Radiosensitization by Hyperthermia Critically Depends on the Time Interval

Radiosensitization by Hyperthermia Critically Depends on the Time Interval

Hyperthermia is a potent sensitizer of radiation therapy that improves both tumor control and survival in women with locally advanced cervical cancer (LACC). The optimal sequence and interval between hyperthermia and radiation therapy are still under debate. We investigated the interval and sequence...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 2024-03, Vol.118 (3), p.817-828
Hauptverfasser: Mei, Xionge, Kok, H. Petra, Rodermond, Hans M., van Bochove, Gregor G.W., Snoek, Barbara C., van Leeuwen, Caspar M., Franken, Nicolaas A.P., ten Hagen, Timo L.M., Crezee, Johannes, Vermeulen, Louis, Stalpers, Lukas J.A., Oei, Arlene L.
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container_issue 3
container_start_page 817
container_title International journal of radiation oncology, biology, physics
container_volume 118
creator Mei, Xionge
Kok, H. Petra
Rodermond, Hans M.
van Bochove, Gregor G.W.
Snoek, Barbara C.
van Leeuwen, Caspar M.
Franken, Nicolaas A.P.
ten Hagen, Timo L.M.
Crezee, Johannes
Vermeulen, Louis
Stalpers, Lukas J.A.
Oei, Arlene L.
description Hyperthermia is a potent sensitizer of radiation therapy that improves both tumor control and survival in women with locally advanced cervical cancer (LACC). The optimal sequence and interval between hyperthermia and radiation therapy are still under debate. We investigated the interval and sequence in vitro in cervical cancer cell lines, patient-derived organoids, and SiHa cervical cancer hind leg xenografts in athymic nude mice and compared the results with retrospective results from 58 women with LACC treated with thermoradiotherapy. All 3 approaches confirmed that shortening the interval between hyperthermia and radiation therapy enhanced hyperthermic radiosensitization by 2 to 8 times more DNA double-strand breaks and apoptosis and 10 to 100 times lower cell survival, delayed tumor growth in mice, and increased the 5-year survival rate of women with LACC from 22% (interval ≥80 minutes) to 54% (interval
doi_str_mv 10.1016/j.ijrobp.2023.09.048
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