Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study
Purpose To determine the association between retinal blood vessel flow and geometric parameters and the risk of diabetic retinopathy (DR) progression through a 2-year prospective cohort study. Methods Patients with type 2 diabetes mellitus (T2DM) were recruited from a diabetic registry between Novem...
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| Veröffentlicht in: | Acta diabetologica 2024-02, Vol.61 (2), p.195-204 |
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| creator | Wu, Yi He, Mingguang Huang, Wenyong Wang, Wei |
| description | Purpose
To determine the association between retinal blood vessel flow and geometric parameters and the risk of diabetic retinopathy (DR) progression through a 2-year prospective cohort study.
Methods
Patients with type 2 diabetes mellitus (T2DM) were recruited from a diabetic registry between November 2017 and March 2019. All participants underwent standardized examinations at the baseline and 2-year follow-up visit, and the presence and severity of DR were assessed based on standard seven-field color fundus photographs. They also underwent swept-source optical coherence tomography angiography (OCTA) imaging to obtain measurements of foveal avascular zone area, blood vessel density (VD), fractal dimension (FD), blood vessel tortuosity (BVT) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP).
Results
A total of 233 eyes of 125 patients were included, and 40 eyes (17.17%) experienced DR progression within 2 years. DR progression was significantly associated with lower baseline VD (odds ratio [OR] 2.323 per SD decrease; 95% confidence interval [CI] 1.456–3.708;
P
|
| doi_str_mv | 10.1007/s00592-023-02194-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2876635634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2926602898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-11d3a0d30f53d6e52f2e60656d02e22924ad73c15fd71c43df5b3203192d27703</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EoqXwAiyQJTYsGrBnYjthV1X8SZXYwNryjScXV0l8sROu8ho8Maa5_IgFC8sjzXfOjH0YeyrFSymEeZWFUC1UArAc2dbV8R47lzVCpQDx_l_1GXuU860QEgw2D9kZmqbwRp2z71c5xy64OcQp8x3NR6KJJ5rD5AY-hi7Fby53y-AS74d4vOR7iiPNab3kbvL8kOI-Uc5FzmPPfXDFI3SbQzy4-cvKw8Tn9UAcTm3Kr7njUK1UTIc47cO8-Lt5uRTrY_agd0OmJ6f7gn1---bT9fvq5uO7D9dXN1WHRs2VlB6d8Ch6hV6Tgh5IC620F0AALdTOG-yk6r2RXY2-VzsEgbIFD8YIvGAvNt_yhq8L5dmOIXc0DG6iuGQLjdEalca6oM__QW_jksrGhWpBawFN2xQKNqp8Ws6JentIYXRptVLYn4nZLTFbErN3idljET07WS-7kfxvya-ICoAbkEtr2lP6M_s_tj8AVgqjEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2926602898</pqid></control><display><type>article</type><title>Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wu, Yi ; He, Mingguang ; Huang, Wenyong ; Wang, Wei</creator><creatorcontrib>Wu, Yi ; He, Mingguang ; Huang, Wenyong ; Wang, Wei</creatorcontrib><description>Purpose
To determine the association between retinal blood vessel flow and geometric parameters and the risk of diabetic retinopathy (DR) progression through a 2-year prospective cohort study.
Methods
Patients with type 2 diabetes mellitus (T2DM) were recruited from a diabetic registry between November 2017 and March 2019. All participants underwent standardized examinations at the baseline and 2-year follow-up visit, and the presence and severity of DR were assessed based on standard seven-field color fundus photographs. They also underwent swept-source optical coherence tomography angiography (OCTA) imaging to obtain measurements of foveal avascular zone area, blood vessel density (VD), fractal dimension (FD), blood vessel tortuosity (BVT) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP).
Results
A total of 233 eyes of 125 patients were included, and 40 eyes (17.17%) experienced DR progression within 2 years. DR progression was significantly associated with lower baseline VD (odds ratio [OR] 2.323 per SD decrease; 95% confidence interval [CI] 1.456–3.708;
P
< 0.001), lower FD (OR, 2.484 per SD decrease; 95% CI 1.268–4.867;
P
= 0.008), and higher BVT (OR, 2.076 per SD increase; 95% CI 1.382–3.121;
P
< 0.001) of the DCP after adjusting for confounding factors. The addition of OCTA metrics improved the predictive ability of the original model for DR progression (area under the curve [AUC] from 0.725 to 0.805;
P
= 0.022).
Conclusions
OCTA-derived VD, FD and BVT in the DCP were independent predictors of DR progression and showed additive value when added to established risk models predicting DR progression.</description><identifier>ISSN: 1432-5233</identifier><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-023-02194-w</identifier><identifier>PMID: 37819475</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Angiography ; Blood vessels ; Color vision ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetic retinopathy ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - etiology ; Fluorescein Angiography - methods ; Humans ; Internal Medicine ; Longitudinal Studies ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Microvasculature ; Original Article ; Prospective Studies ; Retina ; Retinal Vessels - diagnostic imaging ; Retinopathy ; Tomography, Optical Coherence - methods</subject><ispartof>Acta diabetologica, 2024-02, Vol.61 (2), p.195-204</ispartof><rights>Springer-Verlag Italia S.r.l., part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer-Verlag Italia S.r.l., part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-11d3a0d30f53d6e52f2e60656d02e22924ad73c15fd71c43df5b3203192d27703</citedby><cites>FETCH-LOGICAL-c375t-11d3a0d30f53d6e52f2e60656d02e22924ad73c15fd71c43df5b3203192d27703</cites><orcidid>0009-0000-0923-7248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-023-02194-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-023-02194-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37819475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yi</creatorcontrib><creatorcontrib>He, Mingguang</creatorcontrib><creatorcontrib>Huang, Wenyong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Purpose
To determine the association between retinal blood vessel flow and geometric parameters and the risk of diabetic retinopathy (DR) progression through a 2-year prospective cohort study.
Methods
Patients with type 2 diabetes mellitus (T2DM) were recruited from a diabetic registry between November 2017 and March 2019. All participants underwent standardized examinations at the baseline and 2-year follow-up visit, and the presence and severity of DR were assessed based on standard seven-field color fundus photographs. They also underwent swept-source optical coherence tomography angiography (OCTA) imaging to obtain measurements of foveal avascular zone area, blood vessel density (VD), fractal dimension (FD), blood vessel tortuosity (BVT) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP).
Results
A total of 233 eyes of 125 patients were included, and 40 eyes (17.17%) experienced DR progression within 2 years. DR progression was significantly associated with lower baseline VD (odds ratio [OR] 2.323 per SD decrease; 95% confidence interval [CI] 1.456–3.708;
P
< 0.001), lower FD (OR, 2.484 per SD decrease; 95% CI 1.268–4.867;
P
= 0.008), and higher BVT (OR, 2.076 per SD increase; 95% CI 1.382–3.121;
P
< 0.001) of the DCP after adjusting for confounding factors. The addition of OCTA metrics improved the predictive ability of the original model for DR progression (area under the curve [AUC] from 0.725 to 0.805;
P
= 0.022).
Conclusions
OCTA-derived VD, FD and BVT in the DCP were independent predictors of DR progression and showed additive value when added to established risk models predicting DR progression.</description><subject>Angiography</subject><subject>Blood vessels</subject><subject>Color vision</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - complications</subject><subject>Diabetic Retinopathy - etiology</subject><subject>Fluorescein Angiography - methods</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Longitudinal Studies</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Microvasculature</subject><subject>Original Article</subject><subject>Prospective Studies</subject><subject>Retina</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Retinopathy</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1432-5233</issn><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EoqXwAiyQJTYsGrBnYjthV1X8SZXYwNryjScXV0l8sROu8ho8Maa5_IgFC8sjzXfOjH0YeyrFSymEeZWFUC1UArAc2dbV8R47lzVCpQDx_l_1GXuU860QEgw2D9kZmqbwRp2z71c5xy64OcQp8x3NR6KJJ5rD5AY-hi7Fby53y-AS74d4vOR7iiPNab3kbvL8kOI-Uc5FzmPPfXDFI3SbQzy4-cvKw8Tn9UAcTm3Kr7njUK1UTIc47cO8-Lt5uRTrY_agd0OmJ6f7gn1---bT9fvq5uO7D9dXN1WHRs2VlB6d8Ch6hV6Tgh5IC620F0AALdTOG-yk6r2RXY2-VzsEgbIFD8YIvGAvNt_yhq8L5dmOIXc0DG6iuGQLjdEalca6oM__QW_jksrGhWpBawFN2xQKNqp8Ws6JentIYXRptVLYn4nZLTFbErN3idljET07WS-7kfxvya-ICoAbkEtr2lP6M_s_tj8AVgqjEA</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Wu, Yi</creator><creator>He, Mingguang</creator><creator>Huang, Wenyong</creator><creator>Wang, Wei</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0000-0923-7248</orcidid></search><sort><creationdate>20240201</creationdate><title>Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study</title><author>Wu, Yi ; He, Mingguang ; Huang, Wenyong ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-11d3a0d30f53d6e52f2e60656d02e22924ad73c15fd71c43df5b3203192d27703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angiography</topic><topic>Blood vessels</topic><topic>Color vision</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - complications</topic><topic>Diabetic Retinopathy - etiology</topic><topic>Fluorescein Angiography - methods</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Microvasculature</topic><topic>Original Article</topic><topic>Prospective Studies</topic><topic>Retina</topic><topic>Retinal Vessels - diagnostic imaging</topic><topic>Retinopathy</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yi</creatorcontrib><creatorcontrib>He, Mingguang</creatorcontrib><creatorcontrib>Huang, Wenyong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yi</au><au>He, Mingguang</au><au>Huang, Wenyong</au><au>Wang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>61</volume><issue>2</issue><spage>195</spage><epage>204</epage><pages>195-204</pages><issn>1432-5233</issn><issn>0940-5429</issn><eissn>1432-5233</eissn><abstract>Purpose
To determine the association between retinal blood vessel flow and geometric parameters and the risk of diabetic retinopathy (DR) progression through a 2-year prospective cohort study.
Methods
Patients with type 2 diabetes mellitus (T2DM) were recruited from a diabetic registry between November 2017 and March 2019. All participants underwent standardized examinations at the baseline and 2-year follow-up visit, and the presence and severity of DR were assessed based on standard seven-field color fundus photographs. They also underwent swept-source optical coherence tomography angiography (OCTA) imaging to obtain measurements of foveal avascular zone area, blood vessel density (VD), fractal dimension (FD), blood vessel tortuosity (BVT) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP).
Results
A total of 233 eyes of 125 patients were included, and 40 eyes (17.17%) experienced DR progression within 2 years. DR progression was significantly associated with lower baseline VD (odds ratio [OR] 2.323 per SD decrease; 95% confidence interval [CI] 1.456–3.708;
P
< 0.001), lower FD (OR, 2.484 per SD decrease; 95% CI 1.268–4.867;
P
= 0.008), and higher BVT (OR, 2.076 per SD increase; 95% CI 1.382–3.121;
P
< 0.001) of the DCP after adjusting for confounding factors. The addition of OCTA metrics improved the predictive ability of the original model for DR progression (area under the curve [AUC] from 0.725 to 0.805;
P
= 0.022).
Conclusions
OCTA-derived VD, FD and BVT in the DCP were independent predictors of DR progression and showed additive value when added to established risk models predicting DR progression.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>37819475</pmid><doi>10.1007/s00592-023-02194-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0009-0000-0923-7248</orcidid></addata></record> |
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| subjects | Angiography Blood vessels Color vision Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetic retinopathy Diabetic Retinopathy - complications Diabetic Retinopathy - etiology Fluorescein Angiography - methods Humans Internal Medicine Longitudinal Studies Medicine Medicine & Public Health Metabolic Diseases Microvasculature Original Article Prospective Studies Retina Retinal Vessels - diagnostic imaging Retinopathy Tomography, Optical Coherence - methods |
| title | Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study |
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