Gender differences and clinical correlates in the age of the first hospitalization in patients with drug-naïve schizophrenia in China: a cross-sectional study
Gender differences in the onset age of schizophrenia have been reported in many studies, but differences in the age of the first hospitalization and associated factors have not been explored. The present study investigated gender differences and clinical correlates in the age of the first hospitaliz...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2024-09, Vol.274 (6), p.1417-1426 |
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| creator | Luo, Guoshuai Li, Meijuan Qiu, Yuying Yao, Cong Zhang, Xiangyang Li, Jie |
| description | Gender differences in the onset age of schizophrenia have been reported in many studies, but differences in the age of the first hospitalization and associated factors have not been explored. The present study investigated gender differences and clinical correlates in the age of the first hospitalization in drug-naïve schizophrenia (DNS). A total of 144 DNS patients and 67 health controls were included. Demographic information, duration of untreated psychosis (DUP), Positive and Negative Symptom Scale (PANSS) scores, the Brief Psychiatric Rating Scale (BPRS) scores, Global Assessment of Functioning (GAF) scores, and MATRICS Consensus Cognitive Battery (MCCB) scores were collected and analyzed. The age of the first hospitalization was significantly earlier in males than in females (P |
| doi_str_mv | 10.1007/s00406-023-01697-5 |
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Bonferroni
< 0.05/6 = 0.0083). Multivariate linear regression analysis showed that gender (β = 0.141, t = 2.434, P = 0.016), marital status (β = 0.219, t = 3.463, P = 0.001), family ranking (β = 0.300, t = 4.918, P < 0.001), suicide attempt (β = 0.348, t = 5.549, P < 0.001), and DUP (β = 0.190, t = 2.969, P < 0.004) positively predicted the age of the first hospitalization. The age of the first hospitalization in male DNS was earlier than in females. In addition, gender, marital status, suicide attempt, DUP, and family rank were independent risk factors for the age of the first hospitalization.]]></description><identifier>ISSN: 0940-1334</identifier><identifier>ISSN: 1433-8491</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-023-01697-5</identifier><identifier>PMID: 37833429</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Age ; Age of Onset ; China - epidemiology ; Cross-Sectional Studies ; Female ; Gender ; Gender differences ; Hospitalization ; Hospitalization - statistics & numerical data ; Humans ; Male ; Marital status ; Medicine ; Medicine & Public Health ; Mental disorders ; Middle Aged ; Neurosciences ; Original Paper ; Psychiatric Status Rating Scales ; Psychiatry ; Psychosis ; Risk factors ; Schizophrenia ; Schizophrenia - epidemiology ; Sex Characteristics ; Sex differences ; Sex Factors ; Suicide ; Suicides & suicide attempts ; Young Adult</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2024-09, Vol.274 (6), p.1417-1426</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-6f8505e1858b0b0ad4dac9f0f69f55b354c83b615f949126eac36cac681865503</cites><orcidid>0000-0001-5408-8413</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-023-01697-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-023-01697-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37833429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Guoshuai</creatorcontrib><creatorcontrib>Li, Meijuan</creatorcontrib><creatorcontrib>Qiu, Yuying</creatorcontrib><creatorcontrib>Yao, Cong</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><title>Gender differences and clinical correlates in the age of the first hospitalization in patients with drug-naïve schizophrenia in China: a cross-sectional study</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description><![CDATA[Gender differences in the onset age of schizophrenia have been reported in many studies, but differences in the age of the first hospitalization and associated factors have not been explored. The present study investigated gender differences and clinical correlates in the age of the first hospitalization in drug-naïve schizophrenia (DNS). A total of 144 DNS patients and 67 health controls were included. Demographic information, duration of untreated psychosis (DUP), Positive and Negative Symptom Scale (PANSS) scores, the Brief Psychiatric Rating Scale (BPRS) scores, Global Assessment of Functioning (GAF) scores, and MATRICS Consensus Cognitive Battery (MCCB) scores were collected and analyzed. The age of the first hospitalization was significantly earlier in males than in females (P < 0.01). In addition, there were significant differences in the age of the first hospitalization in terms of marital status, occupation, family ranking, suicide attempt, and place of residence (all P < 0.05). After Bonferroni correction, only DUP had a positive correlation with the age of the first hospitalization (P
Bonferroni
< 0.05/6 = 0.0083). Multivariate linear regression analysis showed that gender (β = 0.141, t = 2.434, P = 0.016), marital status (β = 0.219, t = 3.463, P = 0.001), family ranking (β = 0.300, t = 4.918, P < 0.001), suicide attempt (β = 0.348, t = 5.549, P < 0.001), and DUP (β = 0.190, t = 2.969, P < 0.004) positively predicted the age of the first hospitalization. The age of the first hospitalization in male DNS was earlier than in females. In addition, gender, marital status, suicide attempt, DUP, and family rank were independent risk factors for the age of the first hospitalization.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>China - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gender</subject><subject>Gender differences</subject><subject>Hospitalization</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Marital status</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Risk factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Suicide</subject><subject>Suicides & suicide attempts</subject><subject>Young Adult</subject><issn>0940-1334</issn><issn>1433-8491</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvhBTggS1x6MYzj2HG4oRUUpEpc4Bw5znjjKusstgNqX4ZH6EPwYji7BSQOnDwaf_P_Y_-EPOfwigM0rxNADYpBJRhw1TZMPiAbXgvBdN3yh2QDbQ2MC1GfkScpXQMAlxU8Jmei0aVbtRvy4xLDgJEO3jmMGCwmasJA7eSDt2aido4RJ5NL3weaR6Rmh3R2x9L5mDId53Tw2Uz-1mQ_h5U7lApDTvS7zyMd4rJjwfy8-4Y02dHfzoexeHmzotvRB_OGGmrjnBJLaFeR4pzyMtw8JY-cmRI-uz_PyZf37z5vP7CrT5cft2-vmBWVykw5LUEi11L30IMZ6sHY1oFTrZOyF7K2WvSKS9eWr6kUGiuUNVZprpWUIM7JxUn3EOevC6bc7X2yOE0m4LykrtJNI5pWK1XQl_-g1_MSy8apE9BqWTW1XgWrE3V8VkTXHaLfm3jTcejW-LpTfF2JrzvG18ky9OJeeun3OPwZ-Z1XAcQJSOUq7DD-9f6P7C-kJ6hH</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Luo, Guoshuai</creator><creator>Li, Meijuan</creator><creator>Qiu, Yuying</creator><creator>Yao, Cong</creator><creator>Zhang, Xiangyang</creator><creator>Li, Jie</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5408-8413</orcidid></search><sort><creationdate>202409</creationdate><title>Gender differences and clinical correlates in the age of the first hospitalization in patients with drug-naïve schizophrenia in China: a cross-sectional study</title><author>Luo, Guoshuai ; Li, Meijuan ; Qiu, Yuying ; Yao, Cong ; Zhang, Xiangyang ; Li, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-6f8505e1858b0b0ad4dac9f0f69f55b354c83b615f949126eac36cac681865503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>China - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gender</topic><topic>Gender differences</topic><topic>Hospitalization</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Marital status</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychosis</topic><topic>Risk factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Suicide</topic><topic>Suicides & suicide attempts</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Guoshuai</creatorcontrib><creatorcontrib>Li, Meijuan</creatorcontrib><creatorcontrib>Qiu, Yuying</creatorcontrib><creatorcontrib>Yao, Cong</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Guoshuai</au><au>Li, Meijuan</au><au>Qiu, Yuying</au><au>Yao, Cong</au><au>Zhang, Xiangyang</au><au>Li, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender differences and clinical correlates in the age of the first hospitalization in patients with drug-naïve schizophrenia in China: a cross-sectional study</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>2024-09</date><risdate>2024</risdate><volume>274</volume><issue>6</issue><spage>1417</spage><epage>1426</epage><pages>1417-1426</pages><issn>0940-1334</issn><issn>1433-8491</issn><eissn>1433-8491</eissn><abstract><![CDATA[Gender differences in the onset age of schizophrenia have been reported in many studies, but differences in the age of the first hospitalization and associated factors have not been explored. The present study investigated gender differences and clinical correlates in the age of the first hospitalization in drug-naïve schizophrenia (DNS). A total of 144 DNS patients and 67 health controls were included. Demographic information, duration of untreated psychosis (DUP), Positive and Negative Symptom Scale (PANSS) scores, the Brief Psychiatric Rating Scale (BPRS) scores, Global Assessment of Functioning (GAF) scores, and MATRICS Consensus Cognitive Battery (MCCB) scores were collected and analyzed. The age of the first hospitalization was significantly earlier in males than in females (P < 0.01). In addition, there were significant differences in the age of the first hospitalization in terms of marital status, occupation, family ranking, suicide attempt, and place of residence (all P < 0.05). After Bonferroni correction, only DUP had a positive correlation with the age of the first hospitalization (P
Bonferroni
< 0.05/6 = 0.0083). Multivariate linear regression analysis showed that gender (β = 0.141, t = 2.434, P = 0.016), marital status (β = 0.219, t = 3.463, P = 0.001), family ranking (β = 0.300, t = 4.918, P < 0.001), suicide attempt (β = 0.348, t = 5.549, P < 0.001), and DUP (β = 0.190, t = 2.969, P < 0.004) positively predicted the age of the first hospitalization. The age of the first hospitalization in male DNS was earlier than in females. In addition, gender, marital status, suicide attempt, DUP, and family rank were independent risk factors for the age of the first hospitalization.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37833429</pmid><doi>10.1007/s00406-023-01697-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5408-8413</orcidid></addata></record> |
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| subjects | Adolescent Adult Age Age of Onset China - epidemiology Cross-Sectional Studies Female Gender Gender differences Hospitalization Hospitalization - statistics & numerical data Humans Male Marital status Medicine Medicine & Public Health Mental disorders Middle Aged Neurosciences Original Paper Psychiatric Status Rating Scales Psychiatry Psychosis Risk factors Schizophrenia Schizophrenia - epidemiology Sex Characteristics Sex differences Sex Factors Suicide Suicides & suicide attempts Young Adult |
| title | Gender differences and clinical correlates in the age of the first hospitalization in patients with drug-naïve schizophrenia in China: a cross-sectional study |
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