Targeted single‐cell RNA sequencing analysis reveals metabolic reprogramming and the ferroptosis‐resistant state in hematologic malignancies

Hematologic malignancies are the most common hematopoietic diseases and a major public health concern. However, the mechanisms underlying myeloid tumors remain unknown owing to the intricate interplay between mutations and diverse clonal evolution patterns, as evidenced by the analysis of bulk cell‐...

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Veröffentlicht in:	Cell biochemistry and function 2023-12, Vol.41 (8), p.1343-1356
Hauptverfasser:	Shen, Xiaohui, Dong, Peiyuan, Kong, Jingjing, Sun, Nannan, Wang, Fang, Sang, Lina, Xu, Yan, Zhang, Mengmeng, Chen, Xiaoli, Guo, Rong, Wang, Shuya, Lin, Quande, Jiang, Zhongxing, Xu, Shan, Zhang, Congli, Bian, Zhilei, Wang, Weimin, Guo, Rongqun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Biological evolution Bone marrow Chemoresistance Chemotherapy Combinatorial analysis Customization Ferroptosis Gene sequencing Health services Hematologic Neoplasms - drug therapy Hematologic Neoplasms - genetics Heterogeneity Hierarchies Humans Leukemia Malignancy metabolic reprogramming Metabolism Microenvironments Mutation myelodysplastic syndromes oncogenic mutation Proto-Oncogene Proteins p21(ras) - genetics Public health Ribonucleic acid RNA Sequence analysis Sequence Analysis, RNA targeted single‐cell RNA sequencing Toxicity Transcriptomes Tumor Microenvironment Tumorigenesis
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