified, most of which recruited pregnant individuals in community, inpatient and outpatient settings. Among 8126 pregnant individuals, the proportion with ARI that tested positive for RSV ranged from 0.9% to 10.7%, with a meta-estimate of 3.4% (95% confidence interval [CI], 1.9%–54%). The pooled incidence rate of RSV among pregnant individuals was 26.0 (95% CI, 15.8–36.2) per 1000 person-years. RSV hospitalization rates reported in 2 studies were 2.4 and 3.0 per 1000 person-years. In 5 studies that ascertained RSV-associated deaths among 4708 pregnant individuals, no deaths were reported. Three studies comparing RSV-positive and RSV-negative pregnant individuals found no difference in the odds of miscarriage, stillbirth, low birth weight, and small size for gestational age. RSV-positive pregnant individuals had higher odds of preterm delivery (odds ratio, 3.6 [95% CI, 1.3–10.3]).
Conclusions
Data on RSV-associated hospitalization rates are limited, but available estimates are lower than those reported in older adults and young children. As countries debate whether to include RSV vaccines in maternal vaccination programs, which are primarily intended to protect infants, this information could be useful in shaping vaccine policy decisions.</description><subject>Abortion, Spontaneous</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Databases, Factual</subject><subject>Europe</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Pregnancy</subject><subject>Respiratory Syncytial Virus, Human</subject><subject>Respiratory Tract Infections - epidemiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtOwzAUxnELgWgprIwoIwxpfUvijKVcpUogbmtw7OPKVZoEOxmy8Q68IU9CUAoSE9NZfucb_ggdEzwlOGUzWxpt_WxtpeY83UFjErEkjGPCdtEYY0pDItJ0hA68X2OMOYuTfTRiiaCcUzxGr-et01AGlQkewNfWyaZyXfDYlaprrCyCF-ta__n-Mfe-UlY2oIO5ahv4w29LA6qxVemDi9bZchXcO1iVsh85RHtGFh6OtneCnq8unxY34fLu-nYxX4aKxWkTAmdGp0xwRnKaQ8p1KrWMwcRKcByDEgwnlOEoARrlBnoYMRkrELmQhAg2QafDbu2qtxZ8k22sV1AUsoSq9RkVScIE5oL1dDpQ5SrvHZisdnYjXZcRnH1XzYaq2bZq_3Cy3W7zDehf_pOxB2cDqNr6v7EvFXyGKg</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Kenmoe, Sebastien</creator><creator>Chu, Helen Y</creator><creator>Dawood, Fatimah S</creator><creator>Milucky, Jennifer</creator><creator>Kittikraisak, Wanitchaya</creator><creator>Matthewson, Hamish</creator><creator>Kulkarni, Durga</creator><creator>Suntarattiwong, Piyarat</creator><creator>Frivold, Collrane</creator><creator>Mohanty, Sarita</creator><creator>Havers, Fiona</creator><creator>Li, You</creator><creator>Nair, Harish</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8506-8439</orcidid><orcidid>https://orcid.org/0000-0002-5536-080X</orcidid><orcidid>https://orcid.org/0000-0002-9432-9100</orcidid></search><sort><creationdate>20240301</creationdate><title>Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy</title><author>Kenmoe, Sebastien ; Chu, Helen Y ; Dawood, Fatimah S ; Milucky, Jennifer ; Kittikraisak, Wanitchaya ; Matthewson, Hamish ; Kulkarni, Durga ; Suntarattiwong, Piyarat ; Frivold, Collrane ; Mohanty, Sarita ; Havers, Fiona ; Li, You ; Nair, Harish</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-e43fd938431b2be94d9ada6ef6c8406ec830723057e25bfe84353a6ce8b8a1183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abortion, Spontaneous</topic><topic>Aged</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Databases, Factual</topic><topic>Europe</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Pregnancy</topic><topic>Respiratory Syncytial Virus, Human</topic><topic>Respiratory Tract Infections - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenmoe, Sebastien</creatorcontrib><creatorcontrib>Chu, Helen Y</creatorcontrib><creatorcontrib>Dawood, Fatimah S</creatorcontrib><creatorcontrib>Milucky, Jennifer</creatorcontrib><creatorcontrib>Kittikraisak, Wanitchaya</creatorcontrib><creatorcontrib>Matthewson, Hamish</creatorcontrib><creatorcontrib>Kulkarni, Durga</creatorcontrib><creatorcontrib>Suntarattiwong, Piyarat</creatorcontrib><creatorcontrib>Frivold, Collrane</creatorcontrib><creatorcontrib>Mohanty, Sarita</creatorcontrib><creatorcontrib>Havers, Fiona</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Nair, Harish</creatorcontrib><creatorcontrib>PROMISE Investigators</creatorcontrib><creatorcontrib>PROMISE Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kenmoe, Sebastien</au><au>Chu, Helen Y</au><au>Dawood, Fatimah S</au><au>Milucky, Jennifer</au><au>Kittikraisak, Wanitchaya</au><au>Matthewson, Hamish</au><au>Kulkarni, Durga</au><au>Suntarattiwong, Piyarat</au><au>Frivold, Collrane</au><au>Mohanty, Sarita</au><au>Havers, Fiona</au><au>Li, You</au><au>Nair, Harish</au><aucorp>PROMISE Investigators</aucorp><aucorp>PROMISE Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>229</volume><issue>Supplement_1</issue><spage>S51</spage><epage>S60</epage><pages>S51-S60</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant individuals the proportion of ARI testing positive for RSV and the RSV incidence rate, RSV-associated hospitalizations, deaths, and perinatal outcomes.
Methods
We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase, Global Health, Web of Science, and Global Index Medicus), and including additional unpublished data. Pregnant individuals with ARI who had respiratory samples tested for RSV were included. We used a random-effects meta-analysis to generate overall proportions and rate estimates across studies.
Results
Eleven studies with pregnant individuals recruited between 2010 and 2022 were identified, most of which recruited pregnant individuals in community, inpatient and outpatient settings. Among 8126 pregnant individuals, the proportion with ARI that tested positive for RSV ranged from 0.9% to 10.7%, with a meta-estimate of 3.4% (95% confidence interval [CI], 1.9%–54%). The pooled incidence rate of RSV among pregnant individuals was 26.0 (95% CI, 15.8–36.2) per 1000 person-years. RSV hospitalization rates reported in 2 studies were 2.4 and 3.0 per 1000 person-years. In 5 studies that ascertained RSV-associated deaths among 4708 pregnant individuals, no deaths were reported. Three studies comparing RSV-positive and RSV-negative pregnant individuals found no difference in the odds of miscarriage, stillbirth, low birth weight, and small size for gestational age. RSV-positive pregnant individuals had higher odds of preterm delivery (odds ratio, 3.6 [95% CI, 1.3–10.3]).
Conclusions
Data on RSV-associated hospitalization rates are limited, but available estimates are lower than those reported in older adults and young children. As countries debate whether to include RSV vaccines in maternal vaccination programs, which are primarily intended to protect infants, this information could be useful in shaping vaccine policy decisions.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>37824420</pmid><doi>10.1093/infdis/jiad449</doi><orcidid>https://orcid.org/0000-0002-8506-8439</orcidid><orcidid>https://orcid.org/0000-0002-5536-080X</orcidid><orcidid>https://orcid.org/0000-0002-9432-9100</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Abortion, Spontaneous Aged Child Child, Preschool Databases, Factual Europe Female Humans Infant Infant, Newborn Pregnancy Respiratory Syncytial Virus, Human Respiratory Tract Infections - epidemiology |
title | Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy |
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